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Clinical Cases in Pediatric Skin Cancers pp 53–56Cite as

A Newborn Girl with Blisters

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Part of the Clinical Cases in Dermatology book series (CLIDADE)

Abstract

Incontinentia pigmenti is caused by a mutation in NEMO/IKKγ gene which locates on X chromosome, which is lethal for male fetuses. It involves skin, teeth, hair or neurologic system. The cutaneous lesions distribute on the extremities along Blaschko’s lines, which usually occur in sequelae including vesicular, verrucous, hyperpigmented and atrophic stages. The vesicles usually are found at birth or within a few weeks of life and resolve spontaneously in a few days to weeks. The diagnosis is relatively easy if the the baby present with typical skin manifestations. The data of a female relative with confirmed incontinentia pigmenti or a gene defect of NEMO has a significant role for the diagnosis. Here we report a case of incontinentia pigmenti in a neonate girl with blisters.

Keywords

  • Incontinentia pigmenti
  • NEMO
  • Inhibitor kappa kinase
  • IKK

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Fig. 12.1
Fig. 12.2

References

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Author information

Authors and Affiliations

  1. Department of Dermatology, The First Hospital of China Medical University, Shenyang, China

    Hong-Hui Xu & Xing-Hua Gao

Authors
  1. Hong-Hui Xu
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  2. Xing-Hua Gao
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Editor information

Editors and Affiliations

  1. Dermatologic Unit, University Hospital of Parma, Parma, Italy

    Francesca Satolli

  2. Dermatology, Hanoi Medical University, Hanoi, Vietnam

    Prof. Michael Tirant

  3. Dermatologie & Allergologie, Städtisches Klinikum Dresden, Dresden, Germany

    Uwe Wollina

  4. Science of Communication, Marconi University, Rome, Roma, Italy

    Torello M. Lotti

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Xu, HH., Gao, XH. (2022). A Newborn Girl with Blisters. In: Satolli, F., Tirant, M., Wollina, U., Lotti, T.M. (eds) Clinical Cases in Pediatric Skin Cancers. Clinical Cases in Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-030-93666-2_12

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  • DOI: https://doi.org/10.1007/978-3-030-93666-2_12

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-93665-5

  • Online ISBN: 978-3-030-93666-2

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