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Circadian Clocks, Sleep, and Metabolism

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Circadian Clock in Brain Health and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1344))

Abstract

A molecular circadian clock exists not only in the brain, but also in most cells of the body. Research over the past two decades has demonstrated that it directs daily rhythmicity of nearly every aspect of metabolism. It also consolidates sleep-wake behavior each day into an activity/feeding period and a sleep/fasting period. Otherwise, sleep-wake states are mostly controlled by hypothalamic and thalamic regulatory circuits in the brain that direct overall brain state. Recent evidence suggests that hypothalamic control of appetite and metabolism may be concomitant with sleep-wake regulation, and even share the same control centers. Thus, circadian control of metabolic pathways might be overlaid by sleep-wake control of the same pathways, providing a flexible and redundant system to modify metabolism according to both activity and environment.

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  1. Nora Nowak and Audrey Rawleigh contributed equally with all other contributors.

Authors and Affiliations

  1. ETH Zurich, Department of Chemistry and Applied Biosciences, Zurich, Switzerland

    Nora Nowak

  2. University of Zurich, Institute of Pharmacology and Toxicology, Zurich, Switzerland

    Nora Nowak, Audrey Rawleigh & Steven A. Brown

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  1. Institute of Human Genetics University Hospital Jena Friedrich Schiller University, Jena, Germany

    Olivia Engmann

  2. UK Dementia Research Institute, Imperial College London, London, UK

    Marco Brancaccio

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Nowak, N., Rawleigh, A., Brown, S.A. (2021). Circadian Clocks, Sleep, and Metabolism. In: Engmann, O., Brancaccio, M. (eds) Circadian Clock in Brain Health and Disease. Advances in Experimental Medicine and Biology, vol 1344. Springer, Cham. https://doi.org/10.1007/978-3-030-81147-1_2

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