Skip to main content

Abstract

The colon serves to absorb water and electrolytes, salvage nutrients after bacterial metabolism of carbohydrates, and store intraluminal contents until elimination is socially convenient. These fundamental functions are inextricably dependent on a normal colon’s motor activity. Although there is still limited knowledge about the normal motor patterns, it is clear that altered colonic motility interferes with the colon’s physiological functions and results in gastrointestinal disorders such as constipation.

Colonic manometry provides a direct method for assessing the colon’s neuromuscular integrity by measuring intraluminal pressures and coordination of the colonic muscle pressure activity and has greatly enhanced our knowledge of colonic motor physiology and pathophysiology of constipation.

Even though primarily restricted to specialized centers, colonic manometry should be considered an essential diagnostic tool to guide the management of children with intractable constipation, mainly when surgical intervention is being considered.

This chapter summarizes the recent advances in colonic manometry, including indications and preparation for the study and how to perform and interpret the test in children.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Bleier JIS, Wilkins KB. Colonic physiology. In: Steele S, Hull T, Read T, Saclarides T, Senagore A, Whitlow C, editors. The ASCRS textbook of colon and Rectal surgery. Cham: Springer; 2016. p. P27–35.

    Chapter  Google Scholar 

  2. Corsetti M, Costa M, Bassotti G, Bharucha AE, Borrelli O, Dinning P, et al. First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques. Nat Rev Gastroenterol Hepatol. 2019;16:559–79.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Tambucci R, Quitadamo P, Thapar N, Zenzeri L, Caldaro T, Staiano A, et al. Diagnostic tests in pediatric constipation. J Pediatr Gastroenterol Nutr. 2018;66:e89–98.

    Article  PubMed  Google Scholar 

  4. Camilleri M, Bharucha AE, di Lorenzo C, Hasler WL, Prather CM, Rao SS, Wald A. American Neurogastroenterology and Motility Society consensus statement on intraluminal measurement of gastrointestinal and colonic motility in clinical practice. Neurogastroenterol Motil. 2008;20:1269–82.

    Article  CAS  PubMed  Google Scholar 

  5. Rodriguez L, Sood M, Di Lorenzo C, Saps M. An ANMS-NASPGHAN consensus document on anorectal and colonic manometry in children. Neurogastroenterol Motil. 2017;29

    Google Scholar 

  6. Rao SS, Sadeghi P, Beaty J, Kavlock R, Ackerson K. Ambulatory 24-h colonic manometry in healthy humans. Am J Physiol Gastrointest Liver Physiol. 2001;280:629–39.

    Article  Google Scholar 

  7. Dinning PG, Carrington EV, Scott SM. The use of colonic and anorectal high-resolution manometry and its place in clinical work and in research. Neurogastroenterol Motil. 2015;27:1693–708.

    Article  CAS  PubMed  Google Scholar 

  8. Tabbers MM, Di Lorenzo C, Berger MY, Faure C, Langendam MW, Nurko S, et al. Evaluation and treatment of functional constipation in infants and children: evidence-based recommendations from ESPGHAN and NASPGHAN. J Pediatr Gastroenterol Nutr. 2014;58:258–74.

    Article  CAS  PubMed  Google Scholar 

  9. Bharucha AE, Pemberton JH, Locke GR 3rd. American Gastroenterological Association technical review on constipation. Gastroenterology. 2013;144:218–38.

    Article  PubMed  Google Scholar 

  10. Dinning PG, Wiklendt L, Gibbins I, Patton V, Bampton P, Lubowski DZ, et al. Low-resolution colonic manometry leads to a gross misinterpretation of the frequency and polarity of propagating sequences: initial results from fiber-optic high-resolution manometry studies. Neurogastroenterol Motil. 2013;25:640–9.

    Google Scholar 

  11. El-Chammas KI, Tipnis NA, Simpson PM, Sood MR. Colon high-resolution manometry: using pressure topography plots to evaluate pediatric colon motility. J Pediatr Gastroenterol Nutr. 2014;59:500–4.

    Article  PubMed  Google Scholar 

  12. Lee YY, Erdogan A, Rao SS. How to perform and assess colonic manometry and barostat study in chronic constipation. J Neurogastroenterol Motil. 2014;20:547–52.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Dinning PG, Benninga MA, Southwell BR, Scott SM. Paediatric and adult colonic manometry: a tool to help unravel the pathophysiology of constipation. World J Gastroenterol. 2010;16:5162–72.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Sanghavi RM, Centeno RM, Barth B. Single balloon-assisted colonoscopy for placement of colonic manometry catheters: initial experience in children. J Pediatr Gastroenterol Nutr. 2018;67:194–7.

