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Gene Therapy

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Orthobiologics

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Abstract

The treatment of musculoskeletal disorders such as focal articular cartilage defects, osteoarthritis, bone fractures, ruptured tendons and ligaments, and meniscal tears remains challenging for the clinicians due to the difficulty to stably repair the damaged tissues and to reproduce original structures with fully functional mechanical competences. Injectable gene therapy is a promising approach to treat a variety of musculoskeletal disorders affecting the articular cartilage, bones, tendons/ligaments, and meniscus by providing gene-based therapeutic agents over extended periods of time. Such a clinically adapted approach may offer means to activate, rejuvenate, and/or enhance the intrinsic repair abilities of the affected tissues in a non-invasive manner by directly injecting therapeutic sequences coding for reparative factors in sites of injury. The goal of this chapter is to discuss the most up-to-date experimental strategies and outcomes in clinically relevant in vivo models of the diseases that may be translated in the future into clinical therapies to achieve an efficient, safe, and durable healing of the lesions in translational applications.

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Authors and Affiliations

  1. Center of Experimental Orthopaedics, Saarland University Medical Center, Homburg/Saar, Germany

    Magali Cucchiarini

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  1. Magali Cucchiarini
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Editors and Affiliations

  1. Rizzoli Orthopaedic Institute, Bologna, Italy

    Giuseppe Filardo

  2. Orthopaedic & Sports Medicine Group, Santa Monica Orthopaedic & Sports Medicine, Santa Monica, CA, USA

    Bert R. Mandelbaum

  3. Orthopaedic Surgery and Biomedical Engineering, Cleveland Clinic, Cleveland, OH, USA

    George F. Muschler

  4. Hospital for Special Surgery, New York, NY, USA

    Scott A. Rodeo

  5. Institute for Medical Science in Sports, Osaka Health Science University, Osaka, Japan

    Norimasa Nakamura

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Cucchiarini, M. (2022). Gene Therapy. In: Filardo, G., Mandelbaum, B.R., Muschler, G.F., Rodeo, S.A., Nakamura, N. (eds) Orthobiologics. Springer, Cham. https://doi.org/10.1007/978-3-030-84744-9_31

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