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Biomarkers, Between Diagnosis and Prognosis

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Key Topics in Perinatal Mental Health

Abstract

Perinatal depression is a heterogeneous disorder with differences in depression timing onset, symptomology, severity and treatment efficacy. The early individuation of mental health disease in women is mandatory to prevent a long duration of untreated illness, long-term consequences on offspring and maternal health effects in terms of mortality and morbidity.

Different biomarkers have been linked to perinatal depression, however no definitive conclusions can be done due to several variables involved in psychiatric disorder onset but also to the different methodological methods used in the studies.

The aim of this chapter is to outline the actual state of the art on biomarkers in perinatal depression, although being not comprehensive of all available data in literature, in order to search for reliable biomarkers able to early detect it and prevent its consequences on newborns.

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References

  1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders (DSM-5®). American Psychiatric Pub; 2013.

    Book  Google Scholar 

  2. Lapato DM, Roberson-Nay R, Kirkpatrick RM, et al. DNA methylation associated with postpartum depressive symptoms overlaps findings from a genome-wide association meta-analysis of depression. Clin Epigenetics. 2019;11(1):169.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Figueiredo FP, Parada AP, de Araujo LF, et al. The influence of genetic factors on peripartum depression: a systematic review. J Affect Disord. 2015;172:265–73.

    Article  PubMed  Google Scholar 

  4. Woody CA, Ferrari AJ, Siskind DJ, et al. A systematic review and meta-regression of the prevalence and incidence of PD. J Affect Disord. 2017;219:86–92.

    Article  CAS  PubMed  Google Scholar 

  5. Meltzer-Brody S, Howard LM, Bergink V, et al. Postpartum psychiatric disorders. Nat Rev Dis Primers. 2018;4:18022.

    Article  PubMed  Google Scholar 

  6. Peñalver Bernabé B, Maki PM, Dowty SM, et al. Precision medicine in PD in light of the human microbiome. Psychopharmacology. 2020;237(4):915–41.

    Article  PubMed  CAS  Google Scholar 

  7. Dagher RK, Bruckheim HE, Colpe LJ, et al. PD: Challenges and opportunities. J Womens Health (Larchmt). 2021;30(2):154–9.

    Article  Google Scholar 

  8. Galea LAM, Frokjaer VG. PD: Embracing variability toward better treatment and outcomes. Neuron. 2019;102(1):13–6.

    Article  CAS  PubMed  Google Scholar 

  9. Serati M, Buoli M, Altamura AC. Factors that affect duration of untreated illness in pregnant women with bipolar disorder. Am J Obstet Gynecol. 2015;213(6):876.

    Article  PubMed  Google Scholar 

  10. Barkin JL, Osborne LM, Buoli M, et al. Training frontline providers in the detection and management of perinatal mood and anxiety disorders. J Womens Health (Larchmt). 2020;29(7):889–90.

    Article  PubMed Central  Google Scholar 

  11. Grigoriadis S, VonderPorten EH, Mamisashvili L, et al. The impact of maternal depression during pregnancy on perinatal outcomes: a systematic review and meta-analysis. J Clin Psychiatry. 2013;74(4):e321–41.

    Article  PubMed  Google Scholar 

  12. Buoli M, Grassi S, Di Paolo M, et al. Is perinatal major depression affecting obstetrical outcomes? Commentary on “Impact of maternal depression on perinatal outcome in hospitalized women-a prospective study”. Arch Womens Ment Health. 2019;23(4):595–6.

    Article  PubMed  Google Scholar 

  13. Serati M, Bertino V, Malerba MR, et al. Obstetric complications and subsequent risk of mood disorders for offspring in adulthood: a comprehensive overview. Nord J Psychiatry. 2020;1–9.

    Google Scholar 

  14. Schlotz W, Phillips DI. Fetal origins of mental health: evidence and mechanisms. Brain Behav Immun. 2009;23(7):905–16.