    Article  PubMed  Google Scholar 

  15. Di Lorenzo C, Flores AF, Hyman PE. Age-related changes in colon motility. J Pediatr. 1995;127:593–6.

    Article  PubMed  Google Scholar 

  16. Rao SS, Sadeghi P, Beaty J, Kavlock R. Ambulatory 24-hour colonic manometry in slow-transit constipation. Am J Gastroenterol. 2004;99:2405–16.

    Article  PubMed  Google Scholar 

  17. Dinning PG, Wiklendt L, Maslen L, Gibbins I, Patton V, Arkwright JW, et al. Quantification of in vivo colonic motor patterns in healthy humans before and after a meal revealed by high-resolution fiber-optic manometry. Neurogastroenterol Motil. 2014;26:1443–57.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Dinning PG, Szczesniak MM, Cook IJ. Proximal colonic propagating pressure waves sequences and their relationship with movements of content in the proximal human colon. Neurogastroenterol Motil. 2008;20:512–20.

    Article  CAS  PubMed  Google Scholar 

  19. Dinning PG, Wiklendt L, Maslen L, Patton V, Lewis H, Arkwright JW, et al. Colonic motor abnormalities in slow transit constipation defined by high resolution, fibre-optic manometry. Neurogastroenterol Motil. 2015;27:379–88.

    Article  CAS  PubMed  Google Scholar 

  20. Bharucha AE. High amplitude propagated contractions. Neurogastroenterol Motil. 2012;24:977–82.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Rodriguez L, Siddiqui A, Nurko S. Internal anal sphincter relaxation associated with bisacodyl-induced colonic high amplitude propagating contractions in children with constipation: a Colo-anal reflex? Neurogastroenterol Motil. 2012;24:1023–e545.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Sintusek P, Rybak A, Mutalib M, Thapar N, Borrelli O, Lindley KJ. Preservation of the Colo-anal reflex in colonic transection and postoperative Hirschsprung’s disease: potential extrinsic neural pathway. Neurogastroenterol Motil. 2019;31:e13472.

    Article  PubMed  Google Scholar 

  23. Kaul A, Garza JM, Connor FL, Cocjin JT, Flores AF, Hyman PE, et al. Colonic hyperactivity results in frequent fecal soiling in a subset of children after surgery for Hirschsprung disease. J Pediatr Gastroenterol Nutr. 2011;52:433–6.

    Article  PubMed  Google Scholar 

  24. Hagger R, Kumar D, Benson M, Grundy A. Colonic motor activity in slow-transit idiopathic constipation as identified by 24-h pancolonic ambulatory manometry. Neurogastroenterol Mot. 2003;15:515–22.

    Article  CAS  Google Scholar 

  25. Di Lorenzo C, Flores AF, Reddy SN, Hyman PE. Use of colonic manometry to differentiate causes of intractable constipation in children. J Pediatr. 1992;120:690–5.

    Article  PubMed  Google Scholar 

  26. Dinning PG, Zarate N, Hunt LM, Fuentealba SE, Mohammed SD, Szczesniak MM, et al. Pancolonic spatiotemporal mapping reveals regional deficiencies in, and disorganization of colonic propagating pressure waves in severe constipation. Neurogastroenterol Motil. 2010;22:340–9.

    Article  Google Scholar 

  27. Giorgio V, Borrelli O, Smith VV, Rampling D, Köglmeier J, Shah N, et al. High-resolution colonic manometry accurately predicts colonic neuromuscular pathological phenotype in pediatric slow transit constipation. Neurogastroenterol Motil. 2013;25:70–8.

    Article  CAS  PubMed  Google Scholar 

  28. Dinning PG, Di Lorenzo C. Colonic dysmotility in constipation. Best Pract Res Clin Gastroenterol. 2011;25:89–101.

    Article  PubMed  Google Scholar 

  29. Pensabene L, Youssef NN, Griffiths JM, Di Lorenzo C. Colonic manometry in children with defecatory disorders. Role in diagnosis and management. Am J Gastroenterol. 2003;98:1052–7.

    PubMed  Google Scholar 

  30. Hamid SA, Di Lorenzo C, Reddy SN, Flores AF, Hyman PE. Bisacodyl and high-amplitude-propagating colonic contractions in children. J Pediatr Gastroenterol Nutr. 1998;27:398–402.

    Article  CAS  PubMed  Google Scholar 

  31. Borrelli O, Pescarin M, Saliakellis E, Tambucci R, Quitadamo P, Valitutti F, et al. Sequential incremental doses of bisacodyl increase the diagnostic accuracy of colonic manometry. Neurogastroenterol Motil. 2016;28:1747–55.

