Abstract
Resistant metastatic cancer is at the moment an incurable disease and an unmet clinical need. It is one of the most lethal diseases and is causing thousands of deaths annually throughout the world. In this sense, nanomedicine-based drug delivery systems have brought a new hope for cancer patients in terms of reduced adverse effects and overcome resistance of the chemotherapeutical drugs. Even though the potential of nanomedicines, its clinical translation still suboptimal. A new focus and new paradigm of this prospective scientific field is thus urgently needed.
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Arnold, M., Rutherford, M.J., Bardot, A., Ferlay, J., Andersson, T.M.L., Myklebust, T.Ã., Tervonen, H., Thursfield, V., Ransom, D., Shack, L., Woods, R.R., Turner, D., Leonfellner, S., Ryan, S., Saint-Jacques, N., De, P., McClure, C., Ramanakumar, A.V., Stuart-Panko, H., Engholm, G., Walsh, P.M., Jackson, C., Vernon, S., Morgan, E., Gavin, A., Morrison, D.S., Huws, D.W., Porter, G., Butler, J., Bryant, H., Currow, D.C., Hiom, S., Parkin, D.M., Sasieni, P., Lambert, P.C., Møller, B., Soerjomataram, I., Bray, F.: Progress in cancer survival, mortality, and incidence in seven high-income countries 1995–2014 (ICBP SURVMARK-2): a population-based study. Lancet Oncol. 20(11), 1493–1505 (2011) 2019. https://doi.org/10.1016/S1470-2045(19)30456-5
Pilleron, S., AUID-ORCID: https:/., Sotoâ-Perezâ-deâ-Celis, E., Vignat, J., Ferlay, J., Soerjomataram, I., Bray, F.A., Sarfati, D.A.: Estimated global cancer incidence in the oldest adults in 2018 and projections to 2050. Int. J. Cancer 148(3), 601–608 (2003). 01 Feb 2021. Epub 17 Aug 2020. https://doi.org/10.1002/ijc.33232-8
Ulldemolins, A., Seras-Franzoso, J., Andrade, F., Rafael, D., Abasolo, I., Gener, P., Schwartz Jr, S.: Perspectives of nano-carrier drug delivery systems to overcome cancer drug resistance in the clinics. Cancer Drug Resist 3 (2020) (Online)
Xue, X.F., Liang, X.J.: Overcoming drug efflux-based multidrug resistance in cancer with nanotechnology. Chin. J. Cancer 31(2), 100–109 (2002). Feb 2012. https://doi.org/10.5732/cjc.0111.0326
Shi, J., Kantoff, P.W., Wooster, R., Farokhzad, O.C.: Cancer nanomedicine: progress, challenges and opportunities. Nat. Rev. Cancer 17(1), 20–37 (2001). Jan 2017. Epub 11 Nov 2016. https://doi.org/10.1038/nrc.2016.108
Salvioni, L., Rizzuto, M.A., Bertolini, J.A., Pandolfi, L., Colombo, M., Prosperi, D.A.: (Basel)—Thirty years of cancer nanomedicine: success, frustration, and hope. Cancers (Basel) 11(12) (2019). https://doi.org/10.3390/cancers11121855
van der Meel, R., Sulheim, E., Shi, Y., Kiessling, F., Mulder, W.J., Lammers, T.: Smart cancer nanomedicine: strategic directions to improve translation and exploitation. Nat. Nanotechnol. 14(11), 1007–1017 (2011). Nov 2019. Epub 06 Nov 2019. https://doi.org/10.1038/s41565-019-0567-y-17
Lee, G., Hall, R.R., III, Ahmed, A.U.: Cancer stem cells: cellular plasticity, niche, and its clinical relevance. J. Stem Cell Res. Ther. 6(10) (2010). Epub 2016 Oct 26–7633. https://doi.org/10.4172/2157-76331000363
Lengauer, C., Kinzler, K.W., Vogelstein, B.: Genetic instabilities in human cancers. Nature 396, 643–649 (1998)
Gener, P., Rafael, D.F., Fernandez, Y., Ortega, J.S., Arango, D., Abasolo, I., Videira, M., Schwartz, S., Jr.: Cancer stem cells and personalized cancer nanomedicine. Nanomedicine (Lond) 11, 307–320 (2016)
Shackleton, M., Quintana, E., Fearon, E.R., Morrison, S.J.: Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell 138, 822–829 (2009)
Hermann, P.C., Bhaskar, S., FAU., Cioffi, M., Cioffi, M.F., Heeschen, C. Cancer stem cells in solid tumors. Semin. Cancer Biol. 20(2), 77–84 (2002). Epub 3 Apr 2010. https://doi.org/10.1016/j.semcancer.2010.03.004
Sell, S.: Stem cell origin of cancer and differentiation therapy. Crit. Rev. Oncol. Hematol. 51(1), 1–28 (2001). Jul 2004. https://doi.org/10.1016/j.critrevonc.2004.04.007-28
Shackleton, M.: Normal stem cells and cancer stem cells: similar and different. Semin. Cancer Biol. 20, 85–92 (2010)
