Skip to main content

HEp-2 Cell Image Recognition with Transferable Cross-Dataset Synthetic Samples

  • Conference paper
  • First Online:
Computer Analysis of Images and Patterns (CAIP 2021)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 13052))

Included in the following conference series:

Abstract

The paper examines the possibilities of using synthetic HEp-2 cell images as a means of data augmentation. The common problem of biomedical datasets is the shortage of annotated samples required for the training of deep learning techniques. Traditional approaches based on image rotation and mirroring have their limitations, and alternative techniques based on generative adversarial networks (GANs) are currently being explored. Instead of looking solely at a single dataset or the creation of a recognition model with applicability for multiple datasets, this study focuses on the transferability of synthetic HEp-2 samples among publicly available datasets. The paper offers a workflow where the quality of synthetic samples is confirmed via an independent fine-tuned neural network. The subsequent combination of synthetic samples with original images outperforms traditional augmentation approaches and leads to state-of-the-art performance on both publicly available HEp-2 cell image datasets employed in this study.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 69.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 89.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Bajić, B., Majtner, T., Lindblad, J., Sladoje, N.: Generalised deep learning framework for HEp-2 cell recognition using local binary pattern maps. IET Image Proc. 14(6), 1201–1208 (2020)

    Article  Google Scholar 

  2. Bayramoglu, N., Kannala, J., Heikkilä, J.: Human epithelial type 2 cell classification with convolutional neural networks. In: 15th International Conference on Bioinformatics and Bioengineering, pp. 1–6. IEEE (2015)

    Google Scholar 

  3. Bowles, C., et al.: GAN augmentation: augmenting training data using generative adversarial networks. arXiv preprint arXiv:1810.10863 (2018)

  4. Cascio, D., Taormina, V., Cipolla, M., Bruno, S., Fauci, F., Raso, G.: A multi-process system for HEp-2 cells classification based on SVM. Pattern Recogn. Lett. 82, 56–63 (2016)

    Article  Google Scholar 

  5. Faraki, M., Harandi, M., Wiliem, A., Lovell, B.: Fisher tensors for classifying human epithelial cells. Pattern Recogn. 47(7), 2348–2359 (2014)

    Article  Google Scholar 

  6. Gao, Z., Wang, L., Zhou, L., Zhang, J.: HEp-2 cell image classification with deep convolutional neural networks. IEEE J. Biomed. Health Inform. 21(2), 416–428 (2017)

    Article  Google Scholar 

  7. Goodfellow, I.J., et al.: Generative adversarial networks. arXiv preprint arXiv:1406.2661 (2014)

  8. Harandi, M., Lovell, B., Percannella, G., Saggese, A., Vento, M., Wiliem, A.: Executable thematic special issue on pattern recognition techniques for indirect immunofluorescence images analysis. Pattern Recogn. Lett. 82, 1–2 (2016)

    Google Scholar 

  9. Hobson, P., Lovell, B., Percannella, G., Vento, M., Wiliem, A.: Benchmarking human epithelial type 2 interphase cells classification methods on a very large dataset. Artif. Intell. Med. 65(3), 239–250 (2015)

    Article  Google Scholar 

  10. Lei, H., et al.: A deeply supervised residual network for HEp-2 cell classification via cross-modal transfer learning. Pattern Recogn. 79, 290–302 (2018)

    Article  Google Scholar 

  11. Li, Y., Shen, L.: HEp-Net: a smaller and better deep-learning network for HEp-2 cell classification. Comput. Methods Biomech. Biomed. Eng. Imaging Vis. 7(3), 266–272 (2019)

    Article  Google Scholar 

  12. Majtner, T., Bajić, B., Herp, J.: Texture-based image transformations for improved deep learning classification. In: 25th Iberoamerican Congress on Pattern Recognition. Springer (2021)

    Google Scholar 

  13. Majtner, T., Bajić, B., Lindblad, J., Sladoje, N., Blanes-Vidal, V., Nadimi, E.S.: On the effectiveness of generative adversarial networks as HEp-2 image augmentation tool. In: Felsberg, M., Forssén, P.-E., Sintorn, I.-M., Unger, J. (eds.) SCIA 2019. LNCS, vol. 11482, pp. 439–451. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-20205-7_36

