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Regenerative Rehabilitation pp 227–249Cite as

Novel Cell-Based Therapeutics for Diseases of the Heart and Skeletal Muscle

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Part of the Physiology in Health and Disease book series (PIHD)

Abstract

Diseases of the heart and skeletal muscle represent a major cause of mortality and morbidity in the United States. Many, if not most, are refractory to contemporary medical approaches, which rarely address the root pathogenesis. Regenerative medicine is a specialized field focused on replacing or repairing damaged tissue, which is otherwise incapable of self-healing. For more than four decades, stem and progenitor cells have been recognized for their potential as therapeutic products for regenerative medicine. Despite the long history of scientific inquiry, no cell therapy product has received regulatory approval for regenerative medicine applications in the United States. Recent initiatives focused on understanding the mechanistic basis of cell therapy have fundamentally redirected the trajectory of their development. In doing so, a class of extracellular vesicles called exosomes have emerged as next-generation therapeutic candidates for regenerative medicine. In this chapter, we discuss the difficulties with the commercial development of cell therapy products and the promise of exosomes as next-generation therapeutics. The field of regenerative medicine is ever-changing, and the latest technological advances continue to define our path forward.

Keywords

  • Cell therapy
  • Exosomes
  • Heart disease
  • Regenerative medicine
  • Skeletal muscle disease

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Authors and Affiliations

  1. Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Russell G. Rogers & Eduardo Marbán

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  1. Russell G. Rogers
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  2. Eduardo Marbán
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Correspondence to Eduardo Marbán .

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  1. School of Kinesiology, University of Minnesota, Minneapolis, MN, USA

    Assist. Prof. Sarah M. Greising

  2. Department of Kinesiology, University of Georgia, Athens, GA, USA

    Assoc. Prof. Jarrod A. Call

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Rogers, R.G., Marbán, E. (2022). Novel Cell-Based Therapeutics for Diseases of the Heart and Skeletal Muscle. In: Greising, S.M., Call, J.A. (eds) Regenerative Rehabilitation. Physiology in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-95884-8_7

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