    Article  PubMed  Google Scholar 

  15. Howard LM, Piot P, Stein A. No health without perinatal mental health. Lancet. 2014;384(9956):1723–4.

    Article  PubMed  Google Scholar 

  16. Plant DT, Pariante CM, Sharp D, Pawlby S. Maternal depression during pregnancy and offspring depression in adulthood: role of child maltreatment. Br J Psychiatry. 2015;207(3):213–20.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Viuff AC, Sharp GC, Rai D, et al. Maternal depression during pregnancy and cord blood DNA methylation: findings from the Avon Longitudinal Study of Parents and Children. Transl Psychiatry. 2018;8:244.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Goodman JH. PD and infant mental health. Arch Psychiatr Nurs. 2019;33(3):217–24.

    Article  PubMed  Google Scholar 

  19. World Health Organization. Maternal mental health and child health and development in low and middle income countries: report of the meeting, Geneva, Switzerland, 30 January–1 February, 2008.

    Google Scholar 

  20. Curry SJ, Krist AH, Owens DK, et al. US Preventive Services Task Force Interventions to Prevent PD: US Preventive Services Task Force Recommendation Statement. JAMA. 2019;321(6):580–7.

    Article  PubMed  Google Scholar 

  21. Goldstein Z, Rosen B, Howlett A, et al. Interventions for paternal PD: a systematic review. J Affect Disord. 2020;265:505–10.

    Article  PubMed  Google Scholar 

  22. Bruno A, Celebre L, Mento C, et al. When fathers begin to Falter: a comprehensive review on paternal PD. Int J Environ Res Public Health. 2020;17(4):1139.

    Article  PubMed Central  Google Scholar 

  23. Serati M, Redaelli M, Buoli M, Altamura AC. Perinatal major depression biomarkers: a systematic review. J Affect Disord. 2016;193:391–404.

    Article  CAS  PubMed  Google Scholar 

  24. Konstantinou G, Spyropoulou A, Zervas I. Immune-inflammatory and autoimmune mechanisms in postpartum depression. Psychiatriki. 2020;31(1):47–56. Greek, Modern

    Article  PubMed  Google Scholar 

  25. Strimbu K, Tavel JA. What are biomarkers? Curr Opin HIV AIDS. 2010;5(6):463–6.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Aronson JK, Ferner RE. Biomarkers: a general review. Curr Protoc Pharmacol. 2017;76:9.23.1–9.23.17.

    Google Scholar 

  27. Gururajan A, Clarke G, Dinan TG, Cryan JF. Molecular biomarkers of depression. Neurosci Biobehav Rev. 2016;64:101–33.

    Article  CAS  PubMed  Google Scholar 

  28. Guintivano J, Manuck T, Meltzer-Brody S. Predictors of postpartum depression: a comprehensive review of the last decade of evidence. Clin Obstet Gynecol. 2018;61(3):591–603.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Šebela A, Hanka J, Mohr P. Etiology, risk factors, and methods of postpartum depression prevention. Ceska Gynekol. 2018;83(6):468–73.

    PubMed  Google Scholar 

  30. Šebela A, Hanka J, Mohr P. Diagnostics and modern trends in therapy of postpartum depression. Ceska Gynekol. 2019;84(1):68–72.

    PubMed  Google Scholar 

  31. Bloch M, Daly RC, Rubinow DR. Endocrine factors in the etiology of postpartum depression. Compr Psychiatry. 2003;44(3):234–46.

    Article  PubMed  Google Scholar 

  32. Guintivano J, Arad M, Gould TD, et al. Antenatal prediction of postpartum depression with blood DNA methylation biomarkers. Mol Psychiatry. 2014;19(5):560–7.

    Article  CAS  PubMed  Google Scholar 

  33. Pinsonneault JK, Sullivan D, Sadee W, et al. Association study of the estrogen receptor gene ESR1 with postpartum depression—a pilot study. Arch Womens Ment Health. 2013;16(6):499–509.

    Article  PubMed  Google Scholar 

  34. McEvoy K, Payne JL, Osborne LM. Neuroactive steroids and PD: a review of recent literature. Curr Psychiatry Rep. 2018;20(9):78.

    Article  PubMed  PubMed Central  Google Scholar 

  35. O'Connor TG, Tang W, Gilchrist MA, et al. Diurnal cortisol patterns and psychiatric symptoms in pregnancy: short-term longitudinal study. Biol Psychol. 2014;96:35–41.