    Chapter  Google Scholar 

  14. Meroni, P.L., Schur, P.H.: ANA screening: an old test with new recommendations. Ann. Rheum. Dis. 69(8), 1420–1422 (2010)

    Article  Google Scholar 

  15. Park, D., Park, H., Han, D.K., Ko, H.: Single image dehazing with image entropy and information fidelity. In: International Conference on Image Processing, pp. 4037–4041. IEEE (2014)

    Google Scholar 

  16. Qi, X., Zhao, G., Chen, J., Pietikäinen, M.: HEp-2 cell classification: the role of Gaussian scale space theory as a pre-processing approach. Pattern Recogn. Lett. 82, 36–43 (2016)

    Article  Google Scholar 

  17. Radford, A., Metz, L., Chintala, S.: Unsupervised representation learning with deep convolutional generative adversarial networks. arXiv preprint arXiv:1511.06434 (2015)

  18. Shen, L., Jia, X., Li, Y.: Deep cross residual network for HEp-2 cell staining pattern classification. Pattern Recogn. 82, 68–78 (2018)

    Article  Google Scholar 

  19. Vununu, C., Lee, S.H., Kwon, K.R.: A deep feature extraction method for HEp-2 cell image classification. Electronics 8(1), 20 (2019)

    Article  Google Scholar 

  20. Wetzer, E., Lindblad, J., Sintorn, I.-M., Hultenby, K., Sladoje, N.: Towards automated multiscale imaging and analysis in TEM: glomerulus detection by fusion of CNN and LBP maps. In: Leal-Taixé, L., Roth, S. (eds.) ECCV 2018. LNCS, vol. 11134, pp. 465–475. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-11024-6_36

    Chapter  Google Scholar 

  21. Wiliem, A., Sanderson, C., Wong, Y., Hobson, P., Minchin, R., Lovell, B.: Automatic classification of human epithelial type 2 cell indirect immunofluorescence images using cell pyramid matching. Pattern Recog. 47(7), 2315–2324 (2014)

    Article  Google Scholar 

  22. Wiliem, A., Wong, Y., Sanderson, C., Hobson, P., Chen, S., Lovell, B.: Classification of human epithelial type 2 cell indirect immunofluoresence images via codebook based descriptors. In: Workshop on Applications of Computer Vision, pp. 95–102. IEEE (2013)

    Google Scholar 

  23. Xie, H., He, Y., Lei, H., Han, T., Yu, Z., Lei, B.: Deeply supervised residual network for HEp-2 cell classification. In: 24th International Conference on Pattern Recognition (ICPR), pp. 699–703. IEEE (2018)

    Google Scholar 

  24. Yang, Y., Wiliem, A., Alavi, A., Hobson, P.: Classification of human epithelial type 2 cell images using independent component analysis. In: 20th International Conference on Image Processing, pp. 733–737. IEEE (2013)

    Google Scholar 

  25. Yi, X., Walia, E., Babyn, P.: Generative adversarial network in medical imaging: a review. Med. Image Anal. 58, 101552 (2019)

    Google Scholar 

  26. Zuiderveld, K.: Contrast limited adaptive histogram equalization. In: Graphics Gems IV, pp. 474–485. Academic Press Professional (1994)

    Google Scholar 

Download references

Acknowledgement

The work was supported from European Regional Development Fund-Project “Postdoc2@MUNI” (No. CZ.02.2.69/0.0/0.0/18\(\_\)053/ 0016952).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Tomáš Majtner .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Majtner, T. (2021). HEp-2 Cell Image Recognition with Transferable Cross-Dataset Synthetic Samples. In: Tsapatsoulis, N., Panayides, A., Theocharides, T., Lanitis, A., Pattichis, C., Vento, M. (eds) Computer Analysis of Images and Patterns. CAIP 2021. Lecture Notes in Computer Science(), vol 13052. Springer, Cham. https://doi.org/10.1007/978-3-030-89128-2_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-89128-2_21

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-89127-5

  • Online ISBN: 978-3-030-89128-2

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics