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Volume and Blood Management

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Textbook of Polytrauma Management

Abstract

Traumatic bleeding is still the main preventable cause of death in severely injured patients. Beside surgical care, trauma resuscitation also aims to detect and treat systemic coagulation disorders as early as possible in order to counteract coagulopathy and stabilize the patient. Initial trauma resuscitation includes restrictive, goal-directed volume resuscitation using crystalloid solutions and vasopressors on demand to maintain the circulation at a low-stable level. A goal-directed factor-based coagulation management was shown to improve outcomes and lower mortality following major trauma and is therefore recommended in first line. This approach requires a predefined coagulation algorithm including repetitive point-of-care measurements as well as a restrictive transfusion management. The increasing use of oral anticoagulants is additionally challenging trauma treatment. Residual effects of anticoagulants should be assessed and quantified quickly with suitable laboratory tests and reversed in case of an ongoing bleeding.

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References

  1. Moore L, Evans D, Hameed SM, Yanchar NL, Stelfox HT, Simons R, et al. Mortality in Canadian trauma systems: a multicenter cohort study. Ann Surg. 2017;265(1):212–7. https://doi.org/10.1097/SLA.0000000000001614.

    Article  PubMed  Google Scholar 

  2. Spahn DR, Bouillon B, Cerny V, Duranteau J, Filipescu D, Hunt BJ, et al. The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition. Crit Care. 2019;23(1):98. https://doi.org/10.1186/s13054-019-2347-3.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Duque P, Mora L, Levy JH, Schochl H. Pathophysiological response to trauma-induced coagulopathy: a comprehensive review. Anesth Analg. 2019; https://doi.org/10.1213/ANE.0000000000004478.

  4. Kind SL, Spahn-Nett GH, Emmert MY, Eismon J, Seifert B, Spahn DR, et al. Is dilutional coagulopathy induced by different colloids reversible by replacement of fibrinogen and factor XIII concentrates? Anesth Analg. 2013;117(5):1063–71. https://doi.org/10.1213/ANE.0b013e3182a52876.

    Article  CAS  PubMed  Google Scholar 

  5. Theusinger OM, Wanner GA, Emmert MY, Billeter A, Eismon J, Seifert B, et al. Hyperfibrinolysis diagnosed by rotational thromboelastometry (ROTEM) is associated with higher mortality in patients with severe trauma. Anesth Analg. 2011;113(5):1003–12. https://doi.org/10.1213/ANE.0b013e31822e183f.

    Article  PubMed  Google Scholar 

  6. Stein P, Studt JD, Albrecht R, Muller S, von Ow D, Fischer S, et al. The impact of prehospital tranexamic acid on blood coagulation in trauma patients. Anesth Analg. 2018;126(2):522–9. https://doi.org/10.1213/ANE.0000000000002708.

    Article  CAS  PubMed  Google Scholar 

  7. Spahn DR, Munoz M, Klein AA, Levy JH, Zacharowski K. Patient blood management: effectiveness and future potential. Anesthesiology. 2020; https://doi.org/10.1097/ALN.0000000000003198.

  8. Theusinger OM, Stein P, Spahn DR. Applying 'Patient blood Management' in the trauma center. Curr Opin Anaesthesiol. 2014;27(2):225–32. https://doi.org/10.1097/ACO.0000000000000041.

    Article  PubMed  Google Scholar 

  9. Siam J, Kadan M, Flaishon R, Barnea O. Blood flow versus hematocrit in optimization of oxygen transfer to tissue during fluid resuscitation. Cardiovasc Eng Technol. 2015;6(4):474–84. https://doi.org/10.1007/s13239-015-0237-7.

    Article  PubMed  Google Scholar 

  10. Boer C, Bossers SM, Koning NJ. Choice of fluid type: physiological concepts and perioperative indications. Br J Anaesth. 2018;120(2):384–96. https://doi.org/10.1016/j.bja.2017.10.022.