Olmeda, F., Ben, A.M.: Clonal pattern dynamics in tumor: the concept of cancer stem cells. Sci. Rep. 9(1), 15607 (2001). 30 Oct 2019. https://doi.org/10.1038/s41598-019-51575-1
Plaks, V., Kong, N., Werb, Z.: The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells? Cell Stem Cell 16(3), 225–38 (2003). 5 Mar 2015. https://doi.org/10.1016/j.stem.2015 02.015-38
Gener P, Gonzalez Callejo P, Seras-Franzoso J, Andrade F, Rafael D, Abasolo I, Schwartz S Jr. The potential of nanomedicine to alter cancer stem cell dynamics: the impact of extracellular vesicles. Nanomedicine (Lond). 2020 Dec;15(28):2785–2800. https://doi.org/10.2217/nnm-2020-0099. Epub 2020 Nov 16. PMID: 33191837
Gener, P., Seras-Franzoso, J., Gonzales Callego, P., Andrade, F., Rafael, D., et al.: Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer Cells. Stem Cells Int. (2018). (in press)
Shibue, T., Weinberg, R.A.: EMT, CSCs, and drug resistance: the mechanistic link and clinical implications. Nat. Rev. Clin. Oncol. 14(10):611–629 (2010). Oct 2017. Epub 11 Apr 2017. https://doi.org/10.1038/nrclinonc.2017.44
Wang, M., Zhao, J., Zhang, L., Wei, F., Lian, Y., Wu, Y., Gong, Z., Zhang, S., Zhou, J., Cao, K., Li, X., Xiong, W., Li, G., Zeng, Z., Guo, C.: Role of tumor microenvironment in tumorigenesis. J. Cancer 8(5), 761–773 (2005). 25 Feb 2017. https://doi.org/10.7150/jca.17648
Wicha, M.S., Liu, S., Dontu, G.: Cancer stem cells: an old idea–a paradigm shift. Cancer Res. 66, 1883–1890 (2006)
Gener, P., Rafael, D., Seras-Franzoso, J., Perez, A., Pindado, L.A., Casas, G., Arango, D., Fernandez, Y., Diaz-Riascos, Z.V., Abasolo, I., Schwartz, S Jr. (Basel).: Pivotal role of AKT2 during dynamic phenotypic change of breast cancer stem cells. Cancers (Basel) 11(8) 2019 Jul 26. https://doi.org/10.3390/cancers11081058
Gupta, P.B., Fillmore, C.M., Jiang, G., Shapira, S.D., Tao, K., Kuperwasser, C., Lander, E.S.: Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell 146, 633–644 (2011)
Cabrera, M.C., FAU., Hollingsworth, R., Hollingsworth, R.E., FAU., Hurt, E., Hurt, E.M.: Cancer stem cell plasticity and tumor hierarchy. World J. Stem Cells 7(1), 27–36 (2001). Epub 26 Jan 2015. https://doi.org/10.4252/wjsc.v7.i1.27-36
Eun, K., Ham, S.W., Kim, H.: Cancer stem cell heterogeneity: origin and new perspectives on CSC targeting. Bmb Rep. 50(3), 117–125–125 (2003). Mar 2017
Sun, Z.A., Wang, L., Dong, L., Wang, X.: Emerging role of exosome signalling in maintaining cancer stem cell dynamic equilibrium. J. Cell Mol. Med. 25 May 2018. https://doi.org/10.1111/jcmm.13676.J
Hernandez-Oller, L.A., Seras-Franzoso, J., Andrade, F., Rafael, D.A., Abasolo, I.A., Gener, P.A., Schwartz, S., AUID-ORCID: https: Extracellular vesicles as drug delivery systems in cancer. Pharmaceutics 12(12) (2012). 26 Nov 2020. https://doi.org/10.3390/pharmaceutics12121146
Jo, D.H., Kim, J.H., Lee, T.G., Kim, J.H.: Size, surface charge, and shape determine therapeutic effects of nanoparticles on brain and retinal diseases. Nanomedicine 7, 1603–1611 (2015)
Meng, H., Leong, W., Leong, K.W., Chen, C., Zhao, Y.: Walking the line: the fate of nanomaterials at biological barriers. Biomaterials 174, 41–53 (2018). Epub 05 May 2018. https://doi.org/10.1016/jbiomaterials.2018.04.056
Rodriguez, P.L., Harada, T., Christian, D.A., Pantano, D.A., Tsai, R.K., Discher, D.E.: Minimal “Self†peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles. Science 339(6122), 971–975. 22 Feb 2013. https://doi.org/10.1126/science 1229568
Mishra, P., Nayak, B., Dey, R.K.: PEGylation in anti-cancer therapy: an overview. AJPS 11, 337–348 (2020)
Libutti, S.K., Tamarkin, L., Nilubol, N.: Targeting the invincible barrier for drug delivery in solid cancers: interstitial fluid pressure. Oncotarget 9(87), 35723-5 (1987). 6 Nov 2018. https://doi.org/10.18632/oncotarget.26267
Miao, L., Newby, J.M., Lin, C., Zhang, L., Xu, F., Kim, W.Y., Forest, M., Lai, S.K., Milowsky, M.I., Wobker, S.E., Huang, L.: The binding site barrier elicited by tumor-associated fibroblasts interferes disposition of nanoparticles in stroma-vessel type tumors. ACS Nano 10(10), 9243–9258 (2010). 25 Oct 2016. Epub 28 Sep 2016. https://doi.org/10.1021/acsnano.6b02776.
