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Conclusions and Outlook

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Dissipation and Control in Microscopic Nonequilibrium Systems

Part of the book series: Springer Theses ((Springer Theses))

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Abstract

Throughout this thesis, we discussed a range of topics, all concerned with the general goal of better understanding the energetic and entropic flows in microscopic systems operating out of thermodynamic equilibrium. Beginning with the experimental design of efficient unfolding protocols of a DNA hairpin, we added confidence that simple near-equilibrium models can have significant utility in understanding the nonequilibrium physics of in vivo biological systems. Continuing, our theoretical investigations throughout the remainder of the thesis generalized the existing framework of optimal control in stochastic systems and embedded this framework into the broader context of stochastic thermodynamics. Ultimately, this body of research paves the way to more accurately treat the inner workings of biological molecular machines through the lens of control theory, towards the end of understanding the evolutionary design principles underlying their design.

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Notes

  1. 1.

    There are subtle, but important differences between splitting the entropy production into that which is due to each subsystem’s dynamics, and that which is due to visible and hidden coordinates, even if one of the systems is visible and the other is hidden. Ultimately, this is because the transition rates of the visible system depend—through local detailed balance—on the state of the hidden system.

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  1. Viewpoint Investment Partners, Calgary, AB, Canada

    Steven J. Large

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  1. Steven J. Large
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Large, S.J. (2021). Conclusions and Outlook. In: Dissipation and Control in Microscopic Nonequilibrium Systems. Springer Theses. Springer, Cham. https://doi.org/10.1007/978-3-030-85825-4_11

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