Abstract
Developmental lung lesions are a spectrum of entities with much overlap of histological features. The incidence is not known, but the diagnosis has become more frequent in the last two decades with the worldwide expansion of prenatal ultrasound. Their exact pathogenesis has not been fully elucidated yet, but the overlapping histological features and recent advances in the field of molecular diagnosis suggest that these lesions share a common origin, and their differences may be the result of variations in the timing of their development and/or the location within the tracheobronchial tree. They can present in a wide range of clinical scenarios, from prenatal hydrops and death, to being completely asymptomatic with postnatal spontaneous involution. The management of symptomatic lesions does not present a clinical challenge, but the proper approach to asymptomatic lesions remains controversial.
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Notes
- 1.
J. Thomas Stocker—pathologist at Armed Forces Institute of Pathology (to 2011), Washington DC.
- 2.
N. Scott Adzick—pediatric surgeon at Children’s Hospital of Philadelphia.
Further Reading
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Laje, P. (2022). Developmental Lung Lesions. In: Sinha, C.K., Davenport, M. (eds) Handbook of Pediatric Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-84467-7_13
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DOI: https://doi.org/10.1007/978-3-030-84467-7_13
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