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Gallbladder Disease

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Pediatric Surgery

Abstract

Gallbladder disease is one of the most common abdominal conditions requiring the attention of the pediatric surgeon. In this chapter, we review the etiology of stone disease and types of presentation from inflammatory conditions of the gallbladder and biliary tree. We outline the phenomenon of biliary disease and explore the diagnostic algorithms for patients with biliary symptoms. In addition, we compare the treatment options and examine the published outcomes to date.

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References

  • Agarwal N, Sharma BC, Garg S et al (2006) Endoscopic management of postoperative bile leaks. Hepatobiliary Pancreat Dis Int 5:273–277

    PubMed  Google Scholar 

  • Bhattacharyya N et al (1993) Perioperative management for cholecystectomy in sickle cell disease. J Pediatr Surg 28:72–75

    CAS  PubMed  Google Scholar 

  • Carney DE, Evan R, Kokoska ER et al (2004) Predictors of successful outcome after cholecystectomy for biliary dyskinesia. J Pediatr Surg 39:813–816

    PubMed  Google Scholar 

  • Cooperberg PL, Burhenne HJ (1980) Real-time ultrasonography. Diagnostic technique of choice in calculous gallbladder disease. N Engl J Med 302:1277–1279

    CAS  PubMed  Google Scholar 

  • Cuschieri A, Lezoche E, Morino M et al (1999) E.a.E.S. multicenter prospective randomized trial comparing two-stage vs. single-stage management of patients with gallstone disease and ductal calculi. Surg Endosc 29:952–957

    Google Scholar 

  • Dalton BG, Gonzalez KW, Knott EM et al (2015) Same day discharge after laparoscopic cholecystectomy in children. J Surg Res 195:418–412

    PubMed  Google Scholar 

  • Dekonenko C, Sujka JA, Dorman RM, Oyetunji TA, St Peter SD (2019 Sep) Self-reported outcomes after cholecystectomy for pediatric hyperkinetic biliary dyskinesia. J Surg Res 25(246):73–77

    Google Scholar 

  • Dolan JP, Diggs BS, Sheppard BC et al (2005) Ten-year trend in the national volume of bile duct injuries requiring operative repair. Surg Endosc 19:967–993

    CAS  PubMed  Google Scholar 

  • Dubois F, Berthelot G, Levard H (1989) Cholecystectomy by coelioscopy. Presse Med 18:980–982

    CAS  PubMed  Google Scholar 

  • Friesen CA, Neilan N, Daniel JF et al (2011) Mast cell activation and clinical outcome in pediatric cholelithiasis and biliary dyskinesia. BMC Res Notes 4:322

    PubMed  PubMed Central  Google Scholar 

  • Garey CL, Laituri CA, Ostlie DJ, Snyder CL, Andrews WS, Holcomb GW 3rd, St Peter SD (2011 May) Single-incision laparoscopic surgery in children: initial single-center experience. J Pediatr Surg 46(5):904–907

    PubMed  Google Scholar 

  • Gasior AC, Knott EM, Holcomb GW 3rd, Ostlie DJ, St Peter SD (2014 Jan) Patient and parental scar assessment after single incision versus standard 3-port laparoscopic appendectomy: Long-term follow-up from a prospective randomized trial. J Pediatr Surg 49(1):120–122

    PubMed  Google Scholar 

  • Goodwin EF, Partain PI, Lebensburger JD et al (2017) Elective cholecystectomy reduces morbidity of cholelithiasis in pediatric sickle cell disease. Pediatr Blood Cancer 64:113–120

    PubMed  Google Scholar 

  • Gould JL, Poola AS, St Peter SD et al (2016) Same day discharge protocol implementation trends in laparoscopic cholecystectomy in pediatric patients. J Pediatr Surg 51:1936–1938

    PubMed  Google Scholar 

  • Gurusamy KS, Vaughan J, Rossi M, Davidson BR (2014, Feb 20) Fewer-than-four ports versus four ports for laparoscopic cholecystectomy Cochrane Database Syst Rev (2):CD007109

    Google Scholar 

  • Haberkern CM, Neumayr LD, Orringer EP et al (1997) Cholecystectomy in sickle cell anemia patients: perioperative outcome of 364 cases from the national preoperative transfusion study. Preoperative transfusion in sickle cell disease study group. Blood 89:1533–1542

    CAS  PubMed  Google Scholar 

  • Holcomb GW III (1993) Laparoscopic cholecystectomy. Semin Pediatr Surg 2:159–167

    PubMed  Google Scholar 

  • Holcomb GW III, Sharp KW, Olsen DO (1991) Laparoscopic cholecystectomy in the pediatric patient. J Pediatr Surg 26:1186–1190

    PubMed  Google Scholar 

  • Holcomb GW III, Morgan WM III, Neblett WW III et al (1999) Laparoscopic cholecystectomy in children: lessons learned from the first 100 patients. J Pediatr Surg 34:1236–1240

