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Kleine–Levin Syndrome and Eating and Weight Disorders

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Hidden and Lesser-known Disordered Eating Behaviors in Medical and Psychiatric Conditions

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Abstract

Kleine-Levin syndrome (KLS) is a rare neuropsychiatric disorder with a relapsing-remitting course characterized by recurrent episodes of hypersomnia and cognitive and behavioral changes. The pathogenesis is unknown, but it may involve a dysfunction of the mesencephalic-hypothalamic-limbic system. The prevalence of syndrome is estimated to be 1–5 per million with a male/female ratio of 3:1. The typical triad of symptoms is sleep disorder, hyperphagia, and behavioral disorders, especially hypersexuality (above all in males). Between episodes there are long asymptomatic periods of normal sleep, cognition, mood, and behavior.

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References

  1. Kleine W. Periodische Schlafsucht. Eur Neurol. 1925:285–304. https://doi.org/10.1159/000190426.

  2. Levin M. Periodic somnolence and morbid hunger: a new syndrome. Brain. 1936; https://doi.org/10.1093/brain/59.4.494.

  3. Critchley M. Periodic hypersomnia and megaphagia in adolescent males. Brain. 1962; https://doi.org/10.1093/brain/85.4.627.

  4. Arnulf I, Lin L, Gadoth N, et al. Kleine-Levin syndrome: a systematic study of 108 patients. Ann Neurol. 2008; https://doi.org/10.1002/ana.21333.

  5. Huang Y-S, Guilleminault C, Lin K-L, Hwang F-M, Liu F-Y, Kung Y-P. Relationship between Kleine-Levin syndrome and upper respiratory infection in Taiwan. Sleep. 2012; https://doi.org/10.5665/sleep.1600.

  6. Arnulf I, Lecendreux M, Franco P, Dauvilliers Y. Kleine-Levin syndrome: state of the art. Rev Neurol (Paris). 2008; https://doi.org/10.1016/j.neurol.2008.04.020.

  7. Arnulf I, Zeitzer JM, File J, Farber N, Mignot E. Kleine-Levin syndrome: a systematic review of 186 cases in the literature. Brain. 2005; https://doi.org/10.1093/brain/awh620.

  8. Peraita-Adrados R, Vicario JL, Tafti M, García de León M, Billiard M. Monozygotic twins affected with Kleine-Levin syndrome. Sleep. 2012; https://doi.org/10.5665/sleep.1808.

  9. Sateia MJ. International classification of sleep disorders-third edition highlights and modifications. Chest. 2014; https://doi.org/10.1378/chest.14-0970.

  10. Miglis MG, Guilleminault C. Kleine-Levin syndrome. Curr Neurol Neurosci Rep. 2016; https://doi.org/10.1007/s11910-016-0653-6.

  11. Aasm. International classification of sleep disorders: diagnostic and coding manual. (ICSD-2).; 2005.

    Google Scholar 

  12. Arnulf I, Rico TJ, Mignot E. Diagnosis, disease course, and management of patients with Kleine-Levin syndrome. Lancet Neurol. 2012; https://doi.org/10.1016/S1474-4422(12)70187-4.

  13. Arnulf I, Groos E, Dodet P. Kleine–Levin syndrome: a neuropsychiatric disorder. Rev Neurol (Paris). 2018; https://doi.org/10.1016/j.neurol.2018.03.005.

  14. Duffy JP, Davison K. A female case of the Kleine-Levin syndrome. Br J Psychiatry. 1968; https://doi.org/10.1192/bjp.114.506.77.

  15. Schenck CH, Amulf I, Mahowald MW. Sleep and sex: What can go wrong? A review of the literature on sleep related disorders and abnormal sexual behaviors and experiences. Sleep. 2007; https://doi.org/10.1093/sleep/30.6.683.

  16. Engström M, Vigren P, Karlsson T, Landtblom AM. Working memory in 8 Kleine-Levin syndrome patients: an fMRI study. Sleep. 2009; https://doi.org/10.1093/sleep/32.5.681.

  17. Abe K. Lithium prophylaxis of periodic hypersomnia. Br J Psychiatry. 1977; https://doi.org/10.1192/bjp.130.3.312.

  18. de Oliveira MM, Conti C, Prado GF. Pharmacological treatment for Kleine-Levin syndrome. Cochrane Database Syst Rev. 2016; https://doi.org/10.1002/14651858.CD006685.pub4.

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Authors and Affiliations

  1. Centre for Rare Diseases, Policlinico Umberto I, Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Rome, Italy

    Antonio F. Radicioni, Chiara Tarantino & Matteo Spaziani

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  1. Antonio F. Radicioni
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  2. Chiara Tarantino
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  3. Matteo Spaziani
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Correspondence to Antonio F. Radicioni .

Editor information

Editors and Affiliations

  1. Private Hospital "Salus" of Ferrara, University of Ferrara, Ferrara, Italy

    Emilia Manzato

  2. Formerly Sapienza University of Rome, Founding Editor of Eating and Weight Disorders, Campiglia Marittima, Livorno, Italy

    Massimo Cuzzolaro

  3. Experimental Medicine Department, Sapienza University of Rome, Editor-in-Chief of Eating and Weight Disorders, Roma, Roma, Italy

    Lorenzo Maria Donini

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Radicioni, A.F., Tarantino, C., Spaziani, M. (2022). Kleine–Levin Syndrome and Eating and Weight Disorders. In: Manzato, E., Cuzzolaro, M., Donini, L.M. (eds) Hidden and Lesser-known Disordered Eating Behaviors in Medical and Psychiatric Conditions . Springer, Cham. https://doi.org/10.1007/978-3-030-81174-7_29

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  • DOI: https://doi.org/10.1007/978-3-030-81174-7_29

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-81173-0

  • Online ISBN: 978-3-030-81174-7

  • eBook Packages: MedicineMedicine (R0)

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