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2-[18F]FDG PET/CT in Fever of Unknown Origin

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Nuclear Medicine and Immunology

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Abstract

Fever of unknown origin (FUO) is characterized as fever of greater than 38.3 °C on several occasions during at least 3 weeks with indeterminate diagnosis after a number of required investigations. It is of utmost importance to search for potential diagnostic clues in a thorough history taking, physical examination, and the crucial investigations in order to diagnose FUO. In the absence of diagnostic clues, whole-body imaging should be considered to direct additional diagnostic tests. 2-[18F]FDG positron emission tomography/computed tomography (PET/CT) is a sensitive diagnostic modality for the assessment of FUO by enabling anatomical localization of focally increased 2-[18F]FDG uptake, thus directing further diagnostic tests to achieve a final diagnosis. 2-[18F]FDG PET/CT has some important advantages compared to conventional radiological imaging and has shown to be cost-effective in patients with FUO. This chapter provides an overview of 2-[18F]FDG PET/CT in FUO diagnosis.

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Author information

Authors and Affiliations

  1. Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands

    Ilse J. E. Kouijzer & Chantal P. Bleeker-Rovers

  2. Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands

    Lioe-Fee de Geus-Oei

Authors
  1. Ilse J. E. Kouijzer
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  2. Chantal P. Bleeker-Rovers
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  3. Lioe-Fee de Geus-Oei
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Corresponding author

Correspondence to Ilse J. E. Kouijzer .

Editor information

Editors and Affiliations

  1. Department of Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Sara Harsini

  2. Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA

    Abass Alavi

  3. Research Center for Immunodeficiencies, Tehran University of Medical Sciences, Tehran, Iran

    Nima Rezaei

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Kouijzer, I.J.E., Bleeker-Rovers, C.P., de Geus-Oei, LF. (2022). 2-[18F]FDG PET/CT in Fever of Unknown Origin. In: Harsini, S., Alavi, A., Rezaei, N. (eds) Nuclear Medicine and Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-81261-4_8

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  • DOI: https://doi.org/10.1007/978-3-030-81261-4_8

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-81260-7

  • Online ISBN: 978-3-030-81261-4

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