Skip to main content

Calcium Silicate-Based Cement (Biodentine™) as a Bioactive Material for the Long-Term Preservation of Pulp Vitality in Restorative Dentistry and Prosthodontics

  • Chapter
  • First Online:
Biodentine™

Abstract

Preservation of pulp vitality in cases of deep carious lesions or pulp exposure after mechanical trauma is a critical factor determining the prognosis of teeth after restorative treatment. Although Biodentine has demonstrated a successful outcome when used for direct or indirect pulp capping (DPC/IPC), data on its potential application as a core buildup material underneath prosthetic restorations are completely lacking.

In this chapter, a literature survey of the electronic database on clinical studies on humans published between 2015 and 2020 is presented. Biodentine use in IPC was reported in four studies, with 80% of treated teeth maintaining their vitality after 12 months. Its application in DPC was reported in nine studies and showed 86% success after 3 years.

This chapter highlights the factors providing evidence for the application of Biodentine as core buildup material which include its enhanced mechanical and handling properties, good sealing ability, and development of a firm bond with the underlying dentin substrate. It is highly indicated for teeth of younger patients with mild symptoms of reversible pulpitis following a strict IPC or DPC aseptic protocol.

Clinical cases demonstrating successful application of Biodentine in deep carious lesions in abutment teeth covered with indirect restorations or full-coverage crowns are also presented.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Pjetursson BE, Sailer I, Makarov NA, Zwahlen M, Thoma DS. All-ceramic or metal-ceramic tooth-supported fixed dental prostheses (FDPs)? A systematic review of the survival and complication rates. Part II: multiple-unit FDPs. Dent Mater. 2015;31(6):624–39. https://doi.org/10.1016/j.dental.2015.02.013.

    Article  PubMed  Google Scholar 

  2. De Backer H, Van Maele G, De Moor N, Van den Berghe L. Long-term results of short-span versus long-span fixed dental prostheses: an up to 20-year retrospective study. Int J Prosthodont. 2008;21(1):75–85.

    PubMed  Google Scholar 

  3. Fransson H. On the repair of the dentine barrier. Swed Dent J Suppl. 2012;226:9–84.

    Google Scholar 

  4. Stober T, Rammelsberg P. The failure rate of adhesively retained composite core build-ups in comparison with metal-added glass ionomer core build-ups. J Dent. 2005;33(1):27–32. https://doi.org/10.1016/j.jdent.2004.07.006.

    Article  PubMed  Google Scholar 

  5. Theodosopoulou JN, Chochlidakis KM. A systematic review of dowel (post) and core materials and systems. J Prosthodont. 2009;18(6):464–72. https://doi.org/10.1111/j.1532-849X.2009.00472.x.

    Article  PubMed  Google Scholar 

  6. Tsiagali V, Kirmanidou Y, Pissiotis A, Michalakis K. In vitro assessment of retention and resistance failure loads of teeth restored with a complete coverage restoration and different core materials. J Prosthodont. 2019;28(1):e229–36. https://doi.org/10.1111/jopr.12668.

    Article  PubMed  Google Scholar 

  7. Hilton TJ. Keys to clinical success with pulp capping: a review of the literature. Oper Dent. 2009;34(5):615–25. https://doi.org/10.2341/09-132-0.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Dammaschke T, Leidinger J, Schäfer E. Long-term evaluation of direct pulp capping—treatment outcomes over an average period of 6.1 years. Clin Oral Investig. 2010;14(5):559–67. https://doi.org/10.1007/s00784-009-0326-9.

    Article  PubMed  Google Scholar 

  9. Al-Hiyasat AS, Barrieshi-Nusair KM, Al-Omari MA. The radiographic outcomes of direct pulp-capping procedures performed by dental students: a retrospective study. J Am Dent Assoc. 2006;137(12):1699–705. https://doi.org/10.14219/jada.archive.2006.0116.

    Article  PubMed  Google Scholar 

  10. Mohammadi Z, Dummer PM. Properties and applications of calcium hydroxide in endodontics and dental traumatology. Int Endod J. 2011;44(8):697–730. https://doi.org/10.1111/j.1365-2591.2011.01886.x.

