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GER in Cystic Fibrosis

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Gastroesophageal Reflux in Children

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Abstract

Increased levels of gastroesophageal reflux (GER) are common among people with cystic fibrosis (CF). Multiple intraluminal impedance-pH (MII-pH) studies involving small sample sizes (n = 11–44) of children and adults with CF (not taking anti-reflux medications and no history of fundoplication) have shown that most children and adults with CF experienced increased GER. Among children, 46.4–81% were diagnosed with GERD disease (GERD). Among adults, 66.7–100% had GERD. Approximately two-thirds of the detected GER events were acidic (pH < 4) and a third of these events reached the proximal esophagus. The presence of proximally reaching GER episodes remains a constant concern for clinical management of GER in children and adults with CF. Data from the few available studies suggest that Nissen fundoplication decelerates lung function decline, improves weight gain, and reduces the frequency of pulmonary exacerbations. Future studies are needed to assess the impact of CFTR modulator therapy on GERD in people with CF.

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Authors and Affiliations

  1. Division of Gastroenterology, Center for Neurogastroenterology and Motility Disorders, Nationwide Children’s Hospital, Columbus, OH, USA

    Frederick W. Woodley

  2. Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA

    Frederick W. Woodley & Benjamin T. Kopp

  3. Division of Gastroenterology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Rosara Bass

  4. Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA

    Rosara Bass

  5. Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

    Don Hayes Jr

  6. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA

    Don Hayes Jr

  7. Division of Pulmonary Medicine, Nationwide Children’s Hospital, Columbus, OH, USA

    Benjamin T. Kopp

  8. Center for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children’s Hospital, Columbus, OH, USA

    Benjamin T. Kopp

Authors
  1. Frederick W. Woodley
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  2. Rosara Bass
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  3. Don Hayes Jr
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  4. Benjamin T. Kopp
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Correspondence to Frederick W. Woodley .

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Editors and Affiliations

  1. Vrije Universitiet Brussel (VUB), UZ Brussel KidZ Health Castle, Brussels, Belgium

    Yvan Vandenplas

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Woodley, F.W., Bass, R., Hayes, D., Kopp, B.T. (2022). GER in Cystic Fibrosis. In: Vandenplas, Y. (eds) Gastroesophageal Reflux in Children. Springer, Cham. https://doi.org/10.1007/978-3-030-99067-1_9

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