Not only are the costs of medicines high, which is why prescription medicines alone account for the third largest cost factor in the healthcare system, but the costs and risks for the pharmaceutical industry have also exploded. At the same time, the industry seems to be running out of ideas, which I see as one of the key symptoms of the crisis in medicine. This is where the concept of defining symptoms as disease and the treatment of symptoms as therapy was the first to suffer shipwreck. At least at the level of drug approval or negotiations with health insurance companies, every new drug is compared with existing drugs for every indication. If no real advantage is apparent, then such new developments fail or at least do not generate the sales revenues they would have to generate to recoup the previous costs and the costs of all failed projects of the same company.