    Article  PubMed  Google Scholar 

  11. Weiner RS, Weiner LK, Kugel G. Teaching the use of bases and liners: a survey of North American dental schools. J Am Dent Assoc. 1996;127(11):1640–5. https://doi.org/10.14219/jada.archive.1996.0100.

    Article  PubMed  Google Scholar 

  12. Kumar G, Shivrayan A. Comparative study of mechanical properties of direct core build-up materials. Contemp Clin Dent. 2015;6(1):16–20. https://doi.org/10.4103/0976-237X.149285.

    Article  PubMed  PubMed Central  Google Scholar 

  13. de Souza Costa CA, Teixeira HM, Lopes do Nascimento AB, Hebling J. Biocompatibility of resin-based dental materials applied as liners in deep cavities prepared in human teeth. J Biomed Mater Res B Appl Biomater. 2007;81(1):175–84. https://doi.org/10.1002/jbm.b.30651.

    Article  PubMed  Google Scholar 

  14. Perdigão J. Current perspectives on dental adhesion: (1) dentin adhesion—not there yet. Jpn Dent Sci Rev. 2020;56(1):190–207. https://doi.org/10.1016/j.jdsr.2020.08.004.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Isolan CP, Sarkis-Onofre R, Lima GS, Moraes RR. Bonding to sound and caries-affected dentin: a systematic review and meta-analysis. J Adhes Dent. 2018;20(1):7–18. https://doi.org/10.3290/j.jad.a39775.

    Article  PubMed  Google Scholar 

  16. Watts DC, Kisumbi BK, Toworfe GK. Dimensional changes of resin/ionomer restoratives in aqueous and neutral media. Dent Mater. 2000;16(2):89–96. https://doi.org/10.1016/s0109-5641(99)00098-6.

    Article  PubMed  Google Scholar 

  17. Paula AB, Laranjo M, Marto CM, Paulo S, Abrantes AM, Casalta-Lopes J, et al. Direct pulp capping: what is the most effective therapy?—systematic review and meta-analysis. J Evid Based Dent Pract. 2018;18(4):298–314. https://doi.org/10.1016/j.jebdp.2018.02.002.

    Article  PubMed  Google Scholar 

  18. Polydorou O, Hammad M, König A, Hellwig E, Kümmerer K. Release of monomers from different core build-up materials. Dent Mater. 2009;25(9):1090–5. https://doi.org/10.1016/j.dental.2009.02.014.

    Article  PubMed  Google Scholar 

  19. Li Z, Cao L, Fan M, Xu Q. Direct pulp capping with calcium hydroxide or mineral trioxide aggregate: a meta-analysis. J Endod. 2015;41(9):1412–7. https://doi.org/10.1016/j.joen.2015.04.012.

    Article  PubMed  Google Scholar 

  20. Cox CF, Sübay RK, Ostro E, Suzuki S, Suzuki SH. Tunnel defects in dentin bridges: their formation following direct pulp capping. Oper Dent. 1996;21(1):4–11.

    PubMed  Google Scholar 

  21. Barczak K, Palczewska-Komsa M, Sikora M, Buczkowska-Radlińska J. Biodentine™—use in dentistry. Literature review. Pomeranian J Life Sci. 2020;66(2):39–45. https://doi.org/10.21164/pomjlifesci.666.

    Article  Google Scholar 

  22. Grech L, Mallia B, Camilleri J. Investigation of the physical properties of tricalcium silicate cement-based root-end filling materials. Dent Mater. 2013;29(2):e20–8. https://doi.org/10.1016/j.dental.2012.11.007.

    Article  PubMed  Google Scholar 

  23. Tran XV, Gorin C, Willig C, Baroukh B, Pellat B, Decup F, et al. Effect of a calcium-silicate-based restorative cement on pulp repair. J Dent Res. 2012;91(12):1166–71. https://doi.org/10.1177/0022034512460833.

    Article  PubMed  Google Scholar 

  24. Koubi G, Colon P, Franquin JC, Hartmann A, Richard G, Faure MO, et al. Clinical evaluation of the performance and safety of a new dentine substitute, Biodentine, in the restoration of posterior teeth—a prospective study. Clin Oral Investig. 2013;17(1):243–9. https://doi.org/10.1007/s00784-012-0701-9.