Attia, M., Anton, N., Wallyn, J., Omran, Z., Vandamme, T.F.: An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites. J. Pharm. Pharmacol. 1185–1198 (2019)
Murayama, T.F., Gotoh, N.A. Patient-Derived Xenograft Models of Breast Cancer and Their Application. Cells 8(6) (2006). 20 Jun 2019. https://doi.org/10.3390/cells8060621
Dobrovolskaia, M.A., Shurin, M., Shvedova, A.A. Current understanding of interactions between nanoparticles and the immune system. Toxicol. Appl. Pharmacol. 299, 78–89 15 May 2016. Epub 29 Dec 2015. https://doi.org/10.1016/j.taap.2015.12.022
Gazdar, A.F., Hirsch, F.R., Minna, J.D.: From Mice to Men and back – an assessment of preclinical model systems for the study of lung cancers. J. Thorac. Oncol. 11(3), 287–99 (2003). Mar 2016. Epub 24 Dec 2015. https://doi.org/10.1016/j.jtho.2015.10.009
Villaverde, G., Baeza, A.A.: Targeting strategies for improving the efficacy of nanomedicine in oncology. Beilstein J. Nanotechnol. 10, 168–181 14 Jan 2019. https://doi.org/10.3762/bjnano.10.16-Beilstein
Miele, E., Spinelli, G.P., Miele, E., Tomao, F., Tomao, S.: Albumin-bound formulation of paclitaxel (Abraxane® ABI-007) in the treatment of breast cancer. Int. J. Nanomedicine 4, 99–105 2009. Epub 20 Apr 2009
Xu, X., Ho, W., Zhang, X., Bertrand, N., Farokhzad, O.: Cancer Nanomedicine: from targeted delivery to combination therapy. Trends Mol. Med. 21(4), 223–32 (2004). Apr 2015 Epub 2 Feb 2015. https://doi.org/10.1016/j.molmed.2015.01.001.32
Ventola, C.L.: Progress in nanomedicine: approved and investigational nanodrugs. Pharm. Ther. 42(12), 742–755 (2012). 2017 Dec
Patra, J.K., AUID, Das, G., Fraceto, L.F., Campos, E.V.R., Rodriguez-Torres, M., del, P.A., Acosta-Torres, L.S., AUID-ORCID, Diaz-Torres, L.A., AUID-ORCID, Grillo, R., Swamy, M.K., Sharma, S., Habtemariam, S., Shin, H.S.: Nano based drug delivery systems: recent developments and future prospects. J. Nanobiotechnology 16 19 Sep 2018. 10 1186/s12951-018-0392-8
Anchordoquy, T.J., Barenholz, Y., Boraschi, D., Chorny, M., Decuzzi, P., Dobrovolskaia, M.A., Farhangrazi, Z.S., Farrell, D., Gabizon, A., Ghandehari, H., Godin, B., La-Beck, N.M., Ljubimova, J., Moghimi, S.M., Pagliaro, L., Park, J.H., Peer, D., Ruoslahti, E., Serkova, N.J., Simberg, D.: Mechanisms and barriers in cancer nanomedicine: addressing challenges, looking for solutions. ACS Nano. 11(1), 12–18 (2001). 24 Jan 2017. Epub 09 Jan 2017. 10 1021/acsnano 6b08244.
Cicha, I., Chauvierre, C., Texier, I., Cabella, C., Metselaar, J.M., Szebeni, J., Dézsi, L., Alexiou, C., Rouzet, F., Storm, G., Stroes, E., Bruce, D., MacRitchie, N., Maffia, P., Letourneur, D.: From design to the clinic: practical guidelines for translating cardiovascular nanomedicine. Cardiovasc. Res. 114(13), 1714–27 (2013). 01 Nov 2018. Epub 27 Aug 2018. https://doi.org/10.1093/cvr/cvy219-27
Darmont, F., Rousseau, B.: Translation of nanomedicines from lab to industrial scale synthesis: the case of squalene-adenosine nanoparticles. J. Control. Release 307, 302–314 (2019)
Metselaar, J.M., Lammers, T.: Challenges in nanomedicine clinical translation. Drug Deliv. Transl. Res. 10(3), 721–725 (2003) (2020). Epub 12 Mar 2020. https://doi.org/10.1007/s13346-020-00740-5
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Gener, P., Ulldemolins, A., Schwartz, S. (2022). Drawbacks of Bench to Bed Translation of Nanomedicines for Cancer Treatment. In: Balaz, I., Adamatzky, A. (eds) Cancer, Complexity, Computation. Emergence, Complexity and Computation, vol 46. Springer, Cham. https://doi.org/10.1007/978-3-031-04379-6_11
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