    Article  PubMed  Google Scholar 

  36. Glynn LM, Davis EP, Sandman CA. New insights into the role of perinatal HPA-axis dysregulation in postpartum depression. Neuropeptides. 2013;47(6):363–70.

    Article  CAS  PubMed  Google Scholar 

  37. Ferguson EH, Di Florio A, Pearson B, et al. HPA axis reactivity to pharmacologic and psychological stressors in euthymic women with histories of postpartum versus major depression. Arch Womens Ment Health. 2017;20(3):411–20.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Zaconeta AM, Amato AA, Motta LD, Casulari LA. Relationship between placental corticotropin-releasing hormone and postpartum depression: can defining what “postpartum depression” means make a difference? Psychosom Med. 2015;77(3):342.

    Article  PubMed  Google Scholar 

  39. Parcells DA. Women's mental health nursing: depression, anxiety and stress during pregnancy. J Psychiatr Ment Health Nurs. 2010;17(9):813–20.

    Article  CAS  PubMed  Google Scholar 

  40. Buss C, Davis EP, Shahbaba B, Pruessner JC, Head K, Sandman CA. Maternal cortisol over the course of pregnancy and subsequent child amygdala and hippocampus volumes and affective problems. Proc Natl Acad Sci U S A. 2012;109(20):E1312–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Buss C, Entringer S, Wadhwa PD. Fetal programming of brain development: intrauterine stress and susceptibility to psychopathology. Sci Signal. 2012a;5(245):pt7.

    Article  PubMed  CAS  Google Scholar 

  42. Bergink V, Gibney SM, Drexhage HA. Autoimmunity, inflammation, and psychosis: a search for peripheral markers. Biol Psychiatry. 2014;75(4):324–31.

    Article  CAS  PubMed  Google Scholar 

  43. Apter-Levy Y, Zagoory-Sharon O, Feldman R. Chronic depression alters mothers' DHEA and DEHA-to-cortisol ratio: implications for maternal behavior and child outcomes. Front Psychiatry. 2020;11:728.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Sundström Poromaa I, Comasco E, Georgakis MK, Skalkidou A. Sex differences in depression during pregnancy and the postpartum period. J Neurosci Res. 2017;95(1–2):719–30.

    Article  PubMed  CAS  Google Scholar 

  45. Osborne S, Biaggi A, Chua TE, et al. Antenatal depression programs cortisol stress reactivity in offspring through increased maternal inflammation and cortisol in pregnancy: The Psychiatry Research and Motherhood-Depression (PRAM-D) Study. Psychoneuroendocrinology. 2018;98:211–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Figueira P, Malloy-Diniz L, Campos SB, et al. An association study between the Val66Met polymorphism of the BDNF gene and postpartum depression. Arch Womens Ment Health. 2010;13(3):285–9.

    Article  PubMed  Google Scholar 

  47. Comasco E, Sylvén SM, Papadopoulos FC, et al. Postpartum depressive symptoms and the BDNFVal66Met functional polymorphism: effect of season of delivery. Arch Womens Ment Health. 2011;14(6):453–63.

    Article  PubMed  Google Scholar 

  48. Lommatzsch M, Hornych K, Zingler C, et al. Maternal serum concentrations of BDNF and depression in the perinatal period. Psychoneuroendocrinology. 2006;31(3):388–94.

    Article  CAS  PubMed  Google Scholar 

  49. Pinheiro RT, Pinheiro KA, daCunha Coelho FM, et al. Brain derived neurotrophic factor levels in women with postpartum affective disorder and suicidality. Neurochem Res. 2010;37(10):2229–34.

    Article  CAS  Google Scholar 

  50. Fung J, Gelaye B, Zhong QY, et al. Association of decreased serum brain-derived neurotrophic factor (BDNF) concentrations in early pregnancy with antepartum depression. BMC Psychiatry. 2015;15(1):43.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  51. Mandolini GM, Lazzaretti M, Delvecchio G, et al. Association between serum BDNF levels and maternal PD: A review: special section on “Translational and Neuroscience Studies in Affective Disorders”. J Affect Disord. 2020;261:271–6. (Maria Nobile MD, PhD)

    Article  CAS  PubMed  Google Scholar 

  52. Horowitz MA, Zunszain PA. Neuroimmune and neuroendocrine abnormalities in depression: two sides of the same coin. Ann N Y Acad Sci. 2015;1351:68–79.

