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AtrialGeneral: Domain Generalization for Left Atrial Segmentation of Multi-center LGE MRIs

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Medical Image Computing and Computer Assisted Intervention – MICCAI 2021 (MICCAI 2021)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 12906))


Left atrial (LA) segmentation from late gadolinium enhanced magnetic resonance imaging (LGE MRI) is a crucial step needed for planning the treatment of atrial fibrillation. However, automatic LA segmentation from LGE MRI is still challenging, due to the poor image quality, high variability in LA shapes, and unclear LA boundary. Though deep learning-based methods can provide promising LA segmentation results, they often generalize poorly to unseen domains, such as data from different scanners and/or sites. In this work, we collect 140 LGE MRIs from different centers with different levels of image quality. To evaluate the domain generalization ability of models on the LA segmentation task, we employ four commonly used semantic segmentation networks for the LA segmentation from multi-center LGE MRIs. Besides, we investigate three domain generalization strategies, i.e., histogram matching, mutual information based disentangled representation, and random style transfer, where a simple histogram matching is proved to be most effective.

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This work was funded by the National Natural Science Foundation of China (grant no. 61971142, 62111530195 and 62011540404) and the development fund for Shanghai talents (no. 2020015). L. Li was partially supported by the CSC Scholarship. JA Schnabel and VA Zimmer would like to acknowledge funding from a Wellcome Trust IEH Award (WT 102431), an EPSRC programme grant (EP/P001009/1), and the Wellcome/EPSRC Center for Medical Engineering (WT 203148/Z/16/Z).

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Correspondence to Xiahai Zhuang .

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Li, L., Zimmer, V.A., Schnabel, J.A., Zhuang, X. (2021). AtrialGeneral: Domain Generalization for Left Atrial Segmentation of Multi-center LGE MRIs. In: de Bruijne, M., et al. Medical Image Computing and Computer Assisted Intervention – MICCAI 2021. MICCAI 2021. Lecture Notes in Computer Science(), vol 12906. Springer, Cham.

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