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Structure and Dynamics of Bio- and Macromolecules

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Dynamics of Systems on the Nanoscale

Part of the book series: Lecture Notes in Nanoscale Science and Technology ((LNNST,volume 34))

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Abstract

This chapter overviews the computational techniques and theoretical models used for exploring structure and dynamics of complex biomolecular systems at the atomistic level of detail. Particular focus is put on the application of statistical mechanics methods combined with the classical molecular mechanics approach to the description of phase transitions in polypetides and proteins. The molecular mechanics approach permits simulating a large variety of biomacromolecular systems (both in vacuum and in ubiquitous environments) and their transformations at different thermal and biologically relevant conditions as well as at various external stresses. This chapter presents several illustrative examples of such computational research related to protein folding, unbinding of protein-ligand complex, and DNA unzipping.

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Authors and Affiliations

  1. MBN Research Center gGmbH, Altenhöferallee 3, 60438, Frankfurt am Main, Germany

    Alexey V. Verkhovtsev & Andrey V. Solov’yov

  2. Department of Physics, Carl von Ossietzky Universität Oldenburg, Carl-von-Ossietzky-Str. 9-11, 26129, Oldenburg, Germany

    Ilia A. Solov’yov

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  2. Ilia A. Solov’yov
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  3. Andrey V. Solov’yov
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Correspondence to Alexey V. Verkhovtsev .

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Editors and Affiliations

  1. Carl von Ossietzky University Oldenburg, Oldenburg, Germany

    Ilia A. Solov'yov

  2. MBN Research Center, Frankfurt am Main, Germany

    Alexey V. Verkhovtsev

  3. MBN Research Center, Frankfurt am Main, Germany

    Andrei V. Korol

  4. MBN Research Center, Frankfurt am Main, Germany

    Andrey V. Solov'yov

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Verkhovtsev, A.V., Solov’yov, I.A., Solov’yov, A.V. (2022). Structure and Dynamics of Bio- and Macromolecules. In: Solov'yov, I.A., Verkhovtsev, A.V., Korol, A.V., Solov'yov, A.V. (eds) Dynamics of Systems on the Nanoscale. Lecture Notes in Nanoscale Science and Technology, vol 34. Springer, Cham. https://doi.org/10.1007/978-3-030-99291-0_4

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