    Article  CAS  PubMed  Google Scholar 

  53. Leff-Gelman P, Mancilla-Herrera I, Flores-Ramos M, et al. The immune system and the role of inflammation in PD. Neurosci Bull. 2016;32(4):398–420.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. Simpson W, Steiner M, Coote M, Frey BN. Relationship between inflammatory biomarkers and depressive symptoms during late pregnancy and the early postpartum period: a longitudinal study. Braz J Psychiatry. 2016;38(3):190–6.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Miller ES, Hoxha D, Pinheiro E, et al. The association of serum C-reactive protein with the occurrence and course of postpartum depression. Arch Womens Ment Health. 2019;22(1):129–32.

    Article  PubMed  Google Scholar 

  56. Cassidy-Bushrow AE, Peters RM, Johnson DA, Templin TN. Association of depressive symptoms with inflammatory biomarkers among pregnant African–American women. J Reprod Immunol. 2012;94(2):202–9.

    Article  CAS  PubMed  Google Scholar 

  57. Azar R, Mercer D. Mild depressive symptoms are associated with elevated C-reactive protein and proinflammatory cytokine levels during early to mid- gestation: a prospective pilot study. J Womens Health (Larchmt). 2013;22(4):385–9.

    Article  Google Scholar 

  58. Buglione-Corbett R, Deligiannidis KM, Leung K, et al. Expression of inflammatory markers in women with perinatal depressive symptoms. Arch Womens Ment Health. 2018;21(6):671–9.

    Article  CAS  PubMed  Google Scholar 

  59. Miller ES, Sakowicz A, Roy A, et al. Plasma and cerebrospinal fluid inflammatory cytokines in PD. Am J Obstet Gynecol. 2019;220(3):271.e1–271.e10.

    Article  CAS  Google Scholar 

  60. Bränn E, Edvinsson Å, Rostedt Punga A, et al. Inflammatory and anti-inflammatory markers in plasma: from late pregnancy to early postpartum. Sci Rep. 2019;9(1):1863.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  61. Bränn E, Papadopoulos F, Fransson E, et al. Inflammatory markers in late pregnancy in association with postpartum depression: a nested case-control study. Psychoneuroendocrinology. 2017;79:146–59.

    Article  PubMed  CAS  Google Scholar 

  62. Osborne LM, Gilden J, Kamperman AM, et al. T-cell defects and postpartum depression. Brain Behav Immun. 2020;87:397–403.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Cox EQ, Stuebe A, Pearson B, et al. Oxytocin and HPA stress axis reactivity in postpartum women. Psychoneuroendocrinology. 2015;55:164–72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  64. Moura D, Canavarro MC, Figueiredo-Braga M. Oxytocin and depression in the perinatal period-a systematic review. Arch Womens Ment Health. 2016;19(4):561–70.

    Article  PubMed  Google Scholar 

  65. Serati M, Grassi S, Redaelli M, et al. Is there an association between oxytocin levels in plasma and pregnant women’s mental health? J Am Psychiatr Nurses Assoc. 2021;27(3):222–30.

    Article  PubMed  Google Scholar 

  66. Skrundz M, Bolten M, Nast I, et al. Plasma oxytocin concentration during pregnancy is associated with development of postpartum depression. Neuropsychopharmacology. 2011;36(9):1886–93.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Thul TA, Corwin EJ, Carlson NS, et al. Oxytocin and postpartum depression: a systematic review. Psychoneuroendocrinology. 2020;120:104793.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. Eyles DW, Smith S, Kinobe R, et al. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat. 2005;29(1):21–30.

    Article  CAS  PubMed  Google Scholar 

  69. Williams ME, Frey BN. Salivary cortisol during memory encoding in pregnancy predicts postpartum depressive symptoms: a longitudinal study. Trends Psychiatry Psychother. 2017;39(4):280–4.

    Article  PubMed  Google Scholar 

  70. Larqué E, Morales E, Leis R, Blanco-Carnero JE. Maternal and foetal health implications of vitamin D status during pregnancy. Ann Nutr Metab. 2018;72(3):179–92.

    Article  PubMed  CAS  Google Scholar 

  71. Cui X, Pertile R, Liu P, Eyles DW. Vitamin D regulates tyrosine hydroxylase expression: N-cadherin a possible mediator. Neuroscience. 2015;304:90–100.

    Article  CAS  PubMed  Google Scholar 

  72. Murphy PK, Mueller M, Hulsey TC, et al. An exploratory study of postpartum depression and vitamin D. J Am Psychiatr Nurses Assoc. 2010;16(3):170–7.

    Article  PubMed  Google Scholar 

  73. Cassidy-Bushrow AE, Peters RM, Johnson DA. Vitamin D nutritional status and antenatal depressive symptoms in African American women. J Womens Health (Larchmt). 2012;21:1189–95.

    Article  Google Scholar 

  74. Brandenbarg J, Vrijkotte T, Goedhart G, VanEijsden M. Maternal early- pregnancy vitamin status is associated with maternal depressive symptoms in the Amsterdam born children and their development Cohort. Psychosom Med. 2012;74:751–7.

    Article  CAS  PubMed  Google Scholar 

  75. Gur EB, Gokduman A, Turan GA, et al. Mid pregnancy vitamin D levels and postpartum depression. Eur J Obs Gynecol Reprod Biol. 2014;179:110–6.

    Article  CAS  Google Scholar 

  76. Robinson M, Whitehouse AJ, Newnham JP, et al. Low maternal serum vitamin during pregnancy and the risk for postpartum depression symptoms. Arch Womens Ment Health. 2014;17(3):213–9.

    Article  PubMed  Google Scholar 

  77. Miyake Y, Tanaka K, Okubo H, et al. Dietary vitamin D intake and prevalence of depressive symptoms during pregnancy in Japan. Nutrition. 2015;31(1):160–5.

    Article  CAS  PubMed  Google Scholar 

  78. Accortt EE, Schetter CD, Peters RM, Cassidy-Bushrow AE. Lower prenatal vitamin D status and postpartum depressive symptomatology in African American women: preliminary evidence for moderation by inflammatory cytokines. Arch Womens Ment Health. 2015:1–11.

    Google Scholar 

  79. Lamb AR, Lutenbacher M, Wallston KA, et al. Vitamin D deficiency and depressive symptoms in the perinatal period. Arch Womens Ment Health. 2018;21(6):745–55.

    Article  PubMed  Google Scholar 

  80. Sparling TM, Nesbitt RC, Henschke N, Gabrysch S. Nutrients and PD: a systematic review. J Nutr Sci. 2017;6:e61.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  81. Teofilo MM, Farias DR, Pinto Tde J, et al. HDL-cholesterol concentrations are inversely associated with Edinburgh Postnatal Depression Scale scores during pregnancy: results from a Brazilian cohort study. J Psychiatr Res. 2014;58:181–8.

    Article  PubMed  Google Scholar 

  82. Otto SJ, de Groot RH, Hornstra G. Increased risk of postpartum depressive symptoms is associated with slower normalization after pregnancy of the functional docosahexaenoic acid status. Prostaglandins Leukot Essent Fatty Acids. 2003;69(4):237–43.

    Article  CAS  PubMed  Google Scholar 

  83. Chang JP, Lin CY, Lin PY, et al. Polyunsaturated fatty acids and inflammatory markers in major depressive episodes during pregnancy. Prog Neuro-Psychopharmacol Biol Psychiatry. 2018;80(Pt C):273–8.

    Article  CAS  Google Scholar 

  84. Mozurkewich EL, Berman DR, Vahratian A, et al. Effect of prenatal EPA and DHA on maternal and umbilical cord blood cytokines. BMC Pregnancy Childbirth. 2018;18(1):261.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  85. Mocking RJT, Steijn K, Roos C, et al. Omega-3 fatty acid supplementation for PD: a meta-analysis. J Clin Psychiatry. 2020;81(5):19r13106.

    Article  PubMed  Google Scholar 

  86. Doornbos B, vanGoor SA, Dijck-Brouwer DA, et al. Supplementation of a low dose of DHA or DHAþAA does not prevent peripartum depressive symptoms in a small population based sample. Prog Neuro-Psychopharmacol Biol Psychiatry. 2009;33(1):49–52.

    Article  CAS  Google Scholar 

  87. Mozurkewich EL, Clinton CM, Chilimigras JL, et al. The mothers, Omega-3, and Mental Health Study: a double-blind, randomized controlled trial. Am J Obs Gynecol. 2013;208(4):313–9.

    Article  CAS  Google Scholar 

  88. De Giuseppe R, Roggi C, Cena H. N-3LC-PUFA supplementation: effects on infant and maternal outcomes. Eur J Nutr. 2014;53(5):1147–54.

    Article  PubMed  CAS  Google Scholar 

  89. Gene Cards. The Human Gene Database, 2020. https://www.genecards.org/.

  90. Buoli M, Serati M, Grassi S, et al. The role of clock genes in the etiology of major depressive disorder. J Affect Disord. 2018;234:351–7.

    Article  CAS  PubMed  Google Scholar 

  91. Buoli M, Grassi S, Iodice S, et al. The role of clock genes in perinatal depression: the light in the darkness. Acta Psychiatr Scand. 2019;140(4):382–4.

    Article  CAS  PubMed  Google Scholar 

  92. Li JZ, Bunney BG, Meng F, et al. Circadian patterns of gene expression in the human brain and disruption in major depressive disorder. Proc Natl Acad Sci U S A. 2013;110:9950–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  93. Tabano S, Caldiroli A, Terrasi A, et al. A miRNome analysis of drug-free manic psychotic bipolar patients versus healthy controls. Eur Arch Psychiatry Clin Neurosci. 2019;270(7):893–900.

    Article  PubMed  Google Scholar 

  94. Bierer LM, Bader HN, Daskalakis NP, et al. Intergenerational effects of maternal holocaust exposure on FKBP5 methylation. Am J Psychiatry. 2020;177(8):744–53.

    Article  PubMed  Google Scholar 

  95. King L, Robins S, Chen G, et al. Perinatal depression and DNA methylation of oxytocin-related genes: a study of mothers and their children. Horm Behav. 2017;96:84–94.

    Article  CAS  PubMed  Google Scholar 

  96. Feldman R, Weller A, Zagoory-Sharon O, Levine A. Evidence for a neuroendocrinological foundation of human affiliation: plasma oxytocin levels across pregnancy and the postpartum period predict mother-infant bonding. Psychol Sci. 2007;18:965–70.

    Article  PubMed  Google Scholar 

  97. Roy B, Yoshino Y, Allen L, et al. Exploiting circulating microRNAs as biomarkers in psychiatric disorders. Mol Diagn Ther. 2020;24(3):279–98.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  98. Carnevali GS, Buoli M. The role of epigenetics in PD: are there any candidate biomarkers? J Affect Disord. 2021;280(Pt B):57–67.

    Article  PubMed  Google Scholar 

  99. Stein A, Pearson RM, Goodman SH, et al. Effects of perinatal mental disorders on the fetus and child. Lancet. 2014;384(9956):1800–19.

    Article  PubMed  Google Scholar 

  100. Pariante CM. Depression during pregnancy: molecular regulations of mothers’ and children’s behaviour. Biochem Soc Trans. 2014;42(2):582–6.

    Article  CAS  PubMed  Google Scholar 

  101. Biaggi A, Conroy S, Pawlby S, Pariante CM. Identifying the women at risk of antenatal anxiety and depression: a systematic review. J Affect Disord. 2016;191:62–77.

    Article  PubMed  PubMed Central  Google Scholar 

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Serati, M., Buoli, M., Barkin, J.L. (2022). Biomarkers, Between Diagnosis and Prognosis. In: Percudani, M., Bramante, A., Brenna, V., Pariante, C. (eds) Key Topics in Perinatal Mental Health. Springer, Cham. https://doi.org/10.1007/978-3-030-91832-3_26

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