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Phenobarbital

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Antiseizure Medication Interactions

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Abstract

The pharmacokinetic characteristics of phenobarbital are described and the interaction effects of concomitant antiseizure medications on phenobarbital in terms of its pharmacokinetics and pharmacodynamics are highlighted.

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References

  1. Kelly WN, Richardson AP, Mason MF, Rector FC. Acetazolamide in phenobarbital intoxication. Arch Intern Med. 1966;117:64–9.

    Article  Google Scholar 

  2. Moseley BD, Otoul C, Staelens L, Stockis A. Pharmacokinetic interaction of brivaracetam on other antiepileptic drugs in adults with focal seizures: pooled analysis of data from randomized clinical trials. Epilepsy Res. 2019;158:106218.

    Article  CAS  Google Scholar 

  3. Gaston TE, Bekib EM, Cutter GR, Liu Y, Szaflarski JP, UAB CBD Program. Interactions between cannabidiol and commonly used antiepileptic drugs. Epilepsia. 2017;58:1586–92.

    Article  CAS  Google Scholar 

  4. Eadie MJ, Lander CM, Hooper WD, Tyrer JH. Factors influencing phenobarbitone levels in epileptic patients. Br J Clin Pharmacol. 1977;4:541–7.

    Article  CAS  Google Scholar 

  5. Bialer M, Johannessen SI, Koepp MJ, Levy RH, Perucca E, Perucca P, Tomson T, White HS. Progress report on new antiepileptic drugs: a summary of the fifteenth Eilat conference on new antiepileptic drugs and devices (EILAT XV). II. Drugs in more advanced clinical development. Epilepsia. 2020;61:2365–85.

    Article  CAS  Google Scholar 

  6. Vakil SD, Critchley EMR, Cocks A, Hayward HW. The effect of clobazam on blood levels of phenobarbitone, phenytoin and carbamazepine (preliminary report). Royal Society of Medicine International Congress and Symposium Series no. 43. London; 1981. p. 165–167.

    Google Scholar 

  7. Nanda RN, Johnson RH, Keogh HJ, Lambie DG, Melville ID. Treatment of epilepsy with clonazepam and its effect on other anti-convulsants. J Neurol Neurosurg Psychiatry. 1977;40:538–43.

    Article  CAS  Google Scholar 

  8. Falcao A, Fuseau E, Nunes T, Almeida L, Soares-da-Silva P. Pharmacokinetics, drug interactions and exposure-response relationships of eslicarbazepine acetate in adult patients with partial-onset seizures: population pharmacokinetic and pharmacokinetic/pharmacodynamic analysis. CNS Drugs. 2012;26:79–91.

    Article  CAS  Google Scholar 

  9. Schmidt D. The effect of phenytoin and ethosuximide on primidone metabolism in patients with epilepsy. J Neurol. 1975;209:115–23.

    Article  CAS  Google Scholar 

  10. Reidenberg P, Glue P, Banfield CR, Colucci RD, Meehan JW, Radwanski E, Mojavarian P, Lin CC, Nezamis J, Guillaume M, Affrime MB. Effects of felbamate on the pharmacokinetics of phenobarbital. Clin Pharmacol Ther. 1995;58:279–87.

    Article  CAS  Google Scholar 

  11. Hooper WD, Kavanagh MC, Herkes GK, Eadie MJ. Lack of a pharmacokinetic interaction between phenobarbitone and gabapentin. Br J Clin Pharmacol. 1991;31:171–4.

    Article  CAS  Google Scholar 

  12. Eriksson AS, Hoppu K, Nergardh A, Boreu L. Pharmacokinetic interactions between lamotrigine and other antiepileptic drugs in children with intractable epilepsy. Epilepsia. 1996;37:769–73.

    Article  CAS  Google Scholar 

  13. Perucca E, Baltes E, Ledent E. Levetiracetam: absence of pharmacokinetic interactions with other antiepileptic drugs (AEDs). Epilepsia. 2000;41(Suppl):150.

    Google Scholar 

  14. Rambeck B. Pharmacological interactions of methsuximide with phenobarbital and phenytoin in hospitalized epileptic patients. Epilepsia. 1979;20:147–56.

