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Metabolomics Application in Fetal Medicine

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Perinatology

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Abstract

Metabolomics has begun to revolutionize many fields of biomedicine. Indeed, various disease states can be reflected by changes in metabolite concentrations. Metabolomics allows the simultaneous measurement of a large number of biomolecules on a single biological sample. Metabolomics strategies have been increasingly exploited to understand the metabolic adaptations of the human organism in pregnancy and to characterize deviant behavior caused by prenatal complications. Several types of biomaterial can be collected and investigated. All of them enable the determination of the maternal and fetal state, but their biochemical interactions pose a number of challenges for the obstetric scientific world. The aim of our study was to collect evidences in metabolomics research and prenatal medicine, considering several pathological or physiological aspects of pregnancy. The development of new approaches to find reliable biomarkers is crucial to introduce new knowledge and panels for the diagnosis and classification of different diseases.

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Authors and Affiliations

  1. Department of Prenatal and Preimplantation Genetic Diagnosis and Fetal Therapy, Ospedale Pediatrico Microcitemico “A. Cao”, Cagliari, Italy

    G. Monni, V. Corda & A. Iuculano

  2. Clinical Metabolomics Unit, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy

    F. Murgia & L. Atzori

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  1. G. Monni
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  2. F. Murgia
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  3. V. Corda
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  4. A. Iuculano
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  5. L. Atzori
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Editors and Affiliations

  1. Maternal and Child Department, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil

    Renato Augusto Moreira de Sá

  2. Federal University of Paraíba, João Pessoa, Paraíba, Brazil

    Eduardo Borges da Fonseca

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Monni, G., Murgia, F., Corda, V., Iuculano, A., Atzori, L. (2022). Metabolomics Application in Fetal Medicine. In: Moreira de Sá, R.A., Fonseca, E.B.d. (eds) Perinatology. Springer, Cham. https://doi.org/10.1007/978-3-030-83434-0_30

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