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Structure and Function of Mycobacterial Arabinofuranosyltransferases

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Macromolecular Protein Complexes IV

Part of the book series: Subcellular Biochemistry ((SCBI,volume 99))

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Abstract

The mycobacteria genus is responsible for numerous infectious diseases that have afflicted the human race since antiquity—tuberculosis and leprosy in particular. An important contributor to their evolutionary success is their unique cell envelope, which constitutes a quasi-impermeable barrier, protecting the microorganism from external threats, antibiotics included. The arabinofuranosyltransferases are a family of enzymes, unique to the Actinobacteria family that mycobacteria genus belongs to, that are critical to building of this cell envelope. In this chapter, we will analyze available structures of members of the mycobacterial arabinofuranosyltransferase, clarify their function, as well as explore the common themes present amongst this family of enzymes, as revealed by recent research.

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Acknowledgments

This work was supported by National University of Singapore (NUS) Presidential Young Professorship Award, Singapore (A-0008405-00-00 to Y.Z.T.), Ministry of Education (MOE), Singapore (A-8000037-00-00 to Y.Z.T.), Agency for Science Technology and Research (A*STAR), Singapore (to Y.Z.T.), and National Institute of Health (NIH), USA (R35 GM132120 and R21 MH125649 to F.M.).

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Authors and Affiliations

  1. Department of Biological Sciences, National University of Singapore, Singapore, Singapore

    Yong Zi Tan

  2. Disease Intervention Technology Laboratory (DITL), Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore

    Yong Zi Tan

  3. Department of Physiology and Cellular Biophysics, Columbia University, NY, USA

    Filippo Mancia

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  1. Yong Zi Tan
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  2. Filippo Mancia
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Correspondence to Yong Zi Tan .

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Editors and Affiliations

  1. Institute of Molecular Physiology, University of Mainz, Mainz, Germany

    J. Robin Harris

  2. Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK

    Jon Marles-Wright

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Tan, Y.Z., Mancia, F. (2022). Structure and Function of Mycobacterial Arabinofuranosyltransferases. In: Harris, J.R., Marles-Wright, J. (eds) Macromolecular Protein Complexes IV. Subcellular Biochemistry, vol 99. Springer, Cham. https://doi.org/10.1007/978-3-031-00793-4_12

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