    PubMed  Google Scholar 

  • Holcomb GW Jr, O’Neill JA Jr, Holcomb GW III (1980) Cholecystitis, cholelithiasis and common duct stenosis in children and adolescents. Ann Surg 191:626–635

    PubMed  PubMed Central  Google Scholar 

  • Kaechele V, Wabitsch M, Thiere D et al (2006) Prevalence of gallbladder stone disease in obese children and adolescents: influence of the degree of obesity, sex, and pubertal development. J Pediatr Gastroenterol Nutr 42:66–70

    PubMed  Google Scholar 

  • Khoo AK, Cartwright R, Berry S et al (2014) Cholecystectomy in English children: evidence of an epidemic (1997-2012). J Pediatr Surg 49:284–288

    PubMed  Google Scholar 

  • King DR, Ginn-Pease ME, Lloyd TV et al (1987) Parenteral nutrition with associated cholelithiasis: another iatrogenic disease of infants and children. J Pediatr Surg 22:593–596

    CAS  PubMed  Google Scholar 

  • Knott EM, Fike FB, Gasior AC, Cusick R, Brownie E, St Peter SD, Azarow KS (2013 Dec) Multi-institutional analysis of long-term symptom resolution after cholecystectomy for biliary dyskinesia in children. Pediatr Surg Int 29(12):1243–1247

    PubMed  Google Scholar 

  • Lacher M, Yannam GR, Muensterer OJ et al (2013) Laparoscopic cholecystectomy for biliary dyskinesia in children: frequency increasing. J Pediatr Surg 48:1716–1721

    PubMed  Google Scholar 

  • Lachman BS, Lazerson J, Starshak RJ et al (1979) The prevalence of cholelithiasis in sickle cell disease as diagnosed by ultrasound and cholecystography. Pediatrics 64:601–603

    CAS  PubMed  Google Scholar 

  • Lai SW, Rothenberg SS, Kay SM et al (2017) Outcomes of laparoscopic cholecystectomy for biliary dyskinesia in children. J Laparoendosc Adv Surg Tech A 27:845–850

    PubMed  Google Scholar 

  • Liem NT, Benedict LA, Holcomb GW III (2020) Choldedochal cyst and gallbladder disease. In: Holcomb and Ashcraft’s pediatric surgery, 7th edn. Elsevier Inc., St. Louis, pp 695–708

    Google Scholar 

  • Lillemoe KD (2006) Evaluation of suspected bile duct injuries. Surg Endosc 20:1638–1643

    CAS  PubMed  Google Scholar 

  • Lillemoe KD, Melton GB, Cameron JL et al (2000) Postoperative bile duct strictures: management and outcome in the 1990s. Ann Surg 232:430–441

    CAS  PubMed  PubMed Central  Google Scholar 

  • Mah D, Wales P, Njere I et al (2004) Management of suspected common bile duct stones in children: role of selective intraoperative cholangiogram and endoscopic retrograde cholangiopancreatography. J Pediatr Surg 39:808–812

    PubMed  Google Scholar 

  • Matos C, Avni EF, VanGansbeke D et al (1987) Total parenteral nutrition (TPN) and gallbladder diseases in neonates. J Ultrasound Med 6:243–248

    CAS  PubMed  Google Scholar 

  • McChesney JA, Northup PG, Bickston SJ (2003) Acute acalculous cholecystitis associated with systemic sepsis and visceral arterial hypoperfusion: a case series and review of pathophysiology. Dig Dis Sci 48:1960–1967

    PubMed  Google Scholar 

  • McKernan JB (1991) Laparoscopic cholecystectomy. Am Surg 57:309–312

    CAS  PubMed  Google Scholar 

  • McLean TR (2006) Risk management observations from litigation involving laparoscopic cholecystectomy. Arch Surg 141:643–648

    PubMed  Google Scholar 

  • Moody FG, Haley-Russell D, Li YF et al (1989) The effects of lithogenic bile on gallbladder epithelium. Ann Surg 210:406–415

    CAS  PubMed  PubMed Central  Google Scholar 

  • Newman KD, Powell DM, Holcomb GW III (1997) The management of choledocholithiasis in children in the era of laparoscopic cholecystectomy. J Pediatr Surg 32:1116–1119

    CAS  PubMed  Google Scholar 

  • Ostlie DJ, Holcomb GW III (2003) The use of stab incisions for instrument access in laparoscopic operations. J Pediatr Surg 38:1837–1840

    PubMed  Google Scholar 

  • Ostlie DJ, Juang OO, Iqbal CW et al (2013) Single incision versus standard 4-port laparoscopic cholecystectomy: a prospective randomized trial. J Pediatr Surg 48:209–214

    PubMed  Google Scholar 

  • Rau B, Friesen CA, Daniel JF et al (2006) Gallbladder wall inflammatory cells in pediatric patients with biliary dyskinesia and cholelithiasis: a pilot study. J Pediatr Surg 41:1545–1548

    PubMed  Google Scholar 

  • Reddick EJ, Olsen DO (1989) Laparoscopic laser cholecystectomy. A comparison with mini-lap cholecystectomy. Surg Endosc 3:131–113

