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Pregnancy-Associated Proteins as a Tool in the Therapy of Autoimmune Diseases and Alloimmune Disorders (Review)

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Science and Global Challenges of the 21st Century - Science and Technology (Perm Forum 2021)

Part of the book series: Lecture Notes in Networks and Systems ((LNNS,volume 342))

Abstract

From the point of view of reproductive immunology, pregnancy is the only physiological phenomenon in which the immune system, recognizing fetal alloantigens, implements a response in the form of systemic (central) and peripheral tolerance. The factors that induce central tolerance in pregnancy are proteins associated with pregnancy. Conceptually, the embryo is a semi-allogenic transplant. Presumably, only a few molecules regulate the immune tolerance of the mother - glycodelin, human chorionic gonadotropin (hCG), Pregnancy-specific β1-glycoprotein (PSG), and alpha-fetoprotein (AFP) can be included in this list. Significantly, these molecules have evolved to perform a range of biological functions, including immunosuppression. Logically, it is necessary to try to apply the evolutionary potential in the practice of therapy for autoimmune diseases and transplantation. In this review, we consider information about the mechanisms of protein’s action on immune tolerance, as well as options for their using as pharmacological drugs. Exactly clinical situations require suppression “point” of the immune response.

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Acknowledgments

The work was performed as part of the state assignment, state registration number: AAAA-A19–119112290007-7 (“IEGM UB RAS”) and the Russian Foundation for Basic Research № 19-29-04055.

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Authors and Affiliations

  1. Institute of Ecology and Genetics of Microorganisms Ural Branch, Russian Academy of Sciences, 614081, Perm, Russia

    S. A. Zamorina, K. Yu. Shardina & V. P. Timganova

  2. Perm State Medical University named after Academician “E.A. Wagner” Ministry of Health of Russia, 614000, Perm, Russia

    S. A. Zamorina, Y. N. Troynich, N. P. Loginova & Y. A. Charushina

Authors
  1. S. A. Zamorina
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  2. Y. N. Troynich
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  3. N. P. Loginova
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  4. Y. A. Charushina
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  5. K. Yu. Shardina
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  6. V. P. Timganova
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Editor information

Editors and Affiliations

  1. ISEG, Universidade de Lisboa, Lisbon, Portugal

    Alvaro Rocha

  2. Perm State University, Perm, Russia

    Ekaterina Isaeva

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Zamorina, S.A., Troynich, Y.N., Loginova, N.P., Charushina, Y.A., Shardina, K.Y., Timganova, V.P. (2022). Pregnancy-Associated Proteins as a Tool in the Therapy of Autoimmune Diseases and Alloimmune Disorders (Review). In: Rocha, A., Isaeva, E. (eds) Science and Global Challenges of the 21st Century - Science and Technology. Perm Forum 2021. Lecture Notes in Networks and Systems, vol 342. Springer, Cham. https://doi.org/10.1007/978-3-030-89477-1_38

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