    Article  CAS  Google Scholar 

  15. Barcs G, Walker EB, Elger CE, Scaramelli A, Stefan H, Sturm Y, Moore A, Flesch G, Kramer L, D’Souza J. Oxcarbazepine placebo-controlled, dose-ranging trial in refractory partial epilepsy. Epilepsia. 2000;41:1597–607.

    Article  CAS  Google Scholar 

  16. Patsalos PN. The clinical pharmacology profile of the new antiepileptic drug perampanel: a novel noncompetitive AMPA receptor antagonist. Epilepsia. 2015;56:12–27.

    Article  CAS  Google Scholar 

  17. Gidal BE, Ferry J, Majid O, Hussein Z. Concentration-effect relationships with perampanel in patients with pharmacoresistant partial-onset seizures. Epilepsia. 2013;54:1490–7.

    Article  CAS  Google Scholar 

  18. Lambie DG, Johnson RH. The effect of phenytoin on phenobarbitone and primidone metabolism. J Neurol Neurosurg Psychiatry. 1981;44:148–51.

    Article  CAS  Google Scholar 

  19. Summary of product characteristics: Piracetam (Nootropil). UCB Pharma Ltd. Last update 9 Feb 2017.

    Google Scholar 

  20. Bockbrader HN, Burger P, Knapp L. Pregabalin effect on steady-state pharmacokinetics of carbamazepine, lamotrigine, phenobarbital, phenytoin, topiramate, valproate, and tiagabine. Epilepsia. 2011;52:405–9.

    CAS  PubMed  Google Scholar 

  21. Perucca E, Cloyd J, Critchley D, Fuseau E. Rufinamide: clinical pharmacokinetics and concentration-response relationships in patients with epilepsy. Epilepsia. 2008;49:1123–41.

    Article  CAS  Google Scholar 

  22. Levy RH, Loiseau P, Guyot M, Blehaut H, Tor J, Moreland TA. Stiripentol kinetics in epilepsy: nonlinearity and interactions. Clin Pharmacol Ther. 1984;36:661–9.

    Article  CAS  Google Scholar 

  23. Summary of product characteristics: Sulthiame (Ospolot). Phebra Pty, Ltd. Last update 21 Nov 2013.

    Google Scholar 

  24. Doose DR, Walker SA, Pledger G, Lim P, Reife RA. Evaluation of phenobarbital and primidone/phenobarbital (primidone active metabolite) plasma concentrations during administration of add-on topiramate therapy in five multicenter, double-blind, placebo controlled trials in outpatients with partial seizures. Epilepsia. 1995;36(Suppl 3):158.

    Google Scholar 

  25. Kapetanovic IM, Kupferberg HJ, Porter RJ, Theodore W, Schulman E, Penry JK. Mechanism of valproate–phenobarbital interaction in epileptic patients. Clin Pharmacol Ther. 1981;29:480–6.

    Article  CAS  Google Scholar 

  26. Loiseau P, Hardenberg JP, Pestre M, Guyot M, Schechter PJ, Tell GP. Double-blind, placebo-controlled study of vigabatrin (gamma-vinyl GABA) in drug-resistant epilepsy. Epilepsia. 1986;27:115–20.

    Article  CAS  Google Scholar 

  27. Spence SJ, Nakagawa J, Sankar R, Shields WD. Phenobarbital interferes with the efficacy of vigabatrin in treating infantile spasms in patients with tuberous sclerosis. Epilepsia. 2000;41(Suppl 7):189.

    Google Scholar 

  28. Buchanan RA, Page JG, French JA, Leppik IE, Padgett CS. Zonisamide drug interactions. Epilepsia. 1997;38(Suppl 8):107.

    Google Scholar 

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Authors and Affiliations

  1. Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK

    Philip N. Patsalos

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  1. Philip N. Patsalos
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Correspondence to Philip N. Patsalos .

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Patsalos, P.N. (2022). Phenobarbital. In: Antiseizure Medication Interactions. Springer, Cham. https://doi.org/10.1007/978-3-030-82790-8_21

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  • DOI: https://doi.org/10.1007/978-3-030-82790-8_21

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-82789-2

  • Online ISBN: 978-3-030-82790-8

  • eBook Packages: MedicineMedicine (R0)

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