    Article  CAS  PubMed  Google Scholar 

  11. Chatrath V, Khetarpal R, Ahuja J. Fluid management in patients with trauma: restrictive versus liberal approach. J Anaesthesiol Clin Pharmacol. 2015;31(3):308–16. https://doi.org/10.4103/0970-9185.161664.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Kabon B, Sessler DI, Kurz A, Crystalloid-Colloid Study T. Effect of intraoperative goal-directed balanced crystalloid versus colloid administration on major postoperative morbidity: a randomized trial. Anesthesiology. 2019;130(5):728–44. https://doi.org/10.1097/ALN.0000000000002601.

    Article  PubMed  Google Scholar 

  13. Zhong JZ, Wei D, Pan HF, Chen YJ, Liang XA, Yang ZY, et al. Colloid solutions for fluid resuscitation in patients with sepsis: systematic review of randomized controlled trials. J Emerg Med. 2013;45(4):485–95. https://doi.org/10.1016/j.jemermed.2013.05.018.

    Article  PubMed  Google Scholar 

  14. Perel P, Roberts I, Ker K. Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev 2013;2(2):CD000567. doi:https://doi.org/10.1002/14651858.CD000567.pub6.

  15. Phillips DP, Kaynar AM, Kellum JA, Gomez H. Crystalloids vs. colloids: KO at the twelfth round? Crit Care. 2013;17(3):319. https://doi.org/10.1186/cc12708.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Sawhney C, Subramanian A, Kaur M, Anjum A, Albert V, Soni KD, et al. Assessment of hemostatic changes after crystalloid and colloid fluid preloading in trauma patients using standard coagulation parameters and thromboelastography. Saudi J Anaesth. 2013;7(1):48–56. https://doi.org/10.4103/1658-354X.109809.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Stein P, Kaserer A, Sprengel K, Wanner GA, Seifert B, Theusinger OM, et al. Change of transfusion and treatment paradigm in major trauma patients. Anaesthesia. 2017;72(11):1317–26. https://doi.org/10.1111/anae.13920.

    Article  CAS  PubMed  Google Scholar 

  18. Finfer S, Bellomo R, Boyce N, French J, Myburgh J, Norton R, et al. A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med. 2004;350(22):2247–56. https://doi.org/10.1056/NEJMoa040232.

    Article  CAS  PubMed  Google Scholar 

  19. Yunos NM, Kim IB, Bellomo R, Bailey M, Ho L, Story D, et al. The biochemical effects of restricting chloride-rich fluids in intensive care. Crit Care Med. 2011;39(11):2419–24. https://doi.org/10.1097/CCM.0b013e31822571e5.

    Article  CAS  PubMed  Google Scholar 

  20. Self WH, Semler MW, Wanderer JP, Wang L, Byrne DW, Collins SP, et al. Balanced crystalloids versus saline in noncritically ill adults. N Engl J Med. 2018;378(9):819–28. https://doi.org/10.1056/NEJMoa1711586.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Semler MW, Self WH, Wanderer JP, Ehrenfeld JM, Wang L, Byrne DW, et al. Balanced crystalloids versus saline in critically ill adults. N Engl J Med. 2018;378(9):829–39. https://doi.org/10.1056/NEJMoa1711584.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Meier J, Kemming GI, Kisch-Wedel H, Wolkhammer S, Habler OP. Hyperoxic ventilation reduces 6-hour mortality at the critical hemoglobin concentration. Anesthesiology. 2004;100(1):70–6. https://doi.org/10.1097/00000542-200401000-00014.

    Article  CAS  PubMed  Google Scholar 

  23. de Araujo Azi LM, Lopes FM, Garcia LV. Postoperative management of severe acute anemia in a Jehovah's witness. Transfusion. 2014;54(4):1153–7. https://doi.org/10.1111/trf.12424.

