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Decellularization of Bone Tissue

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Decellularization Methods of Tissue and Whole Organ in Tissue Engineering

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1345))

Abstract

Decellularization technology is a process that uses different methods such as physical, chemical or enzymatic methods in order to eliminate cellular remnants from original tissues or organs while minimizing any adverse effect on the structural properties, biological activity, and mechanical integrity of the remaining ECM. Regenerative medicine uses the most promising therapies to replace or regenerate tissues and organs in human, restore or establish normal functions lost due to disease or injury. By the combination between new biomaterials and cells, one of the goals of regenerative medicine is to create autologous grafts for transplantation therapies in the future.

Various decellularization methods have been developed include chemical treatment, biological treatment and physical treatment. The aim of this chapter is to evaluate the decellularization method and all available materials that preserves the matrix without structural disruption.

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Authors and Affiliations

  1. Laboratory of Tissue Engineering and Biomedical Materials, Department of Physiology and Animal Biotechnology, Faculty of Biology – Biotechnology, University of Science, Vietnam National University, Ho Chi Minh City (VNU-HCM), Ho Chi Minh City, Vietnam

    Ha Le Bao Tran, Vu Nguyen Doan, Quan Minh To, My Thi Ngoc Nguyen, Van Ngoc Le Trinh & Tuyet Thi Vi Le

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  2. Vu Nguyen Doan
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  1. Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

    Abdol-Mohammad Kajbafzadeh

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Tran, H.L.B., Doan, V.N., To, Q.M., Nguyen, M.T.N., Trinh, V.N.L., Le, T.T.V. (2021). Decellularization of Bone Tissue. In: Kajbafzadeh, AM. (eds) Decellularization Methods of Tissue and Whole Organ in Tissue Engineering. Advances in Experimental Medicine and Biology, vol 1345. Springer, Cham. https://doi.org/10.1007/978-3-030-82735-9_18

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