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Quality of Life in Celiac Disease

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Advances in Celiac Disease

Abstract

Celiac disease (CD) is a systemic immune disorder whose only treatment is a gluten-free diet (GFD). Its chronic nature, together with the restrictions imposed by the restrictive and permanent diet, can have a considerable negative impact on the health-related quality of life (HRQoL) of CD patients and their families. To objectively assess HRQoL, validated questionnaires should be used. In this chapter, studies performed using validated generic and specific questionnaires have been reviewed. Most studies show that before starting the GFD, recently diagnosed children and adult CD patients have a worse HRQoL than the general population, although, after one year of treatment with a GFD, their HRQoL is similar to that of the general population. However, adults’ HRQoL is not completely normalized, probably due to the social and emotional effects of following a strict diet. Children score their general HRQoL as “good” when it is assessed with different generic questionnaires and the specific CDPQOL, whereas they consider as “neutral” when it is assessed using the specific CDDUX. When children’s and parents’ opinion are assessed, in general parents evaluate their children´s HRQoL worse than the children themselves. As a result, in the opinion of most authors, it is interesting to assess both point of views. In children and adults, the main factors related to having a worse HRQoL are dietary non-adherence and having social and/or economic difficulties, related to following the GFD. In summary, adult celiac patients and both, celiac children and their parents, feel that the disease have no substantial negative impacts on patients’ HRQOL.

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Abbreviations

CD:

Celiac disease

GFD:

Gluten -free diet

HRQoL:

Health Related Quality of Life

QoL:

Quality of Life

WHO:

World Health Organization

SF-36:

Short Form 36-Item Health Survey

EuroQoL-5D (EQ_5D):

European Quality of Life-5 Dimensions visual analogic scale

PGWB:

Psychological General well-being Index

CDQ:

Celiac Disease Questionnaire

CD_QOL:

Celiac Quality of Life Survey

PedsQL:

Paediatric Quality of Life Inventory

KIDSCREEN-52:

Generic KIDSCREEN questionnaire which consists of 52 items

DISABKIDS:

Quality Of Life generic questionnaire to evaluate HRQoL in children and adolescents with DISABilities and their families

CDDUX:

Celiac Disease DUX

CDPQOL:

Celiac Disease Paediatric Quality of life

SF-12:

Short-Form 12-Item Health Survey

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Authors and Affiliations

  1. Department of Paediatrics, Hospital Universitario de Fuenlabrada, Madrid, Spain

    Josefa Barrio

  2. Department of Paediatrics, Hospital Universitario Puerta Hierro, Madrid, Spain

    María Luz Cilleruelo

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  1. Josefa Barrio
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Editors and Affiliations

  1. Department of Pediatrics, São João University Hospital, Porto, Portugal

    Jorge Amil-Dias

  2. Department of Pediatrics, Autonoma University , Madrid, Spain

    Isabel Polanco

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Barrio, J., Cilleruelo, M.L. (2022). Quality of Life in Celiac Disease. In: Amil-Dias, J., Polanco, I. (eds) Advances in Celiac Disease . Springer, Cham. https://doi.org/10.1007/978-3-030-82401-3_14

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