    Article  PubMed  Google Scholar 

  24. Spahn DR, Spahn GH, Stein P. Evidence base for restrictive transfusion triggers in high-risk patients. Transfus Med Hemother. 2015;42(2):110–4. https://doi.org/10.1159/000381509.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Stolla M, Zhang F, Meyer MR, Zhang J, Dong JF. Current state of transfusion in traumatic brain injury and associated coagulopathy. Transfusion. 2019;59(S2):1522–8. https://doi.org/10.1111/trf.15169.

    Article  PubMed  Google Scholar 

  26. Desborough MJR, Colman KS, Prick BW, Duvekot JJ, Sweeney C, Odutayo A, et al. Effect of restrictive versus liberal red cell transfusion strategies on haemostasis: systematic review and meta-analysis. Thromb Haemost. 2017;117(5):889–98. https://doi.org/10.1160/TH17-01-0015.

    Article  PubMed  Google Scholar 

  27. Hebert PC, Carson JL. Transfusion threshold of 7 g per deciliter—the new normal. N Engl J Med. 2014;371(15):1459–61. https://doi.org/10.1056/NEJMe1408976.

    Article  PubMed  Google Scholar 

  28. Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, et al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. JAMA. 2015;313(5):471–82. https://doi.org/10.1001/jama.2015.12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Gonzalez E, Moore EE, Moore HB, Chapman MP, Chin TL, Ghasabyan A, et al. Goal-directed hemostatic resuscitation of trauma-induced coagulopathy: a pragmatic randomized clinical trial comparing a viscoelastic assay to conventional coagulation assays. Ann Surg. 2016;263(6):1051–9. https://doi.org/10.1097/SLA.0000000000001608.

    Article  PubMed  Google Scholar 

  30. Schochl H, Nienaber U, Hofer G, Voelckel W, Jambor C, Scharbert G, et al. Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate. Crit Care. 2010;14(2):R55. https://doi.org/10.1186/cc8948.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Baksaas-Aasen K, Van Dieren S, Balvers K, Juffermans NP, Naess PA, Rourke C, et al. Data-driven development of ROTEM and TEG algorithms for the management of trauma hemorrhage: a prospective observational multicenter study. Ann Surg. 2018; https://doi.org/10.1097/SLA.0000000000002825.

  32. Kaserer A, Casutt M, Sprengel K, Seifert B, Spahn DR, Stein P. Comparison of two different coagulation algorithms on the use of allogenic blood products and coagulation factors in severely injured trauma patients: a retrospective, multicentre, observational study. Scand J Trauma Resusc Emerg Med. 2018;26(1):4. https://doi.org/10.1186/s13049-017-0463-0.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Innerhofer P, Fries D, Mittermayr M, Innerhofer N, von Langen D, Hell T, et al. Reversal of trauma-induced coagulopathy using first-line coagulation factor concentrates or fresh frozen plasma (RETIC): a single-Centre, parallel-group, open-label, randomised trial. Lancet Haematol. 2017;4(6):e258–e71. https://doi.org/10.1016/S2352-3026(17)30077-7.

    Article  PubMed  Google Scholar 

  34. Scharbert G, Wetzel L, Schrottmaier WC, Kral JB, Weber T, Assinger A. Comparison of patient intake of ticagrelor, prasugrel, or clopidogrel on restoring platelet function by donor platelets. Transfusion. 2015;55(6):1320–6. https://doi.org/10.1111/trf.12977.

    Article  CAS  PubMed  Google Scholar 

  35. Stein P, Kaserer A, Spahn GH, Spahn DR. Point-of-care coagulation monitoring in trauma patients. Semin Thromb Hemost. 2017;43(4):367–74. https://doi.org/10.1055/s-0037-1598062.

