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Ligament Lesions: Cell Therapy

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Orthobiologics

Abstract

There is a paucity in the orthopedic literature regarding the use of cell therapies for ligament injuries. A majority of the existing literature on this topic is preclinical, considers small case series, or comprises anecdotal, editorial-type articles, with limited long-term clinical outcomes, mainly on the anterior cruciate ligament (ACL). At this time there are no studies, clinical or preclinical, that specifically examine the effects of cell therapies on other ligaments like fibular collateral ligament (FCL) or posterior cruciate ligament (PCL) injuries. The use of cell therapy agents in the setting of ligament injury has yielded promising results in preclinical in vitro models, but there is a lack of clinical studies to validate these findings. Additionally, there remains only one case study which investigated the effects of cell therapy in ulnar collateral ligament reconstruction. Considering this relative paucity, further research is needed to investigate the utility of cell therapies with respect to ligament injuries. Promising science should not be blindly implemented without clinical trials demonstrating successful, safe, and reproducible patient outcomes.

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Authors and Affiliations

  1. Twin City Orthopedics, Edina, MN, USA

    Robert S. Dean, Nicholas N. DePhillipo & Robert F. LaPrade

  2. Oslo Sports Trauma Research Center, Oslo, Norway

    Nicholas N. DePhillipo

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  1. Robert S. Dean
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  2. Nicholas N. DePhillipo
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  3. Robert F. LaPrade
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Editors and Affiliations

  1. Rizzoli Orthopaedic Institute, Bologna, Italy

    Giuseppe Filardo

  2. Orthopaedic & Sports Medicine Group, Santa Monica Orthopaedic & Sports Medicine, Santa Monica, CA, USA

    Bert R. Mandelbaum

  3. Orthopaedic Surgery and Biomedical Engineering, Cleveland Clinic, Cleveland, OH, USA

    George F. Muschler

  4. Hospital for Special Surgery, New York, NY, USA

    Scott A. Rodeo

  5. Institute for Medical Science in Sports, Osaka Health Science University, Osaka, Japan

    Norimasa Nakamura

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Robert S. Dean declares that he has no conflict of interest.

Nicholas N. DePhillipo declares that he has no conflict of interest.

Robert F. LaPrade reports grants and personal fees from Arthrex, Inc, grants from Linvatec, grants and personal fees from Ossur, grants and personal fees from Smith & Nephew, outside the submitted work.

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Dean, R.S., DePhillipo, N.N., LaPrade, R.F. (2022). Ligament Lesions: Cell Therapy. In: Filardo, G., Mandelbaum, B.R., Muschler, G.F., Rodeo, S.A., Nakamura, N. (eds) Orthobiologics. Springer, Cham. https://doi.org/10.1007/978-3-030-84744-9_20

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