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Klinefelter Syndrome and Eating and Weight Disorders

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Hidden and Lesser-known Disordered Eating Behaviors in Medical and Psychiatric Conditions

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Abstract

Klinefelter syndrome is the most common sex chromosome disorder in males, with an estimated prevalence of 1 case per 660 newborns, characterized by: hypergonadotropic hypogonadism with tall stature; small and firm testes; gynecomastia; large hips; scanty body hair. Other clinical aspects may also characterize the syndrome, including a tendency for visceral obesity, dyslipidemia, hypertension and diabetes mellitus, and hence metabolic syndrome and psychiatric disorders, including depression and schizophrenia. The extra X chromosome has a role in fat storage and hence in weight and body composition variations. The gonadal hormones play a role in regulating fat storage, affecting processes from food intake and adipocyte differentiation to energy expenditure.

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Authors and Affiliations

  1. Centre for Rare Diseases, Policlinico Umberto I, Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Rome, Italy

    Antonio F. Radicioni & Matteo Spaziani

Authors
  1. Antonio F. Radicioni
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  2. Matteo Spaziani
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Corresponding author

Correspondence to Antonio F. Radicioni .

Editor information

Editors and Affiliations

  1. Private Hospital "Salus" of Ferrara, University of Ferrara, Ferrara, Italy

    Emilia Manzato

  2. Formerly Sapienza University of Rome, Founding Editor of Eating and Weight Disorders, Campiglia Marittima, Livorno, Italy

    Massimo Cuzzolaro

  3. Experimental Medicine Department, Sapienza University of Rome, Editor-in-Chief of Eating and Weight Disorders, Roma, Roma, Italy

    Lorenzo Maria Donini

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Radicioni, A.F., Spaziani, M. (2022). Klinefelter Syndrome and Eating and Weight Disorders. In: Manzato, E., Cuzzolaro, M., Donini, L.M. (eds) Hidden and Lesser-known Disordered Eating Behaviors in Medical and Psychiatric Conditions . Springer, Cham. https://doi.org/10.1007/978-3-030-81174-7_30

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  • DOI: https://doi.org/10.1007/978-3-030-81174-7_30

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-81173-0

  • Online ISBN: 978-3-030-81174-7

  • eBook Packages: MedicineMedicine (R0)

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