Abstract
There are clearly different techniques for the diagnosis of cerebrospinal fluid (CSF) rhinorrhea—and these techniques have evolved over time. There is some good evidence supporting the effectiveness of certain methods, however experience also plays a role since the evidence is not high-level or definitive. That statement is not a critique of the authors that have published on the topic; rather, it is a reflection of the rarity of the condition, and the difficulty in performing true randomized or controlled trials in this diagnosis. We have divided this section of the chapter into discussion on the diagnosis of CSF rhinorrhea—whether or not it is present—and the localization of the leak—after the diagnosis has been established—and a section on intrathecal fluorescein, which is used for both diagnosis and localization.
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Lieberman, S.M., Stewart, M.G. (2022). Evidence-Based Medicine in Cerebrospinal Fluid Leak and Skull Base Reconstruction. In: AlQahtani, A.A., Castelnuovo, P., Casiano, R., Carrau, R.L. (eds) CSF Rhinorrhea. Springer, Cham. https://doi.org/10.1007/978-3-030-94781-1_37
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