    CAS  PubMed  Google Scholar 

  • Reynolds W Jr (2001) The first laparoscopic cholecystectomy. JSLS 5:89–94

    PubMed  PubMed Central  Google Scholar 

  • Rhodes MM, Bates DG, Andrews T et al (2014) Abdominal pain in children with sickle cell disease. J Clin Gastroenterol 48:99–105

    PubMed  Google Scholar 

  • Sandler A, Winkel G, Kimura K et al (1999) The role of prophylactic cholecystectomy during splenectomy in children with hereditary spherocytosis. J Pediatr Surg 34:1077–1078

    CAS  PubMed  Google Scholar 

  • Sandoval C, Stringel G, Ozkaynak MF et al (2002) Perioperative management of children with sickle cell disease undergoing laparoscopic surgery. JSLS 6:29–33

    PubMed  PubMed Central  Google Scholar 

  • Schweizer P, Lenz MP, Kirschner HJ (2000) Pathogenesis and symptomatology of cholelithiasis in childhood. A prospective study. Dig Surg 17:459–467

    CAS  PubMed  Google Scholar 

  • Srinath AI, Youk AO, Bielefeldt K (2014) Biliary dyskinesia and symptomatic gallstone disease in children: two sides of the same coin? Dig Dis Sci 59:1307–1315

    PubMed  PubMed Central  Google Scholar 

  • St Peter SD, Keckler SJ, Nair A, Andrews WS, Sharp RJ, Snyder CL, Ostlie DJ, Holcomb GW (2008 Feb) Laparoscopic cholecystectomy in the pediatric population. J Laparoendosc Adv Surg Tech A 18(1):127–130

    PubMed  Google Scholar 

  • Strasberg SM, Brunt LM (2010) Rationale and use of the critical view of safety in laparoscopic cholecystectomy. J Am Coll Surg 211:132–138

    PubMed  Google Scholar 

  • Strasberg SM, Hertl M, Soper NJ (1995) An analysis of the problem of biliary injury during laparoscopic cholecystectomy. J Am Coll Surg 180:101–125

    CAS  PubMed  Google Scholar 

  • Stringer MD, Ceylan H, Ward K et al (2003) Gallbladder polyps in children – classification and management. J Pediatr Surg 38:1680–1684

    PubMed  Google Scholar 

  • St-Vil D, Yazbeck S, Luks FL et al (1992) Cholelithiasis in newborns and infants. J Pediatr Surg 27:1305–1307

    CAS  PubMed  Google Scholar 

  • Tsai J, Sulkowski JP, Cooper JN et al (2013) Sensitivity and predictive value of ultrasound in pediatric cholecystitis. J Surg Res 184:378–382

    PubMed  Google Scholar 

  • Vaughan J, Nagendran M, Cooper J, Davidson BR, Gurusamy KS (2014 Jan 24) Anaesthetic regimens for day-procedure laparoscopic cholecystectomy. Cochrane Database Syst Rev (1):CD009784

    Google Scholar 

  • Vettoretto N, Saronni C, Harbi A et al (2011) Critical view of safety during laparoscopic cholecystectomy. JSLS 15:322–325

    PubMed  PubMed Central  Google Scholar 

  • Wales PW, Carver E, Crawford MW et al (2001) Acute chest syndrome after abdominal surgery in children with sickle cell disease: is a laparoscopic approach better? J Pediatr Surg 36:718–721

    CAS  PubMed  Google Scholar 

  • Walker SK, Maki AC, Cannon RM et al (2013) Etiology and incidence of pediatric gallbladder disease. Surgery 154:927–933

    PubMed  Google Scholar 

  • Wu SC, Chen FC, Lo CJ (2005) Selective intraoperative cholangiography and single-stage management of common bile duct stone in laparoscopic cholecystectomy. World J Surg 29:1402–1408

    PubMed  Google Scholar 

  • Zargar SA, Javid G, Khan BA et al (2003) Endoscopic sphincterotomy in the management of bile duct stones in children. Am J Gastroenterol 98:586–589

    PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Children’s Mercy Hospital, Kansas City, MO, USA

    Charlene Dekonenko, Shawn D. St. Peter & George W. Holcomb III

Authors
  1. Charlene Dekonenko
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  2. Shawn D. St. Peter
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  3. George W. Holcomb III
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Corresponding author

Correspondence to George W. Holcomb III .

Editor information

Editors and Affiliations

  1. Beacon Hospital, University College Dublin, Dublin, Ireland

    Prem Puri

  2. University Clinic of Paediatric and Adolescent Surgery, Medical University of Graz, Graz, Austria

    Michael E. Höllwarth

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Dekonenko, C., St. Peter, S.D., Holcomb, G.W. (2023). Gallbladder Disease. In: Puri, P., Höllwarth, M.E. (eds) Pediatric Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-81488-5_83

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  • DOI: https://doi.org/10.1007/978-3-030-81488-5_83

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-81487-8

  • Online ISBN: 978-3-030-81488-5

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