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Macropinocytosis and Cancer: From Tumor Stress to Signaling Pathways

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Macropinocytosis

Part of the book series: Subcellular Biochemistry ((SCBI,volume 98))

Abstract

Macropinocytosis is an evolutionarily conserved endocytic pathway that mediates the nonselective acquisition of extracellular material via large endocytic vesicles known as macropinosomes. In addition to other functions, this uptake pathway supports cancer cell metabolism through the uptake of nutrients. Cells harboring oncogene or tumor suppressor mutations are known to display heightened macropinocytosis, which confers to the cancer cells the ability to survive and proliferate despite the nutrient-scarce conditions of the tumor microenvironment. Thus, macropinocytosis is associated with cancer malignancy. Macropinocytic uptake can be induced in cancer cells by different stress stimuli, acting as an adaptive mechanism for the cells to resist stresses in the tumor milieu. Here, we review the cellular stresses that are known to promote macropinocytosis, as well as the underlying molecular mechanisms that drive this process.

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  1. Cell and Molecular Biology of Cancer Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA

    Guillem Lambies & Cosimo Commisso

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  2. Cosimo Commisso
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  1. Cell and Molecular Biology of Cancer Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA

    Cosimo Commisso

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Lambies, G., Commisso, C. (2022). Macropinocytosis and Cancer: From Tumor Stress to Signaling Pathways. In: Commisso, C. (eds) Macropinocytosis. Subcellular Biochemistry, vol 98. Springer, Cham. https://doi.org/10.1007/978-3-030-94004-1_2

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