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Implications of Inflammation in Aging and Age-Related Diseases

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The Role of Antioxidants in Longevity and Age-Related Diseases

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Abstract

Research evidence has indicated that increasing numbers of elderly are suffering from age-related diseases such as neurodegenerative disease, atherosclerosis, cancer, diabetes, and osteoporosis. These diseases are characterized by progressive loss of tissue and organ function. Substantial evidence has revealed that the overproduction of ROS may play a crucial role in the development of these diseases. Oxidative stress is regarded as an imbalance between antioxidant and prooxidant species and thus leads to cellular and molecular damage. ROS are produced within the biological system to mediate cellular processes, for instance, stressor response, inflammation, and cell survival. The elderly are vulnerable to oxidative stress due to a reduction in the efficiency of the endogenous antioxidant system. Despite ROS production may not be an essential factor for aging, they are more likely to aggravate age-related diseases development through interaction with mitochondria and oxidative damage. The exact molecular mode of actions of aging and age-related diseases linked to the disturbance of redox balance remains unclear. In this chapter, we discussed the role of inflammation in the pathological mechanisms of obesity, neurodegenerative disease, atherosclerosis, cancer, diabetes, and osteoporosis.

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  1. Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

    Bee Ling Tan & Mohd Esa Norhaizan

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Tan, B.L., Norhaizan, M.E. (2021). Implications of Inflammation in Aging and Age-Related Diseases. In: The Role of Antioxidants in Longevity and Age-Related Diseases . Springer, Cham. https://doi.org/10.1007/978-3-030-82859-2_5

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