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Pre-Analytic Phase: Specimen Type and Acquisition

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Abstract

The type of specimen, how and where it is obtained, is in many cases outside the direct control of the pathologist. This state of affairs, albeit inevitable for reasons of cost and logistics, contributes to many of the problems that follow and may from the very beginning preclude the possibility of reliable assay results. Specimens derive from diverse sources in each health care system, from multiple clinics and operating rooms manned by various clinical and surgical departments, which makes it difficult, or impossible, to establish and adhere to a rigorous protocol for fixation and processing. In most cases total duration of exposure to fixative(s) is at best an estimate, and indeed in large specimens may vary to an unknown degree, from periphery to center, due to differences in tissue size, density and rate of penetration of fixative.

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  • DOI: 10.1007/978-3-030-84087-7_6
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Jasani, B., Huss, R., Taylor, C.R. (2021). Pre-Analytic Phase: Specimen Type and Acquisition. In: Precision Cancer Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-84087-7_6

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  • DOI: https://doi.org/10.1007/978-3-030-84087-7_6

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-84086-0

  • Online ISBN: 978-3-030-84087-7

  • eBook Packages: MedicineMedicine (R0)