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Celiac Disease Prevention

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Advances in Celiac Disease

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Abstract

Only a minority of the 40% of the Caucasian population that has a genetic predisposition for celiac disease develops it. Environmental and/or lifestyle factors may play a causal role in the development of the disease and their identification may allow its primary prevention. Early infant feeding practices have been prospectively studied in this respect and it has been shown that neither the timing of gluten introduction nor the duration or maintenance of breastfeeding influence the risk of celiac disease. Other environmental factors not related to the disease development are the type of delivery and the exposure to antibiotics in early life. Recent studies in birth cohorts suggest that the quantity of gluten consumed early in life, especially if accompanied by viral infections, as well as the type of diet after weaning, may be preventable risk factors for celiac disease development, but randomized controlled intervention trials are needed. The role of the gut microbiome is being extensively studied, but at this moment no causal role has been found and the results of prospective studies are expected.

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Authors and Affiliations

  1. Department of Pediatrics, Leiden University Medical Center, Willem Alexander Children’s Hospital, Leiden, Netherlands

    M. Luisa Mearin

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Correspondence to M. Luisa Mearin .

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  1. Department of Pediatrics, São João University Hospital, Porto, Portugal

    Jorge Amil-Dias

  2. Department of Pediatrics, Autonoma University , Madrid, Spain

    Isabel Polanco

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Mearin, M.L. (2022). Celiac Disease Prevention. In: Amil-Dias, J., Polanco, I. (eds) Advances in Celiac Disease . Springer, Cham. https://doi.org/10.1007/978-3-030-82401-3_11

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  • DOI: https://doi.org/10.1007/978-3-030-82401-3_11

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