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Role and Regulation of Hepatic Metabolism During Exercise

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Exercise Metabolism

Part of the book series: Physiology in Health and Disease ((PIHD))

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Abstract

The liver is a rechargeable battery. It releases stored energy at times of high metabolic demand such as exercise and replenishes energy stores in response to a meal. The liver is a recycler. It converts metabolites and amino acids into glucose. The liver is a detoxifier. It removes nitrogenous molecules, hemoglobin, hormones, foreign substances, immunoglobulin, and other compounds from the circulation. The muscle contracts, the adipose tissue stores fat, and the heart pumps blood. The functions of the liver are far too diverse to define by a single dominant process. The underlying role of the functions of the liver is that they make broad contributions to arterial homeostasis and thereby homeostasis of numerous cell types. Physical exercise poses a unique challenge to the liver as metabolic demands of working muscles require the liver to mobilize energy stores, recycle metabolites, and convert compounds that are toxic in excess to innocuous forms. The focus of this review will be on how the liver adapts to the metabolic demands of physical exercise.

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Acknowledgments

The authors acknowledge grants DK050277, DK054902, and DK059637 from the National Institutes of Health.

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  1. Molecular and Cellular Biological Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA

    Elijah Trefts

  2. Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA

    David H. Wasserman

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Correspondence to David H. Wasserman .

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  1. Victoria University, Melbourne, VIC, Australia

    Glenn McConell

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Trefts, E., Wasserman, D.H. (2022). Role and Regulation of Hepatic Metabolism During Exercise. In: McConell, G. (eds) Exercise Metabolism. Physiology in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-94305-9_11

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