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Obstructive Sleep Apnea: Clinical Epidemiology and Presenting Manifestations

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Essentials of Sleep Medicine

Part of the book series: Respiratory Medicine ((RM))

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Abstract

Obstructive sleep apnea (OSA) is found at all stages of life, in all races, and with all shapes and sizes of people, and can rise to the level of a disorder (OSAHS). Early detection of it improves waketime sleepiness and inattention, quality of life, and a reduction in medical costs. The questions being addressed are how OSA conditions affect morbidity and interact with chronic medical conditions. OSA is a complex disease in which no one feature or genetic set point or biological marker alone sets it apart as a diagnosis. Risk factors and complaints are not causal. It is sleep that precipitates disordered breathing, and added to it are the tendency for the upper airway to close, ventilatory instability with sleep and its stages, and the degree of upper airway muscle activation in sleep or in response to upper airway closure. Besides summarizing the population prevalence of OSA, the chapter examines presentations and recognition of OSA in pathways for several non-sleep outpatient and inpatient populations and considers whether ascertainment or preventative measures to manage OSA might be helpful. The chapter will introduce the epidemiologic data in each setting rather than review all datasets in a disorder in which OSA may contribute to its pathophysiology.

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References

  1. Aboussouan LS, Mireles-Cabodevila E. Sleep-disordered breathing in neuromuscular disease: diagnostic and therapeutic challenges. Chest. 2017;152:880–92.

    Article  PubMed  Google Scholar 

  2. Alattar M, Harring JJ, Mitchell M, Sloane P. Sleep problems in primary care: a North Carolina family practice research network (NC-FP-RN) study. J Am Board Fam Med. 2007;20:365–74.

    Article  PubMed  Google Scholar 

  3. Albdewi MA, Liistro G, El Tahry R. Sleep-disordered breathing in patients with neuromuscular disease. Sleep Breathing = Schlaf Atmung. 2018;22:277–86.

    Article  PubMed  Google Scholar 

  4. Benjafield AV, Ayas NT, Eastwood PR, Heinzer R, Ip MSM, Morrell MJ, Nunez CM, Patel SR, Penzel T, Pépin JL, Peppard PE, Sinha S, Tufik S, Valentine K, Malhotra A. Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med. 2019;7:687–98.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Bishop TM, Ashrafioun L, Pigeon WR. The association between sleep apnea and suicidal thought and behavior: an analysis of National Survey Data. J Clin Psychiatry. 2018;79:17m11480.

    Article  PubMed  Google Scholar 

  6. Cai A, Zhou Y, Zhang J, Zhong Q, Wang R, Wang L. Epidemiological characteristics and gender-specific differences of obstructive sleep apnea in a Chinese hypertensive population: a cross-sectional study. BMC Cardiovasc Disord. 2017;17:8.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Ceccato F, Bernkopf E, Scaroni C. Sleep apnea syndrome in endocrine clinics. J Endocrinol Investig. 2015;38:827–34.

    Article  CAS  Google Scholar 

  8. Chiodo AE, Sitrin RG, Bauman KA. Sleep disordered breathing in spinal cord injury: a systematic review. J Spinal Cord Med. 2016;39:374–82.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Chuang LP, Hsu SC, Lin SW, Ko WS, Chen NH, Tsai YH. Prevalence of snoring and witnessed apnea in Taiwanese adults. Chang Gung Med J. 2008;31:175–81.

    PubMed  Google Scholar 

  10. Chung F, Abdullah HR, Liao P. STOP-Bang questionnaire: a practical approach to screen for obstructive sleep apnea. Chest. 2016;149:631–8.

    Article  PubMed  Google Scholar 

  11. Cristescu Teodor R, Mihaltan FD. Eyelid laxity and sleep apnea syndrome: a review. Romanian J Ophthalmol. 2019;63:2–9.

    Article  Google Scholar 

  12. Crummy F, Piper AJ, Naughton MT. Obesity and the lung: 2. Obesity and sleep-disordered breathing. Thorax. 2008;63:738–46.

    Article  CAS  PubMed  Google Scholar 

  13. Du W, Liu J, Zhou J, Ye D, OuYang Y, Deng Q. Obstructive sleep apnea, COPD, the overlap syndrome, and mortality: results from the 2005-2008 National Health and Nutrition Examination Survey. Int J Chron Obstruct Pulmon Dis. 2018;13:665–74.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Facco FL, Parker CB, Reddy UM, Silver RM, Koch MA, Louis JM, Basner RC, Chung JH, Nhan-Chang CL, Pien GW, Redline S, Grobman WA, Wing DA, Simhan HN, Haas DM, Mercer BM, Parry S, Mobley D, Hunter S, Saade GR, Schubert FP, Zee PC. Association between sleep-disordered breathing and hypertensive disorders of pregnancy and gestational diabetes mellitus. Obstet Gynecol. 2017;129:31–41.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Fietze I, Laharnar N, Obst A, Ewert R, Felix SB, Garcia C, Gläser S, Glos M, Schmidt CO, Stubbe B, Völzke H, Zimmermann S, Penzel T. Prevalence and association analysis of obstructive sleep apnea with gender and age differences – results of SHIP-trend. J Sleep Res. 2019;28:e12770.

