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Selective Venous Sampling for Hypercortisolism

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Diagnosis and Management of Endocrine Disorders in Interventional Radiology

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Abstract

Inferior petrosal sinus sampling is a minimally invasive diagnostic procedure that is used to differentiate between causes of ACTH-dependent Cushing’s syndrome. More specifically, this test aides in the diagnosis of patients with ACTH-secreting pituitary tumors, or Cushing’s disease. Inferior petrosal sinus sampling has emerged as the gold standard for diagnosing Cushing’s disease, as noninvasive testing with cross-sectional imaging and laboratory assays has relatively poor sensitivity and specificity. Correct diagnosis of Cushing’s disease is important to guide treatment, which is primarily surgical resection of the tumor. We discuss the procedure in detail below, including a comprehensive approach and key technical considerations. We also briefly discuss relevant anatomy and pathophysiology.

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Author information

Authors and Affiliations

  1. Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    James P. Ho

  2. Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Sten Y. Solander

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  1. James P. Ho
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  2. Sten Y. Solander
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Correspondence to James P. Ho .

Editor information

Editors and Affiliations

  1. Division of Vascular and Interventional RadiologyDepartment of Radiology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA

    Hyeon Yu

  2. Division of Vascular and Interventional RadiologyDepartment of Radiology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA

    Charles T. Burke

  3. Division of Vascular and Interventional RadiologyDepartment of Radiology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA

    Clayton W. Commander

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Ho, J.P., Solander, S.Y. (2022). Selective Venous Sampling for Hypercortisolism. In: Yu, H., Burke, C.T., Commander, C.W. (eds) Diagnosis and Management of Endocrine Disorders in Interventional Radiology. Springer, Cham. https://doi.org/10.1007/978-3-030-87189-5_9

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  • DOI: https://doi.org/10.1007/978-3-030-87189-5_9

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-87188-8

  • Online ISBN: 978-3-030-87189-5

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