Abstract
Accurate diagnosis and prognosis of Alzheimer’s disease are crucial to develop new therapies and reduce the associated costs. Recently, with the advances of convolutional neural networks, methods have been proposed to automate these two tasks using structural MRI. However, these methods often suffer from lack of interpretability, generalization, and can be limited in terms of performance. In this paper, we propose a novel deep framework designed to overcome these limitations. Our framework consists of two stages. In the first stage, we propose a deep grading model to extract meaningful features. To enhance the robustness of these features against domain shift, we introduce an innovative collective artificial intelligence strategy for training and evaluating steps. In the second stage, we use a graph convolutional neural network to better capture AD signatures. Our experiments based on 2074 subjects show the competitive performance of our deep framework compared to state-of-the-art methods on different datasets for both AD diagnosis and prognosis.
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Acknowledgments
This work benefited from the support of the project DeepvolBrain of the French National Research Agency (ANR-18-CE45-0013). This study was achieved within the context of the Laboratory of Excellence TRAIL ANR-10-LABX-57 for the BigDataBrain project. Moreover, we thank the Investments for the future Program IdEx Bordeaux (ANR-10-IDEX-03-02), the French Ministry of Education and Research, and the CNRS for DeepMultiBrain project.
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Nguyen, HD., Clément, M., Mansencal, B., Coupé, P. (2021). Deep Grading Based on Collective Artificial Intelligence for AD Diagnosis and Prognosis. In: Reyes, M., et al. Interpretability of Machine Intelligence in Medical Image Computing, and Topological Data Analysis and Its Applications for Medical Data. IMIMIC TDA4MedicalData 2021 2021. Lecture Notes in Computer Science(), vol 12929. Springer, Cham. https://doi.org/10.1007/978-3-030-87444-5_3
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DOI: https://doi.org/10.1007/978-3-030-87444-5_3
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