    Article  PubMed  Google Scholar 

  16. Heinzer R, Vat S, Marques-Vidal P, Marti-Soler H, Andries D, Tobback N, Mooser V, Preisig M, Malhotra A, Waeber G, Vollenweider P, Tafti M, Haba-Rubio J. Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study. Lancet Respir Med. 2015;3:310–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Huang T, Lin BM, Redline S, Curhan GC, Hu FB, Tworoger SS. Type of menopause, age at menopause, and risk of developing obstructive sleep apnea in postmenopausal women. Am J Epidemiol. 2018;187:1370–9.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Jaimchariyatam N, Na-Rungsri K, Tungsanga S, Lertmaharit S, Lohsoonthorn V, Totienchai S. Obstructive sleep apnea as a risk factor for preeclampsia-eclampsia. Sleep Breathing = Schlaf Atmung. 2019;23:687–93.

    Article  PubMed  Google Scholar 

  19. Jonas DE, Amick HR, Feltner C, Weber RP, Arvanitis M, Stine A, Lux L, Middleton JC, Voisin C, Harris RP. U.S. preventive services task force evidence syntheses, formerly systematic evidence reviews. In: Screening for obstructive sleep apnea in adults: an evidence review for the US preventive services task force. Rockville: Agency for Healthcare Research and Quality (US); 2017.

    Chapter  Google Scholar 

  20. Loube DI, Gay PC, Strohl KP, Pack AI, White DP, Collop NA. Indications for positive airway pressure treatment of adult obstructive sleep apnea patients: a consensus statement. Chest. 1999;115:863–6.

    Article  CAS  PubMed  Google Scholar 

  21. Louis JM, Koch MA, Reddy UM, Silver RM, Parker CB, Facco FL, Redline S, Nhan-Chang CL, Chung JH, Pien GW, Basner RC, Grobman WA, Wing DA, Simhan HN, Haas DM, Mercer BM, Parry S, Mobley D, Carper B, Saade GR, Schubert FP, Zee PC. Predictors of sleep-disordered breathing in pregnancy. Am J Obstet Gynecol. 2018;218:521.e521–12.

    Article  Google Scholar 

  22. Lyons MM, Keenan BT, Li J, Khan T, Elkassabany N, Walsh CM, Williams NN, Pack AI, Gurubhagavatula I. Symptomless multi-variable apnea prediction index assesses obstructive sleep apnea risk and adverse outcomes in elective surgery. Sleep. 2017;40:zsw081.

    Article  PubMed Central  Google Scholar 

  23. Lyons MM, Kraemer JF, Dhingra R, Keenan BT, Wessel N, Glos M, Penzel T, Gurubhagavatula I. Screening for obstructive sleep apnea in commercial drivers using EKG-derived respiratory power index. J Clin Sleep Med. 2019;15:23–32.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Masa JF, Pépin JL, Borel JC, Mokhlesi B, Murphy PB, Sánchez-Quiroga M. Obesity hypoventilation syndrome. Eur Respir Rev. 2019;28:180097.

    Article  PubMed  Google Scholar 

  25. Nair R, Radhakrishnan K, Chatterjee A, Gorthi SP, Prabhu VA. Sleep apnea-predictor of functional outcome in acute ischemic stroke. J Stroke Cerebrovasc Dis. 2019;28:807–14.

    Article  PubMed  Google Scholar 

  26. Namen AM, Chatterjee A, Huang KE, Feldman SR, Haponik EF. Recognition of sleep apnea is increasing. Analysis of trends in two large, representative databases of outpatient practice. Ann Am Thorac Soc. 2016;13:2027–34.

    Article  PubMed  Google Scholar 

  27. Netzer NC, Hoegel JJ, Loube D, Netzer CM, Hay B, Alvarez-Sala R, Strohl KP. Prevalence of symptoms and risk of sleep apnea in primary care. Chest. 2003;124:1406–14.

    Article  PubMed  Google Scholar 

  28. Netzer NC, Stoohs RA, Netzer CM, Clark K, Strohl KP. Using the Berlin questionnaire to identify patients at risk for the sleep apnea syndrome. Ann Intern Med. 1999;131:485–91.

    Article  CAS  PubMed  Google Scholar 

  29. Nieto FJ, Young TB, Lind BK, Shahar E, Samet JM, Redline S, D'Agostino RB, Newman AB, Lebowitz MD, Pickering TG. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA. 2000;283:1829–36.

    Article  CAS  PubMed  Google Scholar 

  30. Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol. 2013;177:1006–14.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Peppard PE, Young T, Palta M, Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med. 2000;342:1378–84.

