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A Few-Shot Learning Graph Multi-trajectory Evolution Network for Forecasting Multimodal Baby Connectivity Development from a Baseline Timepoint

Part of the Lecture Notes in Computer Science book series (LNIP,volume 12928)


Charting the baby connectome evolution trajectory during the first year after birth plays a vital role in understanding dynamic connectivity development of baby brains. Such analysis requires acquisition of longitudinal connectomic datasets. However, both neonatal and postnatal scans are rarely acquired due to various difficulties. A small body of works has focused on predicting baby brain evolution trajectory from a neonatal brain connectome derived from a single modality. Although promising, large training datasets are essential to boost model learning and to generalize to a multi-trajectory prediction from different modalities (i.e., functional and morphological connectomes). Here, we unprecedentedly explore the question: “Can we design a few-shot learning-based framework for predicting brain graph trajectories across different modalities?” To this aim, we propose a Graph Multi-Trajectory Evolution Network (GmTE-Net), which adopts a teacher-student paradigm where the teacher network learns on pure neonatal brain graphs and the student network learns on simulated brain graphs given a set of different timepoints. To the best of our knowledge, this is the first teacher-student architecture tailored for brain graph multi-trajectory growth prediction that is based on few-shot learning and generalized to graph neural networks (GNNs). To boost the performance of the student network, we introduce a local topology-aware distillation loss that forces the predicted graph topology of the student network to be consistent with the teacher network. Experimental results demonstrate substantial performance gains over benchmark methods. Hence, our GmTE-Net can be leveraged to predict atypical brain connectivity trajectory evolution across various modalities. Our code is available at


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This work was funded by generous grants from the European H2020 Marie Sklodowska-Curie action (grant no. 101003403, to I.R. and the Scientific and Technological Research Council of Turkey to I.R. under the TUBITAK 2232 Fellowship for Outstanding Researchers (no. 118C288, However, all scientific contributions made in this project are owned and approved solely by the authors. A.B is supported by the same TUBITAK 2232 Fellowship.

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Correspondence to Islem Rekik .

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Bessadok, A. et al. (2021). A Few-Shot Learning Graph Multi-trajectory Evolution Network for Forecasting Multimodal Baby Connectivity Development from a Baseline Timepoint. In: Rekik, I., Adeli, E., Park, S.H., Schnabel, J. (eds) Predictive Intelligence in Medicine. PRIME 2021. Lecture Notes in Computer Science(), vol 12928. Springer, Cham.

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