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Macrophage Targeting by Nanocarriers for Therapy of Autoimmune Diseases

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Macrophage Targeted Delivery Systems

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Abstract

Macrophages and monocytes are essentially the cells of the innate immune system residing in all tissues that include liver and adipose tissue. Owing to their phenotypic flexibility, they play critical roles in tissue homeostasis, but they may also contribute to the initiation and progression of metabolic disorders. Targeted drug delivery to the macrophages appears to be an attractive proposition to improve therapeutic efficacy of enclosed drug. Thus, they are ideal therapeutic targets for diseases such as insulin resistance, nonalcoholic fatty liver disease, and atherosclerosis. Currently, development in the field of drug delivery has enabled phenotype-specific targeting of macrophages. Macrophages can be exploited as Trojan horses for targeted drug delivery. Nanocarriers can migrate across the different membrane barriers and release their drug cargo at sites of infection. In this review, we deliberate on the advances in therapeutics for autoimmune disorders via macrophage-specific delivery.

We highlight microspheres/microparticles, liposomes, nanoparticles, dendrimers, metallic lipid nanoparticles for targeted delivery to the macrophages and how they can be optimized to alter the macrophage phenotype to exploit its therapeutic potential to combat metabolically favorable tissue environment.

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Author notes

  1. Authors Largee Biswas and Monika Yadav have equally contributed to this chapter.

Authors and Affiliations

  1. Nanobiotech Lab, Department of Zoology, Kirori Mal College, University of Delhi, Delhi, India

    Largee Biswas, Monika Yadav, Priyanka Singh & Anita Kamra Verma

  2. Department of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University, New Delhi, India

    Sushma Talegaonkar

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  1. Largee Biswas
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  2. Monika Yadav
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  3. Priyanka Singh
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  4. Sushma Talegaonkar
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  5. Anita Kamra Verma
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Correspondence to Anita Kamra Verma .

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Editors and Affiliations

  1. Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University Uttar Pradesh, Noida, India

    Swati Gupta

  2. University of South Florida, Taneja College of Pharmacy, Tampa, FL, USA

    Yashwant V. Pathak

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Biswas, L., Yadav, M., Singh, P., Talegaonkar, S., Verma, A.K. (2022). Macrophage Targeting by Nanocarriers for Therapy of Autoimmune Diseases. In: Gupta, S., Pathak, Y.V. (eds) Macrophage Targeted Delivery Systems. Springer, Cham. https://doi.org/10.1007/978-3-030-84164-5_14

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