Glycolysis has been one of the major hallmarks of cancer, as cancer cells exhibit a high rate of glucose consumption beyond that required for energy production. Glucose acts as a substrate to generate biomass and regulates cell signaling that is required for the cancer progression. Glucose transporters (GLUTs) have been majorly playing their role in glucose transport across the cell membrane to meet their metabolic demands. Overexpression of GLUTs has been reported in various cancer types. Also, activation of certain oncogenes such as c-myc, ras, and src and several other transcription factors such as hypoxia inducible factor-1α induces the overexpression of GLUTs in cancer cells. GLUT regulation has been studied on the epigenetic level as well to provide fundamental information on its regulation. Targeting and understanding GLUTs function in cancer cells could pave novel path for therapeutic strategies against cancer.
- Warburg effect
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Raj, S. et al. (2021). Regulation of Glucose Transporters in Cancer Progression. In: Kesari, K.K., Jha, N.K. (eds) Free Radical Biology and Environmental Toxicity. Molecular and Integrative Toxicology. Springer, Cham. https://doi.org/10.1007/978-3-030-83446-3_9
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