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Semi-supervised Meta-learning with Disentanglement for Domain-Generalised Medical Image Segmentation

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Medical Image Computing and Computer Assisted Intervention – MICCAI 2021 (MICCAI 2021)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 12902))

Abstract

Generalising deep models to new data from new centres (termed here domains) remains a challenge. This is largely attributed to shifts in data statistics (domain shifts) between source and unseen domains. Recently, gradient-based meta-learning approaches where the training data are split into meta-train and meta-test sets to simulate and handle the domain shifts during training have shown improved generalisation performance. However, the current fully supervised meta-learning approaches are not scalable for medical image segmentation, where large effort is required to create pixel-wise annotations. Meanwhile, in a low data regime, the simulated domain shifts may not approximate the true domain shifts well across source and unseen domains. To address this problem, we propose a novel semi-supervised meta-learning framework with disentanglement. We explicitly model the representations related to domain shifts. Disentangling the representations and combining them to reconstruct the input image allows unlabeled data to be used to better approximate the true domain shifts for meta-learning. Hence, the model can achieve better generalisation performance, especially when there is a limited amount of labeled data. Experiments show that the proposed method is robust on different segmentation tasks and achieves state-of-the-art generalisation performance on two public benchmarks. Code is publicly available at: https://github.com/vios-s/DGNet.

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Notes

  1. 1.

    With the exception of [41] which clusters unlabeled data to generate pseudo labels, but unfortunately is not applicable to segmentation.

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Acknowledgement

This work was supported by the University of Edinburgh, the Royal Academy of Engineering and Canon Medical Research Europe by a PhD studentship to Xiao Liu. This work was partially supported by the Alan Turing Institute under the EPSRC grant EP/N510129/1. We thank Nvidia for donating a Titan-X GPU. S.A. Tsaftaris acknowledges the support of Canon Medical and the Royal Academy of Engineering and the Research Chairs and Senior Research Fellowships scheme (grant RCSRF1819\(\backslash \)8\(\backslash \)25).

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Liu, X., Thermos, S., O’Neil, A., Tsaftaris, S.A. (2021). Semi-supervised Meta-learning with Disentanglement for Domain-Generalised Medical Image Segmentation. In: de Bruijne, M., et al. Medical Image Computing and Computer Assisted Intervention – MICCAI 2021. MICCAI 2021. Lecture Notes in Computer Science(), vol 12902. Springer, Cham. https://doi.org/10.1007/978-3-030-87196-3_29

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