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Perfluorocarbon-Based Oxygen Carriers

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Book cover Blood Substitutes and Oxygen Biotherapeutics

Abstract

Artificial oxygen ca obtain a stable mixture. Perfluorocarbons rriers are classified into two broad categories: hemoglobin-based and perfluorocarbon-based. Both provide oxygen transport to tissues. For several decades, perfluorocarbons have been explored as oxygen carriers in a variety of biological applications. Perfluorocarbons are chemically and physiologically inert, have excellent temperature and storage stability, represent little to no infectious danger, are commercially available, and have well-established gas transport qualities. Perfluorocarbons are compounds that have high solubility for many gases, but they are not suitable for direct injection into the vascular system and require emulsification to obtain a stable mixture. Perfluorocarbons may be classified into five categories based on the primary perfluorocarbon backbone utilized in the product: (1) perfluorodecalin, (2) perfluorooctyll bromide, (3) tertbutylperfluorocyclohexane, (4) dodecafluoropentane, and (5) perftoran. When combined with other blood-saving strategies, the use of perfluorocarbon-based oxygen carriers enables the performance of surgical procedures with increased blood loss while eliminating or lowering the need for allogeneic transfusion. Other applications have been described and are under investigation.

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Authors and Affiliations

  1. Department of Anesthesiology and Department of Pharmacology, Toxicology, and Neurosciences, LSU School of Medicine, Shreveport, LA, USA

    Alan D. Kaye

  2. Department of Anesthesiology and Pharmacology, LSU School of Medicine, New Orleans, LA, USA

    Alan D. Kaye

  3. Department of Anesthesiology and Pharmacology, Tulane School of Medicine, New Orleans, LA, USA

    Alan D. Kaye

  4. Department of Surgery, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, TX, USA

    Karla Samaniego

  5. Department of Cellular Biology and Anatomy, Louisiana State University Health Shreveport, Shreveport, LA, USA

    Sumitra Miriyala

  6. Louisiana State University Health Shreveport, Shreveport, LA, USA

    Benjamin C. Miller

  7. Department of Anesthesiology, LSU Health Shreveport, Shreveport, LA, USA

    Elyse M. Cornett

  8. Departments of Medicine, Emergency Medicine, Pediatrics and Surgery, Louisiana State University Health Shreveport, Shreveport, LA, USA

    Steven A. Conrad

Authors
  1. Alan D. Kaye
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  2. Karla Samaniego
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  3. Sumitra Miriyala
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  4. Benjamin C. Miller
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  5. Elyse M. Cornett
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  6. Steven A. Conrad
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Corresponding author

Correspondence to Alan D. Kaye .

Editor information

Editors and Affiliations

  1. Anesthesiology & Critical Care, University of Pennsylvania, Philadelphia, PA, USA

    Henry Liu

  2. Department of Anesthesiology and Department of Pharmacology, Toxicology, and Neurosciences LSU School of Medicine, Shreveport, LA, USA

    Alan D. Kaye

  3. Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    Jonathan S. Jahr

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Kaye, A.D., Samaniego, K., Miriyala, S., Miller, B.C., Cornett, E.M., Conrad, S.A. (2022). Perfluorocarbon-Based Oxygen Carriers. In: Liu, H., Kaye, A.D., Jahr, J.S. (eds) Blood Substitutes and Oxygen Biotherapeutics. Springer, Cham. https://doi.org/10.1007/978-3-030-95975-3_16

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  • DOI: https://doi.org/10.1007/978-3-030-95975-3_16

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-95974-6

  • Online ISBN: 978-3-030-95975-3

  • eBook Packages: MedicineMedicine (R0)

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