    Article  PubMed  Google Scholar 

  25. Kayahan MB, Nekoofar MH, McCann A, Sunay H, Kaptan RF, Meraji N, et al. Effect of acid etching procedures on the compressive strength of 4 calcium silicate-based endodontic cements. J Endod. 2013;39(12):1646–8. https://doi.org/10.1016/j.joen.2013.09.008.

    Article  PubMed  Google Scholar 

  26. Odabaş ME, Bani M, Tirali RE. Shear bond strengths of different adhesive systems to Biodentine. ScientificWorldJournal. 2013;2013:626103. https://doi.org/10.1155/2013/626103.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Bachoo IK, Seymour D, Brunton P. A biocompatible and bioactive replacement for dentine: is this a reality? The properties and uses of a novel calcium-based cement. Br Dent J. 2013;214(2):E5. https://doi.org/10.1038/sj.bdj.2013.57.

    Article  PubMed  Google Scholar 

  28. Hashem D, Mannocci F, Patel S, Manoharan A, Watson TF, Banerjee A. Evaluation of the efficacy of calcium silicate vs. glass ionomer cement indirect pulp capping and restoration assessment criteria: a randomised controlled clinical trial-2-year results. Clin Oral Investig. 2019;23(4):1931–9. https://doi.org/10.1007/s00784-018-2638-0.

    Article  PubMed  Google Scholar 

  29. Awawdeh L, Al-Qudah A, Hamouri H, Chakra RJ. Outcomes of vital pulp therapy using mineral trioxide aggregate or Biodentine: a prospective randomized clinical trial. J Endod. 2018;44(11):1603–9. https://doi.org/10.1016/j.joen.2018.08.004.

    Article  PubMed  Google Scholar 

  30. Peskersoy C, Lukarcanin J, Turkun M. Efficacy of different calcium silicate materials as pulp-capping agents: randomized clinical trial. J Dent Sci. 2020; https://doi.org/10.1016/j.jds.2020.08.016.

  31. Lipski M, Nowicka A, Kot K, Postek-Stefańska L, Wysoczańska-Jankowicz I, Borkowski L, et al. Factors affecting the outcomes of direct pulp capping using Biodentine. Clin Oral Investig. 2018;22(5):2021–9. https://doi.org/10.1007/s00784-017-2296-7.

    Article  PubMed  Google Scholar 

  32. Hegde S, Sowmya B, Mathew S, Bhandi SH, Nagaraja S, Dinesh K. Clinical evaluation of mineral trioxide aggregate and Biodentine as direct pulp capping agents in carious teeth. J Conserv Dent. 2017;20(2):91–5. https://doi.org/10.4103/0972-0707.212243.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Katge FA, Patil DP. Comparative analysis of 2 calcium silicate-based cements (Biodentine and mineral trioxide aggregate) as direct pulp-capping agent in young permanent molars: a Split mouth study. J Endod. 2017;43(4):507–13. https://doi.org/10.1016/j.joen.2016.11.026.

    Article  PubMed  Google Scholar 

  34. Linu S, Lekshmi MS, Varunkumar VS, Sam Joseph VG. Treatment outcome following direct pulp capping using bioceramic materials in mature permanent teeth with carious exposure: a pilot retrospective study. J Endod. 2017;43(10):1635–9. https://doi.org/10.1016/j.joen.2017.06.017.

    Article  PubMed  Google Scholar 

  35. Hashem D, Mannocci F, Patel S, Manoharan A, Brown JE, Watson TF, et al. Clinical and radiographic assessment of the efficacy of calcium silicate indirect pulp capping: a randomized controlled clinical trial. J Dent Res. 2015;94(4):562–8. https://doi.org/10.1177/0022034515571415.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Arshad E, Gyanendra K, Dhillon JK. Comparative evaluation of clinical outcome of indirect pulp treatment with calcium hydroxide, calcium silicate and Er,Cr:YSGG laser in permanent molars. Laser Ther. 2019;28(2):123–30. https://doi.org/10.5978/islsm.28_19-OR-09.

    Article  Google Scholar 

  37. Kusumvalli S, Diwan A, Pasha S, Devale MR, Chowdhary CD, Saikia P. Clinical evaluation of Biodentine: its efficacy in the management of deep dental caries. Indian J Dent Res. 2019;30(2):191–5. https://doi.org/10.4103/ijdr.IJDR_333_17.

    Article  PubMed  Google Scholar 

  38. Brizuela C, Ormeño A, Cabrera C, Cabezas R, Silva CI, Ramírez V, et al. Direct pulp capping with calcium hydroxide, mineral trioxide aggregate, and Biodentine in permanent young teeth with caries: a randomized clinical trial. J Endod. 2017;43(11):1776–80. https://doi.org/10.1016/j.joen.2017.06.031.

    Article  PubMed  Google Scholar 

  39. Parinyaprom N, Nirunsittirat A, Chuveera P, Na Lampang S, Srisuwan T, Sastraruji T, et al. Outcomes of direct pulp capping by using either ProRoot mineral trioxide aggregate or Biodentine in permanent teeth with carious pulp exposure in 6- to 18-year-old patients: a randomized controlled trial. J Endod. 2018;44(3):341–8. https://doi.org/10.1016/j.joen.2017.10.012.

    Article  PubMed  Google Scholar 

  40. Dube K, Jain P, Rai A, Paul B. Preventive endodontics by direct pulp capping with restorative dentin substitute-Biodentine: a series of fifteen cases. Indian J Dent Res. 2018;29(3):268–74. https://doi.org/10.4103/ijdr.IJDR_292_15.

    Article  PubMed  Google Scholar 

  41. Hashem DF, Foxton R, Manoharan A, Watson TF, Banerjee A. The physical characteristics of resin composite-calcium silicate interface as part of a layered/laminate adhesive restoration. Dent Mater. 2014;30(3):343–9. https://doi.org/10.1016/j.dental.2013.12.010.

    Article  PubMed  Google Scholar 

  42. Ricucci D, Siqueira JF Jr, Li Y, Tay FR. Vital pulp therapy: histopathology and histobacteriology-based guidelines to treat teeth with deep caries and pulp exposure. J Dent. 2019;86:41–52. https://doi.org/10.1016/j.jdent.2019.05.022.

    Article  PubMed  Google Scholar 

  43. Cushley S, Duncan HF, Lappin MJ, Chua P, Elamin AD, Clarke M, El-Karim IA. Efficacy of direct pulp capping for management of cariously exposed pulps in permanent teeth: a systematic review and meta-analysis. Int Endod J. 2020; https://doi.org/10.1111/iej.13449.

  44. Mente J, Hufnagel S, Leo M, Michel A, Gehrig H, Panagidis D, Saure D, Pfefferle T. Treatment outcome of mineral trioxide aggregate or calcium hydroxide direct pulp capping: long-term results. J Endod. 2014;40(11):1746–51. https://doi.org/10.1016/j.joen.2014.07.019.

    Article  PubMed  Google Scholar 

  45. Cho SY, Seo DG, Lee SJ, Lee J, Lee SJ, Jung IY. Prognostic factors for clinical outcomes according to time after direct pulp capping. J Endod. 2013;39(3):327–31. https://doi.org/10.1016/j.joen.2012.11.034.

    Article  PubMed  Google Scholar 

  46. Matsuo T, Nakanishi T, Shimizu H, Ebisu S. A clinical study of direct pulp capping applied to carious-exposed pulps. J Endod. 1996;22(10):551–6. https://doi.org/10.1016/S0099-2399(96)80017-3.

    Article  PubMed  Google Scholar 

  47. Fuks AB, Heling I, Nuni E. Pulp therapy for the young permanent dentition. In: Casamassimo PS, Fields HW, McTigue DJ, Nowak AJ, editors. Pediatric dentistry: infancy through adolescence. 5th ed. St. Louis: Saunders; 2013.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Athina Bakopoulou .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Bakopoulou, A., Koutrouli, A., About, I. (2022). Calcium Silicate-Based Cement (Biodentine™) as a Bioactive Material for the Long-Term Preservation of Pulp Vitality in Restorative Dentistry and Prosthodontics. In: About, I. (eds) Biodentine™. Springer, Cham. https://doi.org/10.1007/978-3-030-80932-4_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-80932-4_9

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-80931-7

  • Online ISBN: 978-3-030-80932-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics