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New Insights into and Updates on Antimicrobial Agents

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Emerging Modalities in Mitigation of Antimicrobial Resistance

Abstract

Infectious diseases are one of the major considerable factors in the rising universal mortality and morbidity rate. The frequency of microbial infections is gaining higher in communities due to the sudden ingress of life-threatening newer pathogens or the acquired emergence of drug-resistant pathogenic microbes. Extensive misuse and overuse in clinical practices led to the development of reduced susceptibility of the drugs to the current armamentarium of antimicrobial agents. Undoubtedly, antimicrobial agents play a remarkable role to support science in order to eradicate microbial infections to a certain level and also help to accelerate the development of newer antimicrobial drugs to combat microbial drug-resistant issues. In the finding of newer drugs, natural sources or herbal medicines have been proved to be excellent resources of antimicrobial compounds in the present time. These potent newer natural derived molecules have been shown to save lives against severe infectious diseases and also reduce the burden of illness in certain clinical situations. Many natural compounds and antibiotics isolated from microbes or microbial strains also face strong challenges due to their ineffectiveness when other strains get developed resistance against such molecules. To eradicate these major issues, scientists and researchers are now well focused on the development of efflux pump inhibitors to combat this emerging seriousness against a wide variety of spectrum by giving life to the ineffective/old antibiotics.

The issue we’re answering in this chapter is whether natural sources that contain a wide spectrum of bioactive secondary metabolites can able to confer new antibiotics to fight MDR microbes and novel chemotherapy stimulators to restore old antibiotics to become therapeutically effective. The key aim of this research is to illustrate the possible benefits of a number of naturally derived compounds as well as the role of phytochemicals in the growth of biocompatible therapeutics. This study also focuses on the different effects and efficacy of natural compounds in controlling MDR in bacteria, with the aim of promoting research into unexplored plants in order to find new antibiotics for global health benefits.

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Dwibedi, V., Rath, S.K. (2022). New Insights into and Updates on Antimicrobial Agents. In: Akhtar, N., Singh, K.S., Prerna, Goyal, D. (eds) Emerging Modalities in Mitigation of Antimicrobial Resistance. Springer, Cham. https://doi.org/10.1007/978-3-030-84126-3_9

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