    Article  CAS  PubMed  Google Scholar 

  32. Plante DT, Epstein LJ, Fields BG, Shelgikar AV, Rosen IM. Competency-based sleep medicine fellowships: addressing workforce needs and enhancing educational quality. J Clin Sleep Med. 2020;16:137–41.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Qaseem A, Holty JE, Owens DK, Dallas P, Starkey M, Shekelle P. Management of obstructive sleep apnea in adults: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2013;159:471–83.

    Article  PubMed  Google Scholar 

  34. Rod NH, Kjeldgård L, Åkerstedt T, Ferrie JE, Salo P, Vahtera J, Alexanderson K. Sleep apnea, disability pensions, and cause-specific mortality: a Swedish Nationwide Register Linkage Study. Am J Epidemiol. 2017;186:709–18.

    Article  PubMed  Google Scholar 

  35. Santos M, Hofmann RJ. Ocular manifestations of obstructive sleep apnea. J Clin Sleep Med. 2017;13:1345–8.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Schwab RJ, Badr SM, Epstein LJ, Gay PC, Gozal D, Kohler M, Levy P, Malhotra A, Phillips BA, Rosen IM, Strohl KP, Strollo PJ, Weaver EM, Weaver TE. An official American Thoracic Society statement: continuous positive airway pressure adherence tracking systems. The optimal monitoring strategies and outcome measures in adults. Am J Respir Crit Care Med. 2013;188:613–20.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Shahar E, Whitney CW, Redline S, Lee ET, Newman AB, Nieto FJ, O'Connor GT, Boland LL, Schwartz JE, Samet JM. Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. Am Rev Respir Crit Care Med. 2001;163:19–25.

    Article  CAS  Google Scholar 

  38. Stoohs RA, Barger K, Dement WC. Sleep disordered breathing in primary care medicine. Sleep Breathing = Schlaf Atmung. 1997;2:11–22.

    CAS  PubMed  Google Scholar 

  39. Strohl KP. Diabetes and sleep apnea. Sleep. 1996;19(10 Suppl):S225–8.

    Article  CAS  PubMed  Google Scholar 

  40. Strohl KP, Butler JP, Malhotra A. Mechanical properties of the upper airway. Compr Physiol. 2012;2(3):1853–72.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Strohl KP, Cherniack NS, Gothe B. Physiologic basis of therapy for sleep apnea. Am Rev Respir Dis. 1986;134:791–802.

    CAS  PubMed  Google Scholar 

  42. Sunwoo JS, Hwangbo Y, Kim WJ, Chu MK, Yun CH, Yang KI. Prevalence, sleep characteristics, and comorbidities in a population at high risk for obstructive sleep apnea: a nationwide questionnaire study in South Korea. PLoS One. 2018;13:e0193549.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Teodorescu M, Barnet JH, Hagen EW, Palta M, Young TB, Peppard PE. Association between asthma and risk of developing obstructive sleep apnea. JAMA. 2015;313:156–64.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Tishler PV, Larkin EK, Schluchter MD, Redline S. Incidence of sleep-disordered breathing in an urban adult population: the relative importance of risk factors in the development of sleep didordered breathing. JAMA. 2003;289:2230–7.

    Article  PubMed  Google Scholar 

  45. Watson NF, Rosen IM, Chervin RD. The past is prologue: the future of sleep medicine. J Clin Sleep Med. 2017;13:127–35.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Wellman A, Edwards BA, Sands SA, Owens RL, Nemati S, Butler J, Passaglia CL, Jackson AC, Malhotra A, White DP. A simplified method for determining phenotypic traits in patients with obstructive sleep apnea. J Appl Physiol. 1985;114:911–22, 2013.

    Article  CAS  Google Scholar 

  47. Whyte KF, Allen MB, Fitzpatrick MF, Douglas NJ. Accuracy and significance of scoring hypopneas. Sleep. 1992;15:257–60.

    Article  CAS  PubMed  Google Scholar 

  48. Yasin R, Muntham D, Chirakalwasan N. Uncovering the sleep disorders among young doctors. Sleep Breathing = Schlaf Atmung. 2016;20:1137–44.

    Article  PubMed  Google Scholar 

  49. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Bader S. The occurrence of sleep disordered breathing in middle-aged adults. New Engl J Med. 1993;328:1230–5.

    Article  CAS  PubMed  Google Scholar 

  50. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. 1993;328:1230–5.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Kingman P. Strohl .

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Yeh, E., Chaudhary, N., Strohl, K.P. (2022). Obstructive Sleep Apnea: Clinical Epidemiology and Presenting Manifestations. In: Badr, M.S., Martin, J.L. (eds) Essentials of Sleep Medicine. Respiratory Medicine. Humana, Cham. https://doi.org/10.1007/978-3-030-93739-3_5

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  • DOI: https://doi.org/10.1007/978-3-030-93739-3_5

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