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Oral Graft-Versus-Host Disease

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Abstract

Graft-versus-host disease (GVHD) as a consequence of hematopoietic stem cell transplantation (HSCT) is covered in this chapter. The different types of GVHD and late complications are also described with relevant management strategies.

Keywords

  • Oral
  • GVHD
  • HSCT

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  • DOI: 10.1007/978-3-030-86510-8_14
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Bibliography

  1. Barbash B, Kramer S, Tzimas D, Saitta P. Graft-versus-host disease of the upper gastrointestinal tract after an autologous stem cell transplant. ACG Case Rep J. 2014;2(1):55–7.

    CrossRef  Google Scholar 

  2. Batra A, Cottler-Fox M, Harville T, Rhodes-Clark BS, Makhoul I, Nakagawa M. Autologous graft versus host disease: an emerging complication in patients with multiple myeloma. Bone Marrow Res. 2014;2014:891427.

    CrossRef  Google Scholar 

  3. Carpenter PA, Kitko CL, Elad S, Flowers ME, Gea-Banacloche JC, Halter JP, et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: V. The 2014 Ancillary Therapy and Supportive Care Working Group report. Biol Blood Marrow Transplant. 2015;21(7):1167–87.

    CrossRef  Google Scholar 

  4. Cutler C, Nekhlyudov L, Rosmarin A. The approach to hematopoietic cell transplantation survivorship. UpToDate; 2017.

    Google Scholar 

  5. Cornell RF, Hari P, Drobyski WR. Engraftment syndrome after autologous stem cell transplantation: an update unifying the definition and management approach. Biol Blood Marrow Transplant. 2015;21(12):2061–8.

    CrossRef  Google Scholar 

  6. Cutler C, Miklos D, Kim HT, Treister N, Woo SB, Bienfang D, et al. Rituximab for steroid-refractory chronic graft-versus-host disease. Blood. 2006;108(2):756–62.

    CrossRef  Google Scholar 

  7. DePalo J, Chai X, Lee SJ, Cutler CS, Treister N. Assessing the relationship between oral chronic graft-versus-host disease and global measures of quality of life. Oral Oncol. 2015;51(10):944–9.

    CrossRef  Google Scholar 

  8. Filipovich AH, Weisdorf D, Pavletic S, Socie G, Wingard JR, Lee SJ, et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report. Biol Blood Marrow Transplant. 2005;11(12):945–56.

    CrossRef  Google Scholar 

  9. Holmberg L, Kikuchi K, Gooley TA, Adams KM, Hockenbery DM, Flowers ME, et al. Gastrointestinal graft-versus-host disease in recipients of autologous hematopoietic stem cells: incidence, risk factors, and outcome. Biol Blood Marrow Transplant. 2006;12(2):226–34.

    CrossRef  Google Scholar 

  10. Ion D, Stevenson K, Woo SB, Ho VT, Soiffer R, Antin JH, et al. Characterization of oral involvement in acute graft-versus-host disease. Biol Blood Marrow Transplant. 2014;20(11):1717–21.

    CrossRef  Google Scholar 

  11. Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. The 2014 Diagnosis and Staging Working Group report. Biol Blood Marrow Transplant. 2015;21(3):389–401.e1.

    CrossRef  Google Scholar 

  12. Kharfan-Dabaja MA, Mhaskar AR, Djulbegovic B, Cutler C, Mohty M, Kumar A. Efficacy of rituximab in the setting of steroid-refractory chronic graft-versus-host disease: a systematic review and meta-analysis. Biol Blood Marrow Transplant. 2009;15(9):1005–13.

    CrossRef  Google Scholar 

  13. Korngold R, Antin JH. Biology and management of acute graft-versus-host disease. Cancer Treat Res. 2009;144:257–75.

    CrossRef  Google Scholar 

  14. Kuten-Shorrer M, Woo SB, Treister NS. Oral graft-versus-host disease. Dent Clin N Am. 2014;58(2):351–68.

    CrossRef  Google Scholar 

  15. Lee SJ, Vogelsang G, Flowers ME. Chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2003;9(4):215–33.

    CrossRef  Google Scholar 

  16. Mawardi H, Elad S, Correa ME, Stevenson K, Woo SB, Almazrooa S, et al. Oral epithelial dysplasia and squamous cell carcinoma following allogeneic hematopoietic stem cell transplantation: clinical presentation and treatment outcomes. Bone Marrow Transplant. 2011;46(6):884–91.

    CrossRef  Google Scholar 

  17. Mawardi H, Hashmi SK, Elad S, Aljurf M, Treister N. Chronic graft-versus-host disease: current management paradigm and future perspectives. Oral Dis. 2018;25(4):931–48.

    CrossRef  Google Scholar 

  18. Motta A, Zhan Q, Larson A, Lerman M, Woo SB, Soiffer RJ, et al. Immunohistopathological characterization and the impact of topical immunomodulatory therapy in oral chronic graft-versus-host disease: a pilot study. Oral Dis. 2018;24(4):580–90.

    CrossRef  Google Scholar 

  19. Nassereddine S, Rafei H, Elbahesh E, Tabbara I. Acute graft versus host disease: a comprehensive review. Anticancer Res. 2017;37(4):1547–55.

    CrossRef  Google Scholar 

  20. Teshima T, Reddy P, Zeiser R. Reprint of: Acute graft-versus-host disease: novel biological insights. Biol Blood Marrow Transplant. 2016;22(3 Suppl):S3–8.

    CrossRef  Google Scholar 

  21. Treister N, Chai X, Kurland B, Pavletic S, Weisdorf D, Pidala J, et al. Measurement of oral chronic GVHD: results from the chronic GVHD consortium. Bone Marrow Transplant. 2013;48(8):1123–8.

    CrossRef  Google Scholar 

  22. Treister N, Duncan C, Cutler C, Lehmann L. How we treat oral chronic graft-versus-host disease. Blood. 2012;120(17):3407–18.

    CrossRef  Google Scholar 

  23. Treister N, Li S, Lerman MA, Lee S, Soiffer R. Narrow-band UVB phototherapy for management of oral chronic graft-versus-host disease. Photodermatol Photoimmunol Photomed. 2015;31(2):75–82.

    CrossRef  Google Scholar 

  24. Treister NS, Stevenson K, Kim H, Woo SB, Soiffer R, Cutler C. Oral chronic graft-versus-host disease scoring using the NIH consensus criteria. Biol Blood Marrow Transplant. 2010;16(1):108–14.

    CrossRef  Google Scholar 

  25. Wolff D, Gerbitz A, Ayuk F, Kiani A, Hildebrandt GC, Vogelsang GB, et al. Consensus conference on clinical practice in chronic graft-versus-host disease (GVHD): first-line and topical treatment of chronic GVHD. Biol Blood Marrow Transplant. 2010;16(12):1611–28.

    CrossRef  Google Scholar 

  26. Zeiser R, Blazar BR. Pathophysiology of chronic graft-versus-host disease and therapeutic targets. N Engl J Med. 2017;377(26):2565–79.

    CrossRef  Google Scholar 

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Correspondence to Alessandro Villa .

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Villa, A., Bajonaid, A. (2022). Oral Graft-Versus-Host Disease. In: Nair, R. (eds) Orofacial Supportive Care in Cancer . Springer, Cham. https://doi.org/10.1007/978-3-030-86510-8_14

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  • DOI: https://doi.org/10.1007/978-3-030-86510-8_14

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-86509-2

  • Online ISBN: 978-3-030-86510-8

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