    Article  PubMed  Google Scholar 

  36. Schochl H, Nienaber U, Maegele M, Hochleitner G, Primavesi F, Steitz B, et al. Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy. Crit Care. 2011;15(2):R83. https://doi.org/10.1186/cc10078.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Stein AL, Rossler J, Braun J, Sprengel K, Beeler PE, Spahn DR, et al. Impact of a goal-directed factor-based coagulation management on thromboembolic events following major trauma. Scand J Trauma Resusc Emerg Med. 2019;27(1):117. https://doi.org/10.1186/s13049-019-0697-0.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Roberts I, Shakur H, Coats T, Hunt B, Balogun E, Barnetson L, et al. The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. Health Technol Assess. 2013;17(10):1–79. https://doi.org/10.3310/hta17100.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Benipal S, Santamarina JL, Vo L, Nishijima DK. Mortality and thrombosis in injured adults receiving tranexamic acid in the post-CRASH-2 era. West J Emerg Med. 2019;20(3):443–53. https://doi.org/10.5811/westjem.2019.4.41698.

    Article  PubMed  PubMed Central  Google Scholar 

  40. collaborators C-t. Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial. Lancet. 2019;394(10210):1713–23. https://doi.org/10.1016/S0140-6736(19)32233-0.

    Article  Google Scholar 

  41. Grassin-Delyle S, Theusinger OM, Albrecht R, Mueller S, Spahn DR, Urien S, et al. Optimisation of the dosage of tranexamic acid in trauma patients with population pharmacokinetic analysis. Anaesthesia. 2018;73(6):719–29. https://doi.org/10.1111/anae.14184.

    Article  CAS  PubMed  Google Scholar 

  42. Kaserer A, Kiavialaitis GE, Braun J, Schedler A, Stein P, Rossler J, et al. Impact of rivaroxaban plasma concentration on perioperative red blood cell loss. Transfusion. 2020;60(1):197–205. https://doi.org/10.1111/trf.15560.

    Article  CAS  PubMed  Google Scholar 

  43. Kaserer A, Schedler A, Seifert B, Spahn DR, Studt JD, Stein P. Standard coagulation assays alone are not sufficient to exclude surgically relevant rivaroxaban plasma concentrations. Perioper Med (Lond). 2019;8(1):15. https://doi.org/10.1186/s13741-019-0128-9.

    Article  Google Scholar 

  44. Brekelmans MPA, Ginkel KV, Daams JG, Hutten BA, Middeldorp S, Coppens M. Benefits and harms of 4-factor prothrombin complex concentrate for reversal of vitamin K antagonist associated bleeding: a systematic review and meta-analysis. J Thromb Thrombolysis. 2017;44(1):118–29. https://doi.org/10.1007/s11239-017-1506-0.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Connolly SJ, Milling TJ Jr, Eikelboom JW, Gibson CM, Curnutte JT, Gold A, et al. Andexanet alfa for acute major bleeding associated with factor Xa inhibitors. N Engl J Med. 2016;375(12):1131–41. https://doi.org/10.1056/NEJMoa1607887.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Sokol J, Nehaj F, Ivankova J, Mokan M, Mokan M. First evidence: rivaroxaban and apixaban reduce thrombin-dependent platelet aggregation. J Thromb Thrombolysis. 2018;46(3):393–8. https://doi.org/10.1007/s11239-018-1709-z.

    Article  CAS  PubMed  Google Scholar 

  47. Pollack CV Jr, Reilly PA, van Ryn J, Eikelboom JW, Glund S, Bernstein RA, et al. Idarucizumab for dabigatran reversal - full cohort analysis. N Engl J Med. 2017;377(5):431–41. https://doi.org/10.1056/NEJMoa1707278.

    Article  CAS  PubMed  Google Scholar 

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Kaserer, A., Rössler, J., Spahn, D.R. (2022). Volume and Blood Management. In: Pape, HC., Borrelli Jr., J., Moore, E.E., Pfeifer, R., Stahel, P.F. (eds) Textbook of Polytrauma Management . Springer, Cham. https://doi.org/10.1007/978-3-030-95906-7_7

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