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Ligament Lesions: Biologics

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Orthobiologics

Abstract

Surgical biologic augmentation techniques, known as orthobiologics, have been progressively increasing in the past decade. The most popular and evidence-based orthobiologic currently used as an adjuvant for conservative and surgical approaches in the treatment of ligament injuries is platelet-rich plasma (PRP). PRP has shown biologic properties that have enhanced cell proliferation, migration, differentiation, and angiogenesis, which may help restore native tissues, with promising results in promoting ligament and bone healing while reducing risks for treatment failure. One of the main applications that have been studied is in anterior cruciate ligament reconstruction, while conservative injective applications have been performed to address partial anterior cruciate ligament injuries, medial collateral ligament lesions, as well as ankle sprains. However, there are inconsistencies in basic science and clinical results, with a paucity of high-level evidence studies. This chapter aims at reviewing the latest available evidence and discussing the rationale for the use of PRP in ligament injuries around the knee and ankle sprains.

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Authors and Affiliations

  1. Facultad Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile

    David Figueroa, Rodrigo Guiloff & Francisco Figueroa

Authors
  1. David Figueroa
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  2. Rodrigo Guiloff
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  3. Francisco Figueroa
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Editor information

Editors and Affiliations

  1. Rizzoli Orthopaedic Institute, Bologna, Italy

    Giuseppe Filardo

  2. Orthopaedic & Sports Medicine Group, Santa Monica Orthopaedic & Sports Medicine, Santa Monica, CA, USA

    Bert R. Mandelbaum

  3. Orthopaedic Surgery and Biomedical Engineering, Cleveland Clinic, Cleveland, OH, USA

    George F. Muschler

  4. Hospital for Special Surgery, New York, NY, USA

    Scott A. Rodeo

  5. Institute for Medical Science in Sports, Osaka Health Science University, Osaka, Japan

    Norimasa Nakamura

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Figueroa, D., Guiloff, R., Figueroa, F. (2022). Ligament Lesions: Biologics. In: Filardo, G., Mandelbaum, B.R., Muschler, G.F., Rodeo, S.A., Nakamura, N. (eds) Orthobiologics. Springer, Cham. https://doi.org/10.1007/978-3-030-84744-9_21

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  • DOI: https://doi.org/10.1007/978-3-030-84744-9_21

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-84743-2

  • Online ISBN: 978-3-030-84744-9

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