    Article  CAS  PubMed  Google Scholar 

  32. Heitmann PT, Wiklendt L, Thapar N, Borrelli O, Di Lorenzo C, Yacob DT, et al. Characterization of the colonic response to bisacodyl in children with treatment-refractory constipation. Neurogastroenterol Motil. 2020;32:e13851.

    CAS  PubMed  Google Scholar 

  33. Bassotti G, Clementi M, Antonelli E, Pelli MA, Tonini M. Low amplitude propagated contractile waves: a relevant propulsive mechanism of human colon. Dig Liver Dis. 2001;33:36–40.

    Article  CAS  PubMed  Google Scholar 

  34. Martin MJ, Steele SR, Mullenix PS, Noel JM, Weichmann D, Azarow KS. A pilot study using total colonic manometry in the surgical evaluation of pediatric functional colonic obstruction. J Pediatr Surg. 2004;39:352–9.

    Article  PubMed  Google Scholar 

  35. Bassotti G, Chiarioni G, Imbimbo BP, Betti C, Bonfante F, Vantini I, et al. Impaired colonic motor response to cholinergic stimulation in patients with severe chronic idiopathic (slow transit type) constipation. Dig Dis Sci. 1993;38:1040–5.

    Article  CAS  PubMed  Google Scholar 

  36. Preston DM, Lennard-Jones JE. Pelvic motility and response to intraluminal bisacodyl in slow-transit constipation. Dig Dis Sci. 1985;30:289–94.

    Article  CAS  PubMed  Google Scholar 

  37. Dinning PG, Bampton PA, Kennedy ML, Lubowski DZ, King D, Cook IJ. Impaired proximal colonic motor response to rectal mechanical and chemical stimulation in obstructed defecation. Dis Colon Rectum. 2005;48:1777–84.

    Article  PubMed  Google Scholar 

  38. Van den Berg MM, Hogan M, Caniano DA, Di Lorenzo C, Benninga MA, Mousa HM. Colonic manometry as predictor of cecostomy success in children with defecation disorders. J Pediatr Surg. 2006;41:730–6.

    Article  PubMed  Google Scholar 

  39. Villarreal J, Sood M, Zangen T, Flores A, Michel R, Reddy N, et al. Colonic diversion for intractable constipation in children: colonic manometry helps guide clinical decisions. J Pediatr Gastroenterol Nutr. 2001;33:588–91.

    Article  CAS  PubMed  Google Scholar 

  40. Gasior A, Reck C, Vilanova-Sanchez A, Diefenbach KA, Yacob D, Lu P, et al. Surgical management of functional constipation: an intermediate report of a new approach using a laparoscopic sigmoid resection combined with Malone appendicostomy. J Pediatr Surg. 2018;53:1160–2.

    Article  PubMed  Google Scholar 

  41. Gupta A, Basson S, Borrelli O, Lindley K, Thapar N, Saliakellis E, et al. Surgically treated intractable constipation in children evaluated with colonic manometry. J Pediatr Surg. 2020;55:265–8.

    Article  PubMed  Google Scholar 

  42. Rodriguez L, Heinz N, Nurko S. Utility of colon manometry in guiding therapy and predicting need for surgery in children with defecation disorders. J Pediatr Gastroenterol Nutr. 2020;70:232–7.

    Article  PubMed  Google Scholar 

  43. Rodriguez L, Nurko S, Flores A. Factors associated with successful decrease and discontinuation of antegrade continence enemas (ACE) in children with defecation disorders: a study evaluating the effect of ACE on colon motility. Neurogastroenterol Motil. 2013;25:140–e81.

    Article  CAS  PubMed  Google Scholar 

  44. Aspirot A, Fernandez S, Di Lorenzo C, Skaggs B, Mousa H. Antegrade enemas for defecation disorders: do they improve the colonic motility? J Pediatr Surg. 2009;44:1575–80.

    Article  PubMed  Google Scholar 

  45. Di Lorenzo C, Solzi GF, Flores AF, Schwankovsky L, Hyman PE. Colonic motility after surgery for Hirschsprung’s disease. Am J Gastroenterol. 2000;95:1759–64.

    Article  PubMed  Google Scholar 

  46. Heikenen JB, Werlin SL, Di Lorenzo C, Hyman PE, Cocjin J, Flores AF, et al. Colonic motility in children with repaired imperforate anus. Dig Dis Sci. 1999;44:1288–92.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Renato Tambucci .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Tambucci, R., Borrelli, O. (2022). Colonic Manometry. In: Lima, M., Ruggeri, G. (eds) Ano-Rectal Endosonography and Manometry in Paediatrics. Springer, Cham. https://doi.org/10.1007/978-3-030-97668-2_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-97668-2_7

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-97667-5

  • Online ISBN: 978-3-030-97668-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics