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A Newborn Girl with Blisters

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Clinical Cases in Pediatric Skin Cancers

Part of the book series: Clinical Cases in Dermatology ((CLIDADE))

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Abstract

Incontinentia pigmenti is caused by a mutation in NEMO/IKKγ gene which locates on X chromosome, which is lethal for male fetuses. It involves skin, teeth, hair or neurologic system. The cutaneous lesions distribute on the extremities along Blaschko’s lines, which usually occur in sequelae including vesicular, verrucous, hyperpigmented and atrophic stages. The vesicles usually are found at birth or within a few weeks of life and resolve spontaneously in a few days to weeks. The diagnosis is relatively easy if the the baby present with typical skin manifestations. The data of a female relative with confirmed incontinentia pigmenti or a gene defect of NEMO has a significant role for the diagnosis. Here we report a case of incontinentia pigmenti in a neonate girl with blisters.

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References

  1. Legarda-Addison D, et al. NEMO/IKK- gamma regulates an early NF-kappaB-independent cell-death check- point during TNF signaling. Cell Death Differ. 2009;16(9):1279–88.

    Article  CAS  Google Scholar 

  2. Kenwrick S, et al. Survival of male patients with incontinentia pigmenti carrying a lethal mutation can be explained by somatic mosaicism or Klinefelter syndrome. Am J Hum Genet. 2001;69(6):1210–027.

    Article  CAS  Google Scholar 

  3. Minić S, et al. Incontinentia pigmenti diagnostic criteria update. Clin Genet. 2014;85(6):536–42.

    Article  Google Scholar 

  4. Dogbevia GK, et al. Gene therapy decreases seizures in a model of Incontinentia pigmenti. Ann Neurol. 2017;82(1):93–104.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Dermatology, The First Hospital of China Medical University, Shenyang, China

    Hong-Hui Xu & Xing-Hua Gao

Authors
  1. Hong-Hui Xu
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  2. Xing-Hua Gao
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Editor information

Editors and Affiliations

  1. Dermatologic Unit, University Hospital of Parma, Parma, Italy

    Francesca Satolli

  2. Dermatology, Hanoi Medical University, Hanoi, Vietnam

    Michael Tirant

  3. Dermatologie & Allergologie, Städtisches Klinikum Dresden, Dresden, Germany

    Uwe Wollina

  4. Science of Communication, Marconi University, Rome, Roma, Italy

    Torello M. Lotti

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© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG

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Xu, HH., Gao, XH. (2022). A Newborn Girl with Blisters. In: Satolli, F., Tirant, M., Wollina, U., Lotti, T.M. (eds) Clinical Cases in Pediatric Skin Cancers. Clinical Cases in Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-030-93666-2_12

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  • DOI: https://doi.org/10.1007/978-3-030-93666-2_12

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-93665-5

  • Online ISBN: 978-3-030-93666-2

  • eBook Packages: MedicineMedicine (R0)

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