Abstract
A general definition of a design might be “a pattern or template from which to create a working model of something”. We might first think of the word ‘design’ to relate to the process of development, possibly iterative, leading to a set of rules or procedures which one followed, resulting in the creation of something; something which is actually fit for purpose (i.e., it works, and presumably works well!)
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Notes
- 1.
Reproduced by kind permission of John Wiley and Sons Ltd.
- 2.
The terms ‘endpoint’ and ‘outcome’ are often taken to be synonymous, but here I use the term endpoint as a composite of outcome and the time at which that outcome is measured.
- 3.
Note that the GPRD has since been renamed as the Clinical Practice Research Datalink (CPRD).
- 4.
The word ‘regression’ will be explained much later, but for now be aware that regression methods constitute a huge part of the overall set of statistical modelling methods available to researchers.
References
Altman DG (1991) Practical statistics for medical research. Chapman and Hall, London
Evans I, Thornton H, Chalmers I, Glasziou P, Goldacre B (2011) Testing treatments: better research for better healthcare, 2nd edn. Pinter & Martin, London
Fergusson DA, Hebert P, Hogan DL, LeBel L, Rouvinez-Bouali N, Smyth JA, Sankaran K, Tinmouth A, Blajchman MA, Kovacs L, Lachance C, Lee S, Walker CR, Hutton B, Ducharme R, Balchin K, Ramsay T, Ford JC, Kakadekar A, Ramesh K, Shapiro S (2012) Effect of fresh red blood cell transfusions on clinical outcomes in premature, very low-birth-weight infants the ARIPI randomized trial. JAMA 308(14):1443–1451. https://doi.org/10.1001/2012.jama.11953
Guyatt GH, Sackett DL, Sinclair JC, Hayward R, Cook DJ, Cook RJ (1995) Users’ guides to the medical literature. IX A method for grading health care recommendations Evidence-Based Medicine Working Group. JAMA 274(22):1800–1804. https://doi.org/10.1001/jama.274.22.1800
Herrett E, Gallagher AM, Bhaskaran K, Forbes H, Mathur R, van Staa T, Smeeth L (2015) Data resource profile: clinical practice research datalink (CPRD). Int J Epidemiol 44(3):827–836. https://doi.org/10.1093/ije/dyv098
Jick H, Zornberg GL, Jick SS, Seshadri S, Drachman DA (2000) Statins and the risk of dementia. Lancet 356(9242):1627–1631. https://doi.org/10.1016/s0140-6736(00)03155-x
Kanji S (2015) Turning your research idea into a proposal worth funding. Can J Hosp Pharm 68(6):458–464. https://doi.org/10.4212/cjhp.v68i6.1502
Machin D, Campbell MJ (2005) Design of studies for medical research. Wiley, Chichester
Marmot M, Brunner E (2005) Cohort profile: the Whitehall II study. Int J Epidemiol 34(2):251–256. https://doi.org/10.1093/ije/dyh372
Pocock SJ (1983) Clinical trials: a practical approach. Wiley, Chichester
Twycross A, Shorten A (2014) Service evaluation, audit and research: what is the difference? Evid Based Nurs 17(3):65–66. https://doi.org/10.1136/eb-2014-101871
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Culliford, D. (2022). Design. In: Applied Statistical Considerations for Clinical Researchers. Springer, Cham. https://doi.org/10.1007/978-3-030-87410-0_3
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