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Chronic Inflammation and Aging (Inflammaging)

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The Role of Antioxidants in Longevity and Age-Related Diseases

Abstract

Research evidence has revealed that the molecular inflammatory process plays a central role in the aging process and age-related diseases. Inflammaging is a systemic, low-grade, and chronic inflammation in aging, which is occurred in the absence of overt infection. Chronic inflammation is often derived from the macromolecules or damaged cells due to an increased production or inadequate elimination. The ability of the gut to sequester harmful microbes reduced with age. Hence, several harmful products that are generated from the microbial components of the human body, for instance, gut microbiota, are capable of permeable into surrounding tissues, and thus contribute to chronic inflammation. In this chapter, we summarized the cellular processes/pathways that are known to modulate chronic inflammation in age-related diseases and aging.

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  1. Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

    Bee Ling Tan & Mohd Esa Norhaizan

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Tan, B.L., Norhaizan, M.E. (2021). Chronic Inflammation and Aging (Inflammaging). In: The Role of Antioxidants in Longevity and Age-Related Diseases . Springer, Cham. https://doi.org/10.1007/978-3-030-82859-2_4

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