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Injections of Synovial Mesenchymal Stromal Cells

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Orthobiologics

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Abstract

Mesenchymal stromal cells (MSCs) isolated from the synovium are attractive because synovial MSCs have a high chondrogenic and proliferative potential. Periodic injections of synovial MSCs inhibited osteoarthritis (OA) progression and attenuated synovitis in a rat OA model. Most of the synovial MSCs injected into the knee joint migrated into the synovium, the surviving cells maintained their MSC properties, and they produced lubricin and BMPs for cartilage homeostasis and TSG-6 for anti-inflammation. Based on our basic research, we initiated a clinical study in which synovial MSCs were injected into OA knees twice. The primary endpoint is the detection of an inhibition of cartilage loss in the OA knee after injections of synovial MSCs. This study is distinctive for that the quantitative evaluation for cartilage is based on three-dimensional MRI analysis.

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Authors and Affiliations

  1. Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University (TMDU), Tokyo, Japan

    Ichiro Sekiya & Nobutake Ozeki

Authors
  1. Ichiro Sekiya
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  2. Nobutake Ozeki
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Correspondence to Ichiro Sekiya .

Editor information

Editors and Affiliations

  1. Rizzoli Orthopaedic Institute, Bologna, Italy

    Giuseppe Filardo

  2. Orthopaedic & Sports Medicine Group, Santa Monica Orthopaedic & Sports Medicine, Santa Monica, CA, USA

    Bert R. Mandelbaum

  3. Orthopaedic Surgery and Biomedical Engineering, Cleveland Clinic, Cleveland, OH, USA

    George F. Muschler

  4. Hospital for Special Surgery, New York, NY, USA

    Scott A. Rodeo

  5. Institute for Medical Science in Sports, Osaka Health Science University, Osaka, Japan

    Norimasa Nakamura

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Sekiya, I., Ozeki, N. (2022). Injections of Synovial Mesenchymal Stromal Cells. In: Filardo, G., Mandelbaum, B.R., Muschler, G.F., Rodeo, S.A., Nakamura, N. (eds) Orthobiologics. Springer, Cham. https://doi.org/10.1007/978-3-030-84744-9_4

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  • DOI: https://doi.org/10.1007/978-3-030-84744-9_4

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-84743-2

  • Online ISBN: 978-3-030-84744-9

  • eBook Packages: MedicineMedicine (R0)

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