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Analytical Phase: Current Controls; Fit for Purpose Selection and Validation

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Abstract

In the preceding discussion of required characteristics of controls, reference was made to the types of materials (including archival tissues) that are available today and may be adapted to fill the range of necessary IHC controls. Reference also was made to the AIMM Control Series of papers that represent the most complete published survey of how to establish optimal control systems. The current text is focused upon principles and limitations that may affect outcome of biomarker testing; for practical recommendations on how to establish optimal control systems the original AIMM control series should be consulted. These papers are listed in Table 10.1 for convenience; their content underlies much of the basis of this chapter.

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Jasani, B., Huss, R., Taylor, C.R. (2021). Analytical Phase: Current Controls; Fit for Purpose Selection and Validation. In: Precision Cancer Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-84087-7_10

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  • DOI: https://doi.org/10.1007/978-3-030-84087-7_10

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