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A Young Man with Clubbed Fingers and Toes

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Part of the Clinical Cases in Dermatology book series (CLIDADE)


Pachydermoperiostosis is a rare genetic disease, related to the mutation of HPGD gene and SLCO2A1 gene, which lead to the catabolism anomalies of the prostaglandin E2 (PGE2). Pachydermoperiostosis is more likely to occur in male, characterized as pachyderma, clubbed fingers, and periostosis. Other common clinical manifestation includes seborrhea, blepharoptosis, hyperhidrosis and arthralgia. Diagnosis and differential diagnosis depend mainly on clinical manifestation, laboratory examination and radiological findings. There is no good treatment, mainly to perform symptomatic therapy. Oral non-steroidal anti-inflammatory drugs (NSAIDs) such as etoricoxib, is proved to be effective. Cosmetic surgery or injection of botulinum toxin type-A(BTX-A) is effective in improving facial appearence.


  • Pachydermoperiostosis
  • Gene mutation
  • PGE2
  • Clinical manifestation
  • Differential diagnosis
  • Treatment

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  • DOI: 10.1007/978-3-030-93666-2_18
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  1. Li Z, Yang Q, Yang Y, et al. Successful treatment of pachydermoperiostosis with etoricoxib in a patient with a homozygous splice-site mutation in the SLCO2A1 gene. Br J Dermatol. 2019;180:682–4.

    CAS  CrossRef  Google Scholar 

  2. Xiang W, Yong L, Hamblin Michael R, et al. Facial manifestations of Pachydermoperiostosis treated with botulinum toxin type-a: report of 3 cases. Acta Derm Venereol. 2017;97:761–2.

    CrossRef  Google Scholar 

  3. Shan-Shan L, Jin-We H, Wen-Zhen F, et al. Clinical, biochemical, and genetic features of 41 Han Chinese families with primary hypertrophic osteoarthropathy, and their therapeutic response to etoricoxib: results from a six-month prospective clinical intervention. J Bone Miner Res. 2017;32:1659–66.

    CrossRef  Google Scholar 

  4. Souto Filho João TD, de Morais RA, Ribeiro Helena AA, et al. Paravertebral extramedullary haemopoiesis in a patient with pachydermoperiostosis. Br J Haematol. 2020;190:304.

    CrossRef  Google Scholar 

  5. Cassandra H, Natasa D, Ali Z, et al. Pachydermoperiostosis: the elephant skin disease. J Rheumatol. 2017;44:1680–1.

    CrossRef  Google Scholar 

  6. Pedro M, Maria S-B, David C, et al. Pachydermoperiostosis mimicking the acral abnormalities of acromegaly. Endocrine. 2020;67:499–500.

    CrossRef  Google Scholar 

  7. Cai-Yue L, Ying-Fan Z. Images in clinical medicine. Pachydermoperiostosis. N Engl J Med. 1930;2014:370.

    Google Scholar 

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Zhang, M., Guo, H., Zheng, S., Gao, XH., Li, JH., Lin, ZT. (2022). A Young Man with Clubbed Fingers and Toes. In: Satolli, F., Tirant, M., Wollina, U., Lotti, T.M. (eds) Clinical Cases in Pediatric Skin Cancers. Clinical Cases in Dermatology. Springer, Cham.

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-93665-5

  • Online ISBN